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> Protein (NX_Q66PJ3)
Protein (NX_Q66PJ3)
Protein
Gene SymbolARL6IP4 to neXtProt (NX_Q66PJ3)
DescriptionADP-ribosylation factor-like protein 6-interacting protein 4
Chromosome12
Location12q24.31 (123464607 ~ 123467456) to Ensembl
Sequene Features : Isoforms 7, Variants 50, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.RNA splicing
.mRNA processing
.poly(A) RNA binding .nuclear speck
.nucleolus
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
7 50 9
2014-09-19protein level
7 41 9
2014-05-27protein level
7 39 9
2014-02-25protein level
6 39 9
2013-12-09protein level
6 19 9
2013-11-01protein level
6 18 9
2013-09-12protein level
6 18 9
2013-08-17protein level
6 18 9
2013-07-15protein level
6 12 5
2013-06-11protein level
6 12 5
2013-02-12protein level
6 10 12
2012-12-20protein level
6 14 12
2012-10-30protein level
6 15 12
2012-10-07protein level
6 15 4
2012-08-24protein level
6 15 4
2012-07-28protein level
6 15 4
2012-06-08protein level
6 17 4
2012-05-07protein level
6 17 4
2012-04-10protein level
6 17 4
2012-01-13protein level
6 9 4
2011-12-20protein level
6 9 4
2011-11-11protein level
6 9 4
2011-08-23protein level
6 9 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q66PJ3-1
1 18 0 44888.0676
NX_Q66PJ3-2
0 19 0 44131.722
NX_Q66PJ3-3
0 18 0 43106.1997
NX_Q66PJ3-4
1 17 0 42705.1253
NX_Q66PJ3-5
1 16 0 38675.1219
NX_Q66PJ3-6
1 11 0 28510.7795
NX_Q66PJ3-7
1 7 0 25333.2102
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-5280499,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
2 EBI-10248982,EBI-1051785 SRSF11  
  .mRNA 3'-end processing
.gene expression
.RNA splicing
  + 5 more...
.poly(A) RNA binding
.nucleotide binding
.nucleoplasm
.nucleus
3 EBI-10248982,EBI-395290 RBM39  
  .RNA splicing
.mRNA processing
.RNA processing
  + 2 more...
.poly(A) RNA binding
.nucleotide binding
.nuclear speck
.microtubule cytoskeleton
.microtubule organizing center
.nucleoplasm
4 EBI-5280499,EBI-79893 PIK3R3  
  .phosphatidylinositol phosphorylation
.small molecule metabolic process
.regulation of phosphatidylinositol 3-kinase activity
  + 4 more...
.1-phosphatidylinositol-3-kinase regulator activity
.1-phosphatidylinositol-3-kinase activity
.phosphatidylinositol 3-kinase complex
.cytosol
5 EBI-10248982,EBI-2130266 RNF41  
  .positive regulation of reactive oxygen species metabolic process
.regulation of reactive oxygen species metabolic process
.regulation of establishment of cell polarity
  + 12 more...
.ubiquitin protein ligase activity
.protein tag
.Ral GTPase binding
  + 3 more...
.cytosol
6 EBI-10248982,EBI-741515 THAP1  
  .regulation of mitotic cell cycle
.cell cycle
.regulation of transcription, DNA-templated
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.zinc ion binding
.PML body
.nucleus
7 EBI-2683099,EBI-81279 IKBKG  
  .negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.negative regulation of neuron death
.nucleotide-binding oligomerization domain containing signaling pathway
  + 35 more...
.linear polyubiquitin binding
.K63-linked polyubiquitin binding
.protein heterodimerization activity
  + 5 more...
.mitotic spindle
.IkappaB kinase complex
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland121
ascites100
bladder33
blood32
bone209
brain53
cervix123
connective tissue33
embryonic tissue93
esophagus49
eye143
heart11
intestine107
kidney28
liver82
lung98
lymph135
lymph node33
mammary gland46
mouth136
muscle122
ovary68
pancreas168
pituitary gland242
placenta38
prostate68
salivary gland148
skin94
spleen74
stomach41
testis36
thymus25
umbilical cord145
uterus77
Health State
TissuesTPM*
normal54
adrenal tumor237
breast (mammary gland) tumor75
cervical tumor173
chondrosarcoma169
colorectal tumor151
esophageal tumor57
gastrointestinal tumor75
germ cell tumor22
glioma130
head and neck tumor97
kidney tumor29
leukemia42
liver tumor72
lung tumor126
lymphoma152
non-neoplasia31
ovarian tumor26
pancreatic tumor228
primitive neuroectodermal tumor of the CNS86
prostate cancer77
retinoblastoma86
skin tumor135
soft tissue/muscle tissue tumor95
uterine tumor110
Developmental Stage
TissuesTPM*
adult77
embryoid body128
blastocyst113
neonate64
fetus41
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue92.5
adrenal gland127
appendix82.9
bone marrow100.5
cerebral cortex59.2
colon82.9
duodenum105.1
esophagus80.6
gallbladder85.5
heart muscle114
kidney124.4
liver80.3
lung84.8
lymph node114.1
ovary106.3
pancreas77
placenta70
prostate98.1
salivary gland120.3
skin72.6
small intestine97.2
spleen109.1
stomach85.1
testis68
thyroid gland92.9
urinary bladder87.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607668, gene) Adp-ribosylation-like factor 6-interacting protein 4; ARL6IP4OMIM


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