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> Protein (NX_Q5W5X9)
Protein (NX_Q5W5X9)
Protein
Gene SymbolTTC23 to neXtProt (NX_Q5W5X9)
DescriptionTetratricopeptide repeat protein 23
Chromosome15
Location15q26.3 (99676528 ~ 99791428) to Ensembl
Sequene Features : Isoforms 3, Variants 57, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01transcript level
3 57 0
2014-09-19transcript level
3 47 0
2014-05-27transcript level
3 47 0
2014-02-25transcript level
3 47 0
2013-12-09transcript level
3 33 0
2013-11-01transcript level
3 31 0
2013-09-12transcript level
3 31 0
2013-08-17transcript level
3 31 0
2013-07-15transcript level
3 18 0
2013-06-11transcript level
3 18 0
2013-02-12transcript level
3 11 0
2012-12-20transcript level
3 8 0
2012-10-30transcript level
3 13 0
2012-10-07transcript level
3 13 0
2012-08-24transcript level
3 11 0
2012-07-28transcript level
3 11 0
2012-06-08transcript level
3 12 0
2012-05-07transcript level
3 12 0
2012-04-10transcript level
3 12 0
2012-01-13transcript level
3 6 0
2011-12-20transcript level
3 6 0
2011-11-11transcript level
3 6 0
2011-08-23transcript level
3 6 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q5W5X9-1
4 18 0 49977.7043
NX_Q5W5X9-2
0 18 0 44146.7106
NX_Q5W5X9-3
1 18 0 44210.6944
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-6447954,EBI-711810 BHLHE40  
  .negative regulation of transcription, DNA-templated
.negative regulation of sequence-specific DNA binding transcription factor activity
.entrainment of circadian clock by photoperiod
  + 4 more...
.E-box binding
.protein heterodimerization activity
.MRF binding
  + 10 more...
.Golgi apparatus
.nucleolus
.nucleoplasm
.nucleus
2 EBI-6447954,EBI-742268 TADA2A  
  .histone H3 acetylation
.transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.chromatin organization
.zinc ion binding
.transcription cofactor activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.chromosome
.nucleus
.PCAF complex
3 EBI-6447954,EBI-748961 CCNDBP1  
  .regulation of cell cycle
.cell cycle
.N/A .cytoplasm
.nucleoplasm
.nucleus
4 EBI-6447954,EBI-740738 LDOC1  
  .negative regulation of cell proliferation .N/A .nucleolus
.nucleus
5 EBI-6447954,EBI-3905054 ALAS1  
  .small molecule metabolic process
.cellular lipid metabolic process
.mitochondrion organization
  + 4 more...
.pyridoxal phosphate binding
.5-aminolevulinate synthase activity
.mitochondrial matrix
.mitochondrion
.cytoplasm
.nucleoplasm
6 EBI-6447954,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
7 EBI-6447954,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
8 EBI-6447954,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
9 EBI-6447954,EBI-947360 CNTROB  
  .mitotic cytokinetic process
.centrosome separation
.centriole replication
.protein domain specific binding .centriole
.centrosome
.cytoplasm
10 EBI-6447954,EBI-10171633 PNMA5  
  .positive regulation of apoptotic process .identical protein binding .N/A
11 EBI-6447954,EBI-413317 SPAG5  
  .regulation of attachment of spindle microtubules to kinetochore
.cell division
.chromosome segregation
  + 2 more...
.N/A .mitotic spindle
.microtubule plus-end
.midbody
  + 7 more...
12 EBI-6447954,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
13 EBI-6447954,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
14 EBI-6447954,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
15 EBI-6447954,EBI-632965 CREBZF  
  .regulation of sequence-specific DNA binding transcription factor activity
.negative regulation of transcription, DNA-templated
.negative regulation of gene expression, epigenetic
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
16 EBI-6447954,EBI-6427325 TRIM10  
  .negative regulation of viral entry into host cell
.innate immune response
.erythrocyte differentiation
.zinc ion binding .cytoplasm
17 EBI-6447954,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
18 EBI-6447954,EBI-716006 MAGED1  
  .positive regulation of apoptotic signaling pathway
.extrinsic apoptotic signaling pathway in absence of ligand
.extrinsic apoptotic signaling pathway
  + 15 more...
.transcription coactivator activity .protein complex
.plasma membrane
.cytoplasm
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites50
bladder66
blood16
bone13
brain25
connective tissue53
embryonic tissue18
esophagus49
testis2
Health State
TissuesTPM*
bladder carcinoma56
breast (mammary gland) tumor21
chondrosarcoma36
colorectal tumor26
esophageal tumor57
Developmental Stage
TissuesTPM*
adult23
embryoid body14
blastocyst16
neonate64
fetus10
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.5
adrenal gland13
appendix5.8
cerebral cortex4.7
colon10.3
duodenum6
esophagus13.1
gallbladder12.9
heart muscle7.3
kidney9.8
liver6.2
lung8.7
lymph node4.6
ovary18.4
pancreas4.6
placenta10.3
prostate9.9
salivary gland4.9
skin11.1
small intestine6.2
spleen6.8
stomach7
testis16.7
thyroid gland16
urinary bladder11.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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