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> Protein (NX_Q5VWX1)
Protein (NX_Q5VWX1)
Protein
Gene SymbolKHDRBS2 to neXtProt (NX_Q5VWX1)
DescriptionKH domain-containing, RNA-binding, signal transduction-associated protein 2
Chromosome6
Location6q11.1 (62389865 ~ 62996132) to Ensembl
Sequene Features : Isoforms 1, Variants 129, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(U) RNA binding
.poly(A) binding
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 129 0
2014-09-19protein level
1 86 0
2014-05-27protein level
1 86 2
2014-02-25protein level
1 84 2
2013-12-09protein level
1 71 2
2013-11-01protein level
1 68 1
2013-09-12protein level
1 68 1
2013-08-17protein level
1 68 1
2013-07-15protein level
1 48 0
2013-06-11protein level
1 48 0
2013-02-12protein level
1 27 1
2012-12-20protein level
1 27 1
2012-10-30protein level
1 30 1
2012-10-07protein level
1 30 1
2012-08-24protein level
1 12 1
2012-07-28protein level
1 12 1
2012-06-08protein level
1 15 1
2012-05-07protein level
1 15 1
2012-04-10protein level
1 15 1
2012-01-13protein level
1 13 1
2011-12-20protein level
1 13 1
2011-11-11protein level
1 13 1
2011-08-23protein level
1 13 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q5VWX1-1
12 0 2 38903.4163
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-742808,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-742808,EBI-713419 HNRNPR  
  .gene expression
.RNA splicing
.mRNA processing
.mRNA splicing, via spliceosome
.poly(A) RNA binding
.RNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.ribonucleoprotein complex
.cytoplasm
  + 2 more...
3 EBI-742808,EBI-719843 HBZ  
  .erythrocyte maturation
.negative regulation of transcription from RNA polymerase II promoter
.heme binding
.oxygen binding
.iron ion binding
.oxygen transporter activity
.extracellular exosome
.hemoglobin complex
4 EBI-742808,EBI-10196922 SULT1A3  
  .sulfation
.3'-phosphoadenosine 5'-phosphosulfate metabolic process
.small molecule metabolic process
  + 7 more...
.sulfotransferase activity
.aryl sulfotransferase activity
.cytosol
5 EBI-742808,EBI-1383454 TYK2  
  .regulation of type I interferon-mediated signaling pathway
.type I interferon signaling pathway
.innate immune response
  + 8 more...
.ATP binding
.growth hormone receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.cytoskeleton
  + 3 more...
6 EBI-742808,EBI-743526 RBMX  
  .cellular response to interleukin-1
.protein homooligomerization
.positive regulation of mRNA splicing, via spliceosome
  + 10 more...
.poly(A) RNA binding
.mRNA binding
.single-stranded RNA binding
  + 4 more...
.catalytic step 2 spliceosome
.extracellular exosome
.supraspliceosomal complex
  + 6 more...
7 EBI-742808,EBI-2803328 PRR3  
  .N/A .metal ion binding
.poly(A) RNA binding
.N/A
8 EBI-742808,EBI-2949699 RBM3  
  .positive regulation of translation
.production of miRNAs involved in gene silencing by miRNA
.response to cold
  + 3 more...
.poly(A) RNA binding
.ribosomal large subunit binding
.RNA binding
.nucleotide binding
.dendrite
.cytoplasm
.nucleus
9 EBI-742808,EBI-714236 MTA1  
  .negative regulation of nucleic acid-templated transcription
.positive regulation of protein autoubiquitination
.regulation of inflammatory response
  + 11 more...
.zinc ion binding
.transcription corepressor activity
.transcription coactivator activity
  + 5 more...
.intracellular membrane-bounded organelle
.NuRD complex
.microtubule
  + 4 more...
10 EBI-742808,EBI-1383632 PTK6  
  .cellular response to retinoic acid
.negative regulation of protein tyrosine kinase activity
.intestinal epithelial cell differentiation
  + 12 more...
.identical protein binding
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasm
.nucleoplasm
  + 2 more...
11 EBI-742808,EBI-538850 CIRBP  
  .mRNA stabilization
.positive regulation of translation
.stress granule assembly
  + 3 more...
.small ribosomal subunit rRNA binding
.poly(A) RNA binding
.translation repressor activity
  + 2 more...
.cytoplasmic stress granule
.cytoplasm
.nucleoplasm
.nucleus
12 EBI-742808,EBI-744545 CATSPER1  
  .membrane depolarization during action potential
.calcium ion import
.regulation of cilium beat frequency involved in ciliary motility
  + 9 more...
.voltage-gated calcium channel activity
.calcium activated cation channel activity
.CatSper complex
.motile cilium
.plasma membrane
13 EBI-742808,EBI-742060 TYMSOS  
  .N/A .N/A .N/A
14 EBI-742808,EBI-8637627 AEN  
  .nucleic acid phosphodiester bond hydrolysis
.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.response to ionizing radiation
.exonuclease activity
.nucleic acid binding
.nuclear membrane
.nucleolus
.nucleoplasm
.nucleus
15 EBI-742808,EBI-448771 DOCK2  
  .positive regulation of phagocytosis
.regulation of defense response to virus by virus
.alpha-beta T cell proliferation
  + 12 more...
.T cell receptor binding
.Rac guanyl-nucleotide exchange factor activity
.extracellular exosome
.membrane
.endomembrane system
  + 2 more...
16 EBI-742808,EBI-2889252 NABP1  
  .response to ionizing radiation
.mitotic cell cycle checkpoint
.cellular response to DNA damage stimulus
  + 2 more...
.RNA binding
.single-stranded DNA binding
.SOSS complex
.cytoplasm
.nucleoplasm
.nucleus
17 EBI-742808,EBI-2849854 YTHDC1  
  .mRNA splice site selection .N6-methyladenosine-containing RNA binding
.poly(A) RNA binding
.RNA binding
.nuclear body
.nucleus
18 EBI-742808,EBI-748927 NPDC1  
  .N/A .N/A .integral component of membrane
19 EBI-742808,EBI-717201 SPG7  
  .anterograde axon cargo transport
.nervous system development
.mitochondrion organization
.proteolysis
.unfolded protein binding
.zinc ion binding
.peptidase activity
  + 2 more...
.mitochondrial membrane
.integral component of membrane
.mitochondrion
20 EBI-742808,EBI-347794 CHTOP  
  .positive regulation of helicase activity
.positive regulation of ATPase activity
.mRNA export from nucleus
  + 2 more...
.poly(A) RNA binding .intracellular membrane-bounded organelle
.nuclear speck
.nucleolus
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain11
embryonic tissue14
lung5
spleen18
testis4
Health State
TissuesTPM*
normal6
germ cell tumor11
Developmental Stage
TissuesTPM*
adult3
embryoid body28
fetus5
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland1.3
cerebral cortex5.1
lung4.8
spleen1.4
thyroid gland4.5
Tissues
TissuesExpression level
adrenal glandLow
appendixLow
breastLow
bronchusLow
cerebellumHigh
cerebral cortexHigh
colonHigh
duodenumLow
endometrium 2Low
epididymisHigh
gallbladderLow
hippocampusHigh
kidneyMedium
lateral ventricleHigh
lungLow
nasopharynxMedium
ovaryMedium
placentaMedium
rectumMedium
salivary glandLow
skin 1Low
small intestineMedium
soft tissue 2Medium
testisMedium
thyroid glandHigh
tonsilLow
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610487, gene) Kh domain-containing, rna-binding, signal transduction-associatedOMIM


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