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> Protein (NX_Q63HR2)
Protein (NX_Q63HR2)
Protein
Gene SymbolTENC1 to neXtProt (NX_Q63HR2)
DescriptionTensin-like C1 domain-containing phosphatase
Chromosome12
Location12q13.13 (53440753 ~ 53458156) to Ensembl
Sequene Features : Isoforms 5, Variants 153, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.multicellular organismal homeostasis
.intracellular signal transduction
.multicellular organism growth
  + 5 more...
.metal ion binding
.kinase binding
.phosphoprotein phosphatase activity
.focal adhesion
.plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 153 9
2014-09-19protein level
5 121 9
2014-05-27protein level
5 121 9
2014-02-25protein level
5 120 9
2013-12-09protein level
5 69 9
2013-11-01protein level
5 67 9
2013-09-12protein level
5 67 13
2013-08-17protein level
5 67 13
2013-07-15protein level
5 50 13
2013-06-11protein level
5 50 13
2013-02-12protein level
5 27 43
2012-12-20protein level
5 29 43
2012-10-30protein level
5 36 43
2012-10-07protein level
5 36 9
2012-08-24protein level
5 36 9
2012-07-28protein level
5 35 9
2012-06-08protein level
5 45 9
2012-05-07protein level
5 42 9
2012-04-10protein level
5 42 9
2012-01-13protein level
5 23 9
2011-12-20protein level
5 23 9
2011-11-11protein level
5 23 9
2011-08-23protein level
5 22 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q63HR2-1
0 65 1 152484.1298
NX_Q63HR2-2
1 58 1 142594.4111
NX_Q63HR2-4
2 65 1 153466.5888
NX_Q63HR2-5
0 60 1 138740.7828
NX_Q63HR2-6
1 64 1 152356.0716
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-949753,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
2 EBI-949753,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
3 EBI-949753,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
4 EBI-949753,EBI-10177272 ZNF250  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
5 EBI-949753,EBI-720706 ERBB3  
  .extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein tyrosine kinase activity
.neuron apoptotic process
  + 21 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
  + 5 more...
.receptor complex
.lateral plasma membrane
.apical plasma membrane
  + 4 more...
6 EBI-949753,EBI-10176379 KRTAP12-2  
  .N/A .N/A .keratin filament
7 EBI-949753,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
8 EBI-949753,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
9 EBI-949753,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
10 EBI-949753,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
11 EBI-949753,EBI-2513407 PKP1  
  .intermediate filament bundle assembly
.single organismal cell-cell adhesion
.programmed cell death
  + 5 more...
.structural constituent of epidermis
.intermediate filament binding
.lamin binding
.signal transducer activity
.extracellular exosome
.intracellular membrane-bounded organelle
.desmosome
  + 4 more...
12 EBI-949753,EBI-6660291 C11orf87  
  .N/A .N/A .integral component of membrane
13 EBI-949753,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
14 EBI-949753,EBI-750345 REEP6  
  .regulation of intracellular transport .N/A .apical part of cell
.rod spherule
.integral component of membrane
  + 2 more...
15 EBI-949753,EBI-10239812 TEKT5  
  .N/A .N/A .cilium
.microtubule
.cytoplasm
.nucleus
16 EBI-949753,EBI-6427977 ZNF587  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
17 EBI-949753,EBI-10313866 C19orf66  
  .N/A .N/A .N/A
18 EBI-949753,EBI-1048886 NUBP2  
  .small molecule metabolic process
.iron-sulfur cluster assembly
.4 iron, 4 sulfur cluster binding
.metal ion binding
.ATP binding
.nucleotide binding
.spindle pole centrosome
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites25
bone125
brain41
connective tissue53
embryonic tissue14
eye81
heart11
intestine51
kidney109
liver19
lung77
lymph node11
mammary gland79
muscle28
nerve321
ovary29
pancreas89
parathyroid48
pharynx49
placenta35
prostate36
salivary gland49
skin52
spleen112
stomach31
testis6
thymus12
thyroid214
trachea19
uterus38
vascular19
Health State
TissuesTPM*
normal52
adrenal tumor158
bladder carcinoma56
breast (mammary gland) tumor139
cervical tumor28
chondrosarcoma72
colorectal tumor62
gastrointestinal tumor33
germ cell tumor49
glioma102
head and neck tumor52
kidney tumor72
liver tumor31
lung tumor77
lymphoma13
non-neoplasia41
ovarian tumor39
pancreatic tumor76
primitive neuroectodermal tumor of the CNS15
skin tumor63
soft tissue/muscle tissue tumor31
uterine tumor88
Developmental Stage
TissuesTPM*
adult52
embryoid body42
fetus98
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue147.9
adrenal gland64.7
appendix22
cerebral cortex21.3
colon23.1
duodenum20.6
esophagus29.6
gallbladder47.4
heart muscle54.3
kidney42.9
liver23.7
lung60.5
lymph node20.9
ovary80.7
pancreas20.4
placenta35.1
prostate48.6
salivary gland36.5
skin17.2
small intestine26
spleen71.8
stomach22.8
testis20.9
thyroid gland38.6
urinary bladder35.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607717, gene) Tensin-like c1 domain-containing phosphatase; TENC1OMIM


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