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> Protein (NX_Q68CZ2)
Protein (NX_Q68CZ2)
Protein
Gene SymbolTNS3 to neXtProt (NX_Q68CZ2)
DescriptionTensin-3
Chromosome7
Location7p12.3 (47314752 ~ 47622156) to Ensembl
Sequene Features : Isoforms 4, Variants 194, PTMs 26 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.lung alveolus development
.cell migration
.positive regulation of cell proliferation
.N/A .focal adhesion
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 194 26
2014-09-19protein level
4 146 26
2014-05-27protein level
4 146 26
2014-02-25protein level
4 146 26
2013-12-09protein level
4 102 26
2013-11-01protein level
4 102 26
2013-09-12protein level
4 102 27
2013-08-17protein level
4 102 27
2013-07-15protein level
4 66 27
2013-06-11protein level
4 66 27
2013-02-12protein level
4 33 50
2012-12-20protein level
4 29 50
2012-10-30protein level
4 48 50
2012-10-07protein level
4 48 25
2012-08-24protein level
4 37 25
2012-07-28protein level
4 37 25
2012-06-08protein level
4 8 25
2012-05-07protein level
4 8 25
2012-04-10protein level
4 8 25
2012-01-13protein level
4 8 25
2011-12-20protein level
4 8 25
2011-11-11protein level
4 8 19
2011-08-23protein level
4 8 19
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q68CZ2-1
4 48 2 155168.2083
NX_Q68CZ2-2
1 43 2 128984.3722
NX_Q68CZ2-3
1 16 0 43520.867
NX_Q68CZ2-4
1 11 0 28024.1051
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1220488,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
2 EBI-1220488,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
3 EBI-1220488,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
4 EBI-1220488,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
5 EBI-1220488,EBI-727477 CDH1  
  .regulation of neuron migration
.regulation of protein localization to cell surface
.cochlea development
  + 39 more...
.cell adhesion molecule binding
.gamma-catenin binding
.GTPase activating protein binding
  + 4 more...
.extracellular exosome
.perinuclear region of cytoplasm
.apical part of cell
  + 21 more...
6 EBI-1220488,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
7 EBI-1220488,EBI-720706 ERBB3  
  .extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein tyrosine kinase activity
.neuron apoptotic process
  + 21 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
  + 5 more...
.receptor complex
.lateral plasma membrane
.apical plasma membrane
  + 4 more...
8 EBI-1220488,EBI-702093 BCAR1  
  .cell chemotaxis
.cell division
.B cell receptor signaling pathway
  + 21 more...
.protein kinase binding
.signal transducer activity
.lamellipodium
.actin cytoskeleton
.focal adhesion
  + 5 more...
9 EBI-1220488,EBI-702142 PTK2  
  .negative regulation of anoikis
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of substrate adhesion-dependent cell spreading
  + 56 more...
.SH2 domain binding
.protein kinase binding
.JUN kinase binding
  + 7 more...
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
.apical plasma membrane
  + 9 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites25
bladder66
blood16
bone83
bone marrow20
brain32
connective tissue60
embryonic tissue75
eye90
heart44
intestine107
kidney85
larynx255
liver48
lung62
lymph45
lymph node77
mammary gland52
mouth60
muscle37
nerve128
ovary59
pancreas32
parathyroid48
placenta169
prostate5
salivary gland49
skin132
spleen93
stomach41
testis20
thyroid171
uterus99
vascular96
Health State
TissuesTPM*
normal72
breast (mammary gland) tumor21
chondrosarcoma84
colorectal tumor151
gastrointestinal tumor33
germ cell tumor22
glioma65
head and neck tumor89
kidney tumor116
leukemia10
liver tumor62
lung tumor38
lymphoma41
non-neoplasia144
ovarian tumor39
pancreatic tumor47
skin tumor135
soft tissue/muscle tissue tumor55
uterine tumor122
Developmental Stage
TissuesTPM*
adult90
embryoid body128
blastocyst97
neonate128
fetus87
infant170
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue25.3
adrenal gland20.6
appendix22.2
bone marrow3.6
cerebral cortex18.6
colon17.6
duodenum15.8
esophagus5.5
gallbladder23.2
heart muscle18.3
kidney38.5
liver18.2
lung41.6
lymph node34.9
ovary38.6
pancreas25.9
placenta52.1
prostate9.1
salivary gland33.4
skin9.3
small intestine17.2
spleen32.1
stomach22.7
testis11.6
thyroid gland29.9
urinary bladder21.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606825, gene) Tensin 3; TNS3OMIM


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