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> Protein (NX_Q5VWQ8)
Protein (NX_Q5VWQ8)
Protein
Gene SymbolDAB2IP to neXtProt (NX_Q5VWQ8)
DescriptionDisabled homolog 2-interacting protein
Chromosome9
Location9q33.2 (124329336 ~ 124547809) to Ensembl
Sequene Features : Isoforms 5, Variants 117, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of apoptotic signaling pathway
.positive regulation of neuron migration
.negative regulation of cyclin catabolic process
  + 69 more...
.14-3-3 protein binding
.phosphatidylinositol-4-phosphate binding
.protein phosphatase 2A binding
  + 15 more...
.AIP1-IRE1 complex
.parallel fiber
.extracellular exosome
  + 10 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 117 10
2014-09-19protein level
5 86 10
2014-05-27protein level
5 86 12
2014-02-25protein level
5 85 12
2013-12-09protein level
5 63 12
2013-11-01protein level
5 57 12
2013-09-12protein level
5 57 12
2013-08-17protein level
5 57 12
2013-07-15protein level
4 41 12
2013-06-11protein level
4 41 12
2013-02-12protein level
4 24 24
2012-12-20protein level
4 24 24
2012-10-30protein level
4 31 24
2012-10-07protein level
4 31 7
2012-08-24protein level
4 29 7
2012-07-28protein level
4 29 7
2012-06-08protein level
4 36 7
2012-05-07protein level
4 28 7
2012-04-10protein level
4 28 7
2012-01-13protein level
4 15 7
2011-12-20protein level
4 15 7
2011-11-11protein level
4 15 6
2011-08-23protein level
4 15 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q5VWQ8-1
2 49 6 131542.7683
NX_Q5VWQ8-2
0 46 6 117577.3787
NX_Q5VWQ8-3
0 45 4 106697.1569
NX_Q5VWQ8-4
0 46 4 114337.8139
NX_Q5VWQ8-5
1 49 4 124962.171
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-9543020,EBI-710484 AXIN1  
  .positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.positive regulation of canonical Wnt signaling pathway
.Wnt signaling pathway involved in somitogenesis
  + 45 more...
.I-SMAD binding
.armadillo repeat domain binding
.SMAD binding
  + 9 more...
.cell periphery
.perinuclear region of cytoplasm
.cytoplasmic vesicle
  + 10 more...
2 EBI-9543020,EBI-373586 GSK3B  
  .positive regulation of stem cell differentiation
.negative regulation of glycogen (starch) synthase activity
.negative regulation of type B pancreatic cell development
  + 61 more...
.NF-kappaB binding
.tau-protein kinase activity
.protein kinase A catalytic subunit binding
  + 8 more...
.perinuclear region of cytoplasm
.membrane raft
.dendritic shaft
  + 11 more...
3 EBI-2871881,EBI-476263 MAP3K5  
  .cellular response to reactive nitrogen species
.positive regulation of neuron death
.programmed necrotic cell death
  + 18 more...
.protein homodimerization activity
.protein phosphatase binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
  + 4 more...
.IRE1-TRAF2-ASK1 complex
.protein kinase complex
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
bone97
brain52
cervix41
connective tissue33
embryonic tissue70
eye105
intestine43
kidney47
larynx85
liver4
lung59
mammary gland52
muscle9
nerve128
ovary157
pancreas18
parathyroid97
placenta49
prostate26
skin42
stomach20
testis22
thymus12
thyroid150
uterus90
vascular38
Health State
TissuesTPM*
normal55
breast (mammary gland) tumor32
cervical tumor57
chondrosarcoma156
colorectal tumor62
germ cell tumor45
glioma121
head and neck tumor37
kidney tumor14
lung tumor77
non-neoplasia51
ovarian tumor144
pancreatic tumor28
primitive neuroectodermal tumor of the CNS15
prostate cancer28
retinoblastoma86
skin tumor63
soft tissue/muscle tissue tumor15
uterine tumor122
Developmental Stage
TissuesTPM*
adult56
embryoid body114
blastocyst97
fetus46
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16.2
adrenal gland10.2
appendix8.8
cerebral cortex16.7
colon21.8
duodenum13.4
esophagus17
gallbladder13.3
heart muscle18
kidney18.7
liver2.9
lung19.5
lymph node3.7
ovary13.8
pancreas5.8
placenta13.4
prostate15.3
salivary gland26.3
skin9.8
small intestine16.1
spleen14.9
stomach15.2
testis23.4
thyroid gland11.6
urinary bladder18.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609205, gene) Dab2-interacting protein; DAB2IPOMIM


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