Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q6A162)
Protein (NX_Q6A162)
Protein
Gene SymbolKRT40 to neXtProt (NX_Q6A162)
DescriptionKeratin, type I cytoskeletal 40
Chromosome17
Location17q21.2 (39133968 ~ 39143387) to Ensembl
Sequene Features : Isoforms 1, Variants 70, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .structural molecule activity .intermediate filament
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 70 0
2014-09-19protein level
1 52 0
2014-05-27protein level
1 52 0
2014-02-25protein level
1 52 0
2013-12-09protein level
1 33 0
2013-11-01protein level
1 33 0
2013-09-12protein level
1 33 0
2013-08-17protein level
1 33 0
2013-07-15protein level
1 25 0
2013-06-11protein level
1 25 0
2013-02-12protein level
1 19 0
2012-12-20protein level
1 14 0
2012-10-30protein level
1 24 0
2012-10-07protein level
1 24 0
2012-08-24protein level
1 22 0
2012-07-28protein level
1 23 0
2012-06-08protein level
1 26 0
2012-05-07protein level
1 25 0
2012-04-10protein level
1 25 0
2012-01-13protein level
1 14 0
2011-12-20protein level
1 14 0
2011-11-11protein level
1 14 0
2011-08-23protein level
1 14 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q6A162-1
17 0 2 48107.4685
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10171697,EBI-10171684 C14orf182  
  .N/A .N/A .N/A
2 EBI-10171697,EBI-10173222 DCDC2B  
  .intracellular signal transduction .N/A .N/A
3 EBI-10171697,EBI-10173491 CLEC18A  
  .N/A .carbohydrate binding .extracellular region
4 EBI-10171697,EBI-10173955 C5orf60  
  .N/A .N/A .integral component of membrane
5 EBI-10171697,EBI-740220 HGS  
  .positive regulation of exosomal secretion
.protein localization to membrane
.membrane organization
  + 13 more...
.metal ion binding
.protein domain specific binding
.extracellular exosome
.intracellular membrane-bounded organelle
.multivesicular body membrane
  + 6 more...
6 EBI-10171697,EBI-744471 ZBTB24  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.hematopoietic progenitor cell differentiation
.metal ion binding
.DNA binding
.nucleus
7 EBI-10171697,EBI-8646694 DCX  
  .dendrite morphogenesis
.axon extension
.protein autophosphorylation
  + 8 more...
.protein kinase binding
.calcium-dependent protein serine/threonine kinase activity
.microtubule binding
  + 2 more...
.neuron projection
.microtubule associated complex
.microtubule
  + 4 more...
8 EBI-10171697,EBI-1053424 PRKAB2  
  .membrane organization
.regulation of protein kinase activity
.small molecule metabolic process
  + 13 more...
.identical protein binding .AMP-activated protein kinase complex
.cytosol
.nucleoplasm
9 EBI-10171697,EBI-947402 MAPKBP1  
  .N/A .N/A .N/A
10 EBI-10171697,EBI-398610 EIF4E2  
  .cytokine-mediated signaling pathway
.negative regulation of translation
.in utero embryonic development
.poly(A) RNA binding
.ubiquitin protein ligase binding
.translation factor activity, RNA binding
  + 2 more...
.mRNA cap binding complex
.cytosol
11 EBI-10171697,EBI-740402 DTNB  
  .N/A .zinc ion binding .synapse
.cytoplasm
12 EBI-10171697,EBI-718707 LRCH4  
  .nervous system development .N/A .PML body
13 EBI-10171697,EBI-743272 USP2  
  .regulation of proteasomal protein catabolic process
.protein stabilization
.positive regulation of skeletal muscle tissue development
  + 11 more...
.metal ion binding
.ubiquitin protein ligase binding
.cyclin binding
  + 2 more...
.perinuclear region of cytoplasm
.cell cortex
.centrosome
  + 2 more...
14 EBI-10171697,EBI-1050106 BCAS2  
  .gene expression
.RNA splicing
.mRNA splicing, via spliceosome
.RNA splicing, via transesterification reactions
.N/A .cell junction
.nucleolus
.spliceosomal complex
  + 2 more...
15 EBI-10171697,EBI-751960 ZNF202  
  .lipid metabolic process
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.mitochondrion
.nucleoplasm
.nucleus
16 EBI-10171697,EBI-2513774 FARS2  
  .gene expression
.tRNA processing
.phenylalanyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.phenylalanine-tRNA ligase activity
.magnesium ion binding
.tRNA binding
.mitochondrial matrix
.mitochondrion
17 EBI-10171697,EBI-750559 SLU7  
  .cellular response to heat
.intracellular protein transport
.mRNA splicing, via spliceosome
  + 3 more...
.pre-mRNA 3'-splice site binding
.zinc ion binding
.second spliceosomal transesterification activity
.catalytic step 2 spliceosome
.intracellular membrane-bounded organelle
.small nuclear ribonucleoprotein complex
  + 6 more...
18 EBI-10171697,EBI-743231 ASMTL  
  .N/A .O-methyltransferase activity .cytoplasm
19 EBI-10171697,EBI-1045459 SNAI1  
  .regulation of tight junction assembly
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.Notch signaling involved in heart development
  + 16 more...
.metal ion binding
.kinase binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.cytoplasm
.nucleus
20 EBI-10171697,EBI-10192902 FAM107A  
  .regulation of cell growth .N/A .neuron projection
.nucleus
21 EBI-10171697,EBI-1757866 MOS  
  .negative regulation of metaphase/anaphase transition of meiotic cell cycle
.establishment of meiotic spindle orientation
.protein autophosphorylation
  + 6 more...
.ATP binding
.MAP kinase kinase kinase activity
.protein serine/threonine kinase activity
.cytoplasm
22 EBI-10171697,EBI-719843 HBZ  
  .erythrocyte maturation
.negative regulation of transcription from RNA polymerase II promoter
.heme binding
.oxygen binding
.iron ion binding
.oxygen transporter activity
.extracellular exosome
.hemoglobin complex
23 EBI-10171697,EBI-702198 KRT6A  
  .activation of mitophagy in response to mitochondrial depolarization
.wound healing
.cell differentiation
  + 3 more...
.structural constituent of cytoskeleton .extracellular exosome
.keratin filament
.membrane
.nucleus
24 EBI-10171697,EBI-353997 GNAI2  
  .regulation of calcium ion transport
.cell division
.negative regulation of synaptic transmission
  + 17 more...
.metal ion binding
.G-protein beta/gamma-subunit complex binding
.GTP binding
  + 3 more...
.extracellular exosome
.membrane raft
.vesicle
  + 8 more...
25 EBI-10171697,EBI-297852 KRT8  
  .hepatocyte apoptotic process
.extrinsic apoptotic signaling pathway
.cell differentiation involved in embryonic placenta development
  + 5 more...
.scaffold protein binding
.structural molecule activity
.extracellular exosome
.intermediate filament cytoskeleton
.keratin filament
  + 10 more...
26 EBI-10171697,EBI-346340 HCK  
  .positive regulation of actin cytoskeleton reorganization
.regulation of podosome assembly
.cellular response to peptide hormone stimulus
  + 28 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.cell projection
.extrinsic component of cytoplasmic side of plasma membrane
.transport vesicle
  + 7 more...
27 EBI-10171697,EBI-352528 HSPD1  
  .protein maturation
.chaperone-mediated protein complex assembly
.positive regulation of T cell activation
  + 21 more...
.chaperone binding
.unfolded protein binding
.poly(A) RNA binding
  + 8 more...
.extracellular exosome
.lipopolysaccharide receptor complex
.protein complex
  + 13 more...
28 EBI-10171697,EBI-702187 KRT5  
  .cell junction assembly
.hemidesmosome assembly
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.keratin filament
.membrane
  + 6 more...
29 EBI-10171697,EBI-726527 TNNT1  
  .negative regulation of muscle contraction
.slow-twitch skeletal muscle fiber contraction
.muscle filament sliding
.skeletal muscle contraction
.tropomyosin binding .troponin complex
.cytosol
30 EBI-10171697,EBI-372475 SNRPB  
  .activation of mitophagy in response to mitochondrial depolarization
.ncRNA metabolic process
.mRNA 3'-end processing
  + 9 more...
.histone pre-mRNA DCP binding
.poly(A) RNA binding
.histone pre-mRNA 3'end processing complex
.catalytic step 2 spliceosome
.U2-type prespliceosome
  + 14 more...
31 EBI-10171697,EBI-10177272 ZNF250  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
32 EBI-10171697,EBI-747044 NPPB  
  .regulation of blood vessel size
.regulation of vascular permeability
.regulation of vasodilation
  + 9 more...
.diuretic hormone activity
.hormone activity
.receptor binding
.protein complex
.extracellular space
.extracellular region
33 EBI-10171697,EBI-717634 ZNF20  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
34 EBI-10171697,EBI-2841331 ZNF26  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
35 EBI-10171697,EBI-2371606 KRT4  
  .negative regulation of epithelial cell proliferation
.epithelial cell differentiation
.cytoskeleton organization
.structural molecule activity .intermediate filament cytoskeleton
.keratin filament
.cell surface
  + 2 more...
36 EBI-10171697,EBI-2320534 WT1  
  .positive regulation of metanephric ureteric bud development
.negative regulation of female gonad development
.positive regulation of male gonad development
  + 44 more...
.C2H2 zinc finger domain binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 4 more...
.nuclear speck
.cytoplasm
.nucleolus
  + 2 more...
37 EBI-10171697,EBI-3906571 CD33  
  .negative regulation of cell proliferation
.cell-cell signaling
.signal transduction
.cell adhesion
.carbohydrate binding
.receptor activity
.extracellular exosome
.external side of plasma membrane
.integral component of plasma membrane
.plasma membrane
38 EBI-10171697,EBI-715032 COX5A  
  .hydrogen ion transmembrane transport
.small molecule metabolic process
.cellular metabolic process
  + 3 more...
.metal ion binding
.electron carrier activity
.cytochrome-c oxidase activity
.extracellular exosome
.mitochondrial inner membrane
39 EBI-10171697,EBI-10200977 COMT  
  .regulation of sensory perception of pain
.positive regulation of homocysteine metabolic process
.negative regulation of smooth muscle cell proliferation
  + 20 more...
.catechol O-methyltransferase activity
.O-methyltransferase activity
.magnesium ion binding
.extracellular exosome
.postsynaptic membrane
.cell body
  + 7 more...
40 EBI-10171697,EBI-2806671 GATA2  
  .regulation of forebrain neuron differentiation
.negative regulation of neural precursor cell proliferation
.GABAergic neuron differentiation
  + 29 more...
.C2H2 zinc finger domain binding
.zinc ion binding
.transcription factor binding
  + 5 more...
.protein complex
.nucleoplasm
41 EBI-10171697,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
42 EBI-10171697,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
43 EBI-10171697,EBI-8639312 LMO1  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.zinc ion binding .nucleus
44 EBI-10171697,EBI-351257 DDX6  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.cytoplasmic mRNA processing body assembly
.viral RNA genome packaging
  + 4 more...
.poly(A) RNA binding
.protein domain specific binding
.ATP binding
  + 3 more...
.intracellular membrane-bounded organelle
.RISC complex
.membrane
  + 5 more...
45 EBI-10171697,EBI-1050897 CNTF  
  .ciliary neurotrophic factor-mediated signaling pathway
.neuron development
.muscle organ morphogenesis
  + 7 more...
.growth factor activity
.interleukin-6 receptor binding
.ciliary neurotrophic factor receptor binding
.cytoplasm
.extracellular space
46 EBI-10171697,EBI-747133 COL8A1  
  .epithelial cell proliferation
.camera-type eye morphogenesis
.endodermal cell differentiation
  + 6 more...
.N/A .extracellular exosome
.intracellular membrane-bounded organelle
.endoplasmic reticulum lumen
  + 2 more...
47 EBI-10171697,EBI-1383454 TYK2  
  .regulation of type I interferon-mediated signaling pathway
.type I interferon signaling pathway
.innate immune response
  + 8 more...
.ATP binding
.growth hormone receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.cytoskeleton
  + 3 more...
48 EBI-10171697,EBI-745213 AQP1  
  .cation transmembrane transport
.maintenance of symbiont-containing vacuole by host
.ammonium transmembrane transport
  + 60 more...
.carbon dioxide transmembrane transporter activity
.nitric oxide transmembrane transporter activity
.transmembrane transporter activity
  + 8 more...
.extracellular exosome
.apical part of cell
.axon terminus
  + 12 more...
49 EBI-10171697,EBI-2256865 TIE1  
  .plasma membrane fusion
.response to retinoic acid
.negative regulation of cell migration
  + 7 more...
.ATP binding
.transmembrane receptor protein tyrosine kinase activity
.integral component of plasma membrane
50 EBI-10171697,EBI-742094 KRT20  
  .regulation of protein secretion
.intermediate filament organization
.cellular response to stress
.apoptotic process
.structural constituent of cytoskeleton .intermediate filament
.cytoplasm
51 EBI-10171697,EBI-1247312 KRT2  
  .keratinocyte migration
.keratinocyte proliferation
.keratinocyte activation
  + 2 more...
.structural constituent of cytoskeleton .extracellular exosome
.intermediate filament cytoskeleton
.keratin filament
  + 6 more...
52 EBI-10171697,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
53 EBI-10171697,EBI-2558314 ALDH3B1  
  .oxidation-reduction process
.aldehyde catabolic process
.cellular response to oxidative stress
  + 3 more...
.aldehyde dehydrogenase [NAD(P)+] activity
.3-chloroallyl aldehyde dehydrogenase activity
.extracellular exosome
.vesicle
.plasma membrane
  + 2 more...
54 EBI-10171697,EBI-495538 FASLG  
  .positive regulation of endothelial cell apoptotic process
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.necroptotic signaling pathway
  + 30 more...
.receptor binding .extracellular exosome
.cytoplasmic membrane-bounded vesicle lumen
.perinuclear region of cytoplasm
  + 8 more...
55 EBI-10171697,EBI-10210114 NPBWR2  
  .opioid receptor signaling pathway
.synaptic transmission
.neuropeptide signaling pathway
  + 2 more...
.neuropeptide binding
.neuropeptide receptor activity
.opioid receptor activity
.neuron projection
.integral component of membrane
.integral component of plasma membrane
.plasma membrane
56 EBI-10171697,EBI-2564105 KRT6C  
  .intermediate filament cytoskeleton organization .structural molecule activity .extracellular exosome
.keratin filament
.intermediate filament
57 EBI-10171697,EBI-740785 HOXA1  
  .cochlea morphogenesis
.cochlea development
.cellular response to retinoic acid
  + 24 more...
.sequence-specific DNA binding .nucleus
58 EBI-10171697,EBI-10211940 MXI1  
  .cytoplasmic sequestering of transcription factor
.negative regulation of cell proliferation
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.transcription corepressor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
59 EBI-10171697,EBI-3905829 CCNG1  
  .cell division
.negative regulation of apoptotic process
.cell growth
  + 6 more...
.N/A .perinuclear region of cytoplasm
.neuronal cell body
.dendrite
.nucleus
60 EBI-10171697,EBI-10213071 ZNF138  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
61 EBI-10171697,EBI-744104 GEM  
  .metaphase plate congression
.chromosome organization
.metabolic process
  + 5 more...
.GDP binding
.GTP binding
.GTPase activity
.magnesium ion binding
.mitotic spindle
.spindle midzone
.midbody
  + 2 more...
62 EBI-10171697,EBI-746103 AQP5  
  .transmembrane transport
.camera-type eye morphogenesis
.saliva secretion
  + 8 more...
.glycerol channel activity
.water channel activity
.extracellular exosome
.apical plasma membrane
.basal plasma membrane
  + 4 more...
63 EBI-10171697,EBI-1048159 MFAP1  
  .extracellular matrix organization .poly(A) RNA binding .extracellular region
.microfibril
64 EBI-10171697,EBI-308629 HDAC4  
  .histone H4 deacetylation
.histone H3 deacetylation
.response to interleukin-1
  + 29 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 12 more...
.actomyosin
.A band
.neuromuscular junction
  + 7 more...
65 EBI-10171697,EBI-724442 RWDD2B  
  .N/A .N/A .N/A
66 EBI-10171697,EBI-2105393 UBASH3A  
  .negative regulation of T cell receptor signaling pathway
.regulation of cytokine production
.N/A .extracellular exosome
.cytosol
.nucleus
67 EBI-10171697,EBI-2798728 LMO4  
  .regulation of cell activation
.thymus development
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.zinc ion binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
.enhancer sequence-specific DNA binding
.transcription factor complex
68 EBI-10171697,EBI-357745 PSMC5  
  .positive regulation of proteasomal protein catabolic process
.positive regulation of canonical Wnt signaling pathway
.positive regulation of inclusion body assembly
  + 30 more...
.proteasome-activating ATPase activity
.thyrotropin-releasing hormone receptor binding
.TBP-class protein binding
  + 4 more...
.blood microparticle
.extracellular exosome
.cytosolic proteasome complex
  + 11 more...
69 EBI-10171697,EBI-354380 RPL11  
  .cellular protein metabolic process
.ribosomal large subunit biogenesis
.protein localization to nucleus
  + 12 more...
.poly(A) RNA binding
.rRNA binding
.structural constituent of ribosome
.RNA binding
.extracellular exosome
.cytosolic large ribosomal subunit
.membrane
  + 3 more...
70 EBI-10171697,EBI-413628 RAC1  
  .positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
.ruffle assembly
  + 63 more...
.Rho GDP-dissociation inhibitor binding
.thioesterase binding
.enzyme binding
  + 2 more...
.extracellular exosome
.melanosome
.cytoplasmic ribonucleoprotein granule
  + 12 more...
71 EBI-10171697,EBI-10220734 GNG5  
  .cellular response to glucagon stimulus
.small molecule metabolic process
.synaptic transmission
  + 3 more...
.PDZ domain binding
.signal transducer activity
.GTPase activity
.extracellular exosome
.membrane
.plasma membrane
.heterotrimeric G-protein complex
72 EBI-10171697,EBI-6693977 FKBP1B  
  .cell communication by electrical coupling involved in cardiac conduction
.calcium ion transmembrane transport
.negative regulation of insulin secretion involved in cellular response to glucose stimulus
  + 27 more...
.ion channel binding
.cyclic nucleotide binding
.calcium channel inhibitor activity
  + 3 more...
.calcium channel complex
.sarcoplasmic reticulum membrane
.Z disc
  + 3 more...
73 EBI-10171697,EBI-714680 HBA2  
  .oxidation-reduction process
.protein heterooligomerization
.small molecule metabolic process
  + 6 more...
.heme binding
.oxygen binding
.iron ion binding
.oxygen transporter activity
.blood microparticle
.endocytic vesicle lumen
.extracellular exosome
  + 6 more...
74 EBI-10171697,EBI-10221726 ADAMTSL3  
  .N/A .zinc ion binding
.metallopeptidase activity
.proteinaceous extracellular matrix
75 EBI-10171697,EBI-446479 CYCS  
  .intrinsic apoptotic signaling pathway
.cellular respiration
.small molecule metabolic process
  + 14 more...
.electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity
.heme binding
.iron ion binding
.respiratory chain
.cytosol
.mitochondrial intermembrane space
  + 4 more...
76 EBI-10171697,EBI-10222656 AKAP17A  
  .regulation of RNA splicing
.B cell activation
.RNA splicing
  + 3 more...
.protein kinase A binding
.poly(A) RNA binding
.nucleotide binding
.nuclear speck
.cytoplasm
.spliceosomal complex
  + 2 more...
77 EBI-10171697,EBI-10192698 CREB5  
  .adipose tissue development
.positive regulation of transcription, DNA-templated
.fat cell differentiation
.transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.extracellular exosome
.nucleus
78 EBI-10171697,EBI-711925 ZBTB16  
  .positive regulation of cartilage development
.cartilage development
.positive regulation of NK T cell differentiation
  + 22 more...
.metal ion binding
.protein homodimerization activity
.identical protein binding
  + 4 more...
.transcriptional repressor complex
.nuclear speck
.PML body
  + 5 more...
79 EBI-10171697,EBI-10223946 WT1-AS  
  .N/A .N/A .N/A
80 EBI-10171697,EBI-3951628 TYRO3  
  .platelet aggregation
.neuron cellular homeostasis
.vagina development
  + 20 more...
.phosphatidylinositol 3-kinase binding
.ATP binding
.receptor signaling protein tyrosine kinase activity
  + 2 more...
.integral component of plasma membrane
.endoplasmic reticulum membrane
.nuclear envelope
.nucleus
81 EBI-10171697,EBI-746238 CDK18  
  .N/A .ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.N/A
82 EBI-10171697,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
83 EBI-10171697,EBI-10225757 ZNF844  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
84 EBI-10171697,EBI-2602739 FAM27E3  
  .N/A .N/A .N/A
85 EBI-10171697,EBI-741210 C19orf57  
  .multicellular organismal development .N/A .N/A
86 EBI-10171697,EBI-2349743 TROAP  
  .cell adhesion .N/A .cytoplasm
87 EBI-10171697,EBI-1181405 PRKAA1  
  .negative regulation of glucose import in response to insulin stimulus
.regulation of energy homeostasis
.response to camptothecin
  + 42 more...
.[acetyl-CoA carboxylase] kinase activity
.tau-protein kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
  + 7 more...
.AMP-activated protein kinase complex
.apical plasma membrane
.cytosol
  + 4 more...
88 EBI-10171697,EBI-714236 MTA1  
  .negative regulation of nucleic acid-templated transcription
.positive regulation of protein autoubiquitination
.regulation of inflammatory response
  + 11 more...
.zinc ion binding
.transcription corepressor activity
.transcription coactivator activity
  + 5 more...
.intracellular membrane-bounded organelle
.NuRD complex
.microtubule
  + 4 more...
89 EBI-10171697,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
90 EBI-10171697,EBI-7813714 PKD2  
  .negative regulation of G1/S transition of mitotic cell cycle
.regulation of calcium ion import
.metanephric S-shaped body morphogenesis
  + 45 more...
.phosphoprotein binding
.ATPase binding
.calcium-induced calcium release activity
  + 13 more...
.mitotic spindle
.integral component of lumenal side of endoplasmic reticulum membrane
.integral component of cytoplasmic side of endoplasmic reticulum membrane
  + 16 more...
91 EBI-10171697,EBI-632715 SNW1  
  .cellular response to retinoic acid
.positive regulation of vitamin D receptor signaling pathway
.regulation of vitamin D receptor signaling pathway
  + 19 more...
.SMAD binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 5 more...
.catalytic step 2 spliceosome
.nuclear matrix
.spliceosomal complex
  + 3 more...
92 EBI-10171697,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
93 EBI-10171697,EBI-742350 TCEB3  
  .positive regulation of viral transcription
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.viral process
  + 4 more...
.DNA binding .elongin complex
.integral component of membrane
.cytoplasm
  + 3 more...
94 EBI-10171697,EBI-2515248 FRG1  
  .muscle organ development
.rRNA processing
.mRNA splicing, via spliceosome
.poly(A) RNA binding .catalytic step 2 spliceosome
.Z disc
.Cajal body
.nucleolus
95 EBI-10171697,EBI-739648 KRT81  
  .N/A .structural molecule activity .keratin filament
.extracellular space
96 EBI-10171697,EBI-7115319 ZNF266  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
97 EBI-10171697,EBI-1052105 LAGE3  
  .tRNA processing .N/A .nucleus
98 EBI-10171697,EBI-1221280 KRT72  
  .N/A .structural molecule activity .extracellular exosome
.keratin filament
99 EBI-10171697,EBI-10217913 RTP5  
  .N/A .N/A .integral component of membrane
100 EBI-10171697,EBI-2510602 JOSD1  
  .N/A .omega peptidase activity .membrane
.plasma membrane
.cytoplasm
101 EBI-10171697,EBI-710310 TCEA2  
  .positive regulation of transcription from RNA polymerase II promoter
.regulation of DNA-templated transcription, elongation
.DNA-templated transcription, elongation
.zinc ion binding
.DNA binding
.transcription elongation factor complex
.centrosome
.nucleoplasm
102 EBI-10171697,EBI-10237226 ZFHX3  
  .negative regulation of transcription, DNA-templated
.regulation of neuron differentiation
.positive regulation of myoblast differentiation
  + 7 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding
.enzyme binding
  + 3 more...
.intracellular membrane-bounded organelle
.mitochondrion
.nucleolus
  + 3 more...
103 EBI-10171697,EBI-2555767 ZNF124  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
104 EBI-10171697,EBI-2210673 SSX2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.nucleic acid binding .nucleus
105 EBI-10171697,EBI-6426443 KLHL38  
  .N/A .N/A .N/A
106 EBI-10171697,EBI-2866142 FAM214A  
  .N/A .N/A .N/A
107 EBI-10171697,EBI-10240849 ZNF792  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
108 EBI-10171697,EBI-10241197 TSGA10IP  
  .N/A .N/A .N/A
109 EBI-10171697,EBI-2952676 KRT71  
  .intermediate filament organization
.hair follicle morphogenesis
.structural molecule activity .extracellular exosome
.keratin filament
.cytoplasm
110 EBI-10171697,EBI-740767 ZC2HC1C  
  .N/A .metal ion binding .N/A
111 EBI-10171697,EBI-739879 ALS2CR11  
  .N/A .N/A .N/A
112 EBI-10171697,EBI-10243533 -  
  .N/A .N/A .N/A
113 EBI-10171697,EBI-10243706 ARSI  
  .small molecule metabolic process
.cellular protein metabolic process
.post-translational protein modification
  + 2 more...
.metal ion binding
.arylsulfatase activity
.endoplasmic reticulum lumen
.extracellular region
114 EBI-10171697,EBI-10244057 C6orf226  
  .N/A .N/A .N/A
115 EBI-10171697,EBI-4395687 ZNF569  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
116 EBI-10171697,EBI-10245456 LCE3E  
  .keratinization .N/A .N/A
117 EBI-10171697,EBI-744052 C10orf62  
  .N/A .N/A .N/A
118 EBI-10171697,EBI-8640233 AVPI1  
  .cell cycle
.activation of MAPK activity
.N/A .N/A
119 EBI-10171697,EBI-10246152 SYT6  
  .acrosomal vesicle exocytosis
.calcium ion-dependent exocytosis of neurotransmitter
.regulation of calcium ion-dependent exocytosis
  + 2 more...
.protein homodimerization activity
.clathrin binding
.syntaxin binding
.calcium ion binding
.perinuclear endoplasmic reticulum
.synaptic vesicle membrane
.cell junction
  + 4 more...
120 EBI-10171697,EBI-10247271 FAM74A6  
  .N/A .N/A .N/A
121 EBI-10171697,EBI-10248148 -  
  .N/A .N/A .N/A
122 EBI-10171697,EBI-6447954 TTC23  
  .N/A .N/A .N/A
123 EBI-10171697,EBI-10248548 RNF213  
  .protein autoubiquitination
.protein ubiquitination
.ATPase activity
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.membrane
.cytoplasm
.nucleolus
124 EBI-10171697,EBI-744560 WDR25  
  .N/A .N/A .N/A
125 EBI-10171697,EBI-6660291 C11orf87  
  .N/A .N/A .integral component of membrane
126 EBI-10171697,EBI-2557469 PPP1R18  
  .N/A .N/A .cytoskeleton
.cytoplasm
127 EBI-10171697,EBI-10254820 NAPRT  
  .small molecule metabolic process
.NAD metabolic process
.nicotinate nucleotide salvage
  + 5 more...
.ligase activity
.nicotinate phosphoribosyltransferase activity
.nicotinate-nucleotide diphosphorylase (carboxylating) activity
.extracellular exosome
.cytosol
.Golgi apparatus
  + 3 more...
128 EBI-10171697,EBI-7236323 ZFP2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
129 EBI-10171697,EBI-7844656 TTLL10  
  .cellular protein modification process .N/A .N/A
130 EBI-10171697,EBI-9679267 MOB3C  
  .N/A .metal ion binding .N/A
131 EBI-10171697,EBI-4397613 KCTD9  
  .protein homooligomerization .N/A .N/A
132 EBI-10171697,EBI-10257651 LIMS2  
  .positive regulation of integrin-mediated signaling pathway
.negative regulation of hepatocyte proliferation
.negative regulation of neural precursor cell proliferation
  + 4 more...
.zinc ion binding .focal adhesion
.plasma membrane
.cytosol
.nucleus
133 EBI-10171697,EBI-10258233 CATIP  
  .cilium organization
.actin filament polymerization
.calmodulin binding .actin cytoskeleton
.plasma membrane
.cytoplasm
.nucleus
134 EBI-10171697,EBI-7233259 ZNF329  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
135 EBI-10171697,EBI-10259069 GGN  
  .cell differentiation
.protein localization
.spermatogenesis
  + 2 more...
.N/A .perinuclear region of cytoplasm
.nucleolus
136 EBI-10171697,EBI-308614 CEP57  
  .protein homooligomerization
.microtubule anchoring
.fibroblast growth factor receptor signaling pathway
  + 5 more...
.protein homodimerization activity
.fibroblast growth factor binding
.microtubule cytoskeleton
.microtubule
.cytosol
  + 5 more...
137 EBI-10171697,EBI-10260504 CDC20B  
  .N/A .N/A .N/A
138 EBI-10171697,EBI-6658203 FAM90A1  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
139 EBI-10171697,EBI-10261080 GATAD2A  
  .negative regulation of transcription, DNA-templated
.anterior neuropore closure
.programmed cell death
  + 6 more...
.sequence-specific DNA binding
.protein binding, bridging
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.nuclear speck
.NuRD complex
.nucleoplasm
.nucleus
140 EBI-10171697,EBI-10247802 CCDC146  
  .N/A .N/A .centriole
141 EBI-10171697,EBI-749051 C6orf165  
  .N/A .N/A .N/A
142 EBI-10171697,EBI-1104570 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
143 EBI-10171697,EBI-5278328 ZNF101  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
144 EBI-10171697,EBI-749333 C5orf55  
  .N/A .N/A .extracellular region
145 EBI-10171697,EBI-3439227 ZGPAT  
  .negative regulation of transcription, DNA-templated
.negative regulation of epidermal growth factor-activated receptor activity
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.nucleus
146 EBI-10171697,EBI-1166928 ATPAF2  
  .proton-transporting ATP synthase complex assembly .N/A .nuclear speck
.mitochondrion
147 EBI-10171697,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
148 EBI-10171697,EBI-740814 CCDC185  
  .N/A .N/A .N/A
149 EBI-10171697,EBI-625509 ZNF655  
  .negative regulation of G1/S transition of mitotic cell cycle
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
150 EBI-10171697,EBI-10268729 GOLGA6L2  
  .N/A .N/A .N/A
151 EBI-10171697,EBI-10220600 IQUB  
  .cilium morphogenesis
.smoothened signaling pathway
.N/A .motile cilium
.acrosomal vesicle
152 EBI-10171697,EBI-747580 ZNF439  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
153 EBI-10171697,EBI-745040 CCDC112  
  .N/A .N/A .N/A
154 EBI-10171697,EBI-752049 FAM71C  
  .N/A .N/A .N/A
155 EBI-10171697,EBI-2548605 DOCK8  
  .negative regulation of T cell apoptotic process
.memory T cell proliferation
.dendritic cell migration
  + 3 more...
.guanyl-nucleotide exchange factor activity .cell leading edge
.membrane
.cytosol
156 EBI-10171697,EBI-10271199 NFKBID  
  .positive regulation of thymocyte apoptotic process
.negative regulation of I-kappaB kinase/NF-kappaB signaling
.negative regulation of T cell differentiation in thymus
  + 2 more...
.N/A .nucleus
157 EBI-10171697,EBI-747505 C1orf216  
  .N/A .N/A .N/A
158 EBI-10171697,EBI-10271580 CCDC26  
  .N/A .N/A .N/A
159 EBI-10171697,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
160 EBI-10171697,EBI-742750 BAHD1  
  .negative regulation of transcription, DNA-templated
.heterochromatin assembly
.transcription, DNA-templated
.chromatin silencing
.chromatin binding
.transcription regulatory region sequence-specific DNA binding
.chromatin silencing complex
.nucleoplasm
.chromatin
161 EBI-10171697,EBI-743796 RAB3IL1  
  .positive regulation of GTPase activity
.protein transport
.Rab guanyl-nucleotide exchange factor activity .N/A
162 EBI-10171697,EBI-10273713 ZNF564  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
163 EBI-10171697,EBI-746041 CCER1  
  .N/A .N/A .N/A
164 EBI-10171697,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
165 EBI-10171697,EBI-10244131 FBF1  
  .establishment of epithelial cell polarity
.apical junction assembly
.cilium assembly
.organelle organization
.N/A .ciliary transition fiber
.cell junction
.cytosol
  + 3 more...
166 EBI-10171697,EBI-8637627 AEN  
  .nucleic acid phosphodiester bond hydrolysis
.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.response to ionizing radiation
.exonuclease activity
.nucleic acid binding
.nuclear membrane
.nucleolus
.nucleoplasm
.nucleus
167 EBI-10171697,EBI-7199479 PTPMT1  
  .inositol phosphate dephosphorylation
.glycerophospholipid biosynthetic process
.small molecule metabolic process
  + 4 more...
.phosphatidylglycerophosphatase activity
.protein tyrosine/serine/threonine phosphatase activity
.protein tyrosine phosphatase activity
.phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
.integral component of mitochondrial inner membrane
.mitochondrion
.nucleus
168 EBI-10171697,EBI-367390 RASSF5  
  .regulation of protein localization to nucleus
.intracellular signal transduction
.positive regulation of protein ubiquitination
  + 2 more...
.metal ion binding .microtubule
.cytoplasm
.nucleus
169 EBI-10171697,EBI-488533 ING5  
  .positive regulation of apoptotic signaling pathway
.negative regulation of growth
.positive regulation of transcription, DNA-templated
  + 7 more...
.methylated histone binding
.zinc ion binding
.chromatin binding
.MOZ/MORF histone acetyltransferase complex
.nucleoplasm
.nucleus
170 EBI-10171697,EBI-79084 SHC3  
  .neurotrophin TRK receptor signaling pathway
.synaptic transmission, glutamatergic
.insulin receptor signaling pathway
  + 5 more...
.receptor tyrosine kinase binding
.protein kinase binding
.signal transducer activity
.plasma membrane
.cytosol
171 EBI-10171697,EBI-448771 DOCK2  
  .positive regulation of phagocytosis
.regulation of defense response to virus by virus
.alpha-beta T cell proliferation
  + 12 more...
.T cell receptor binding
.Rac guanyl-nucleotide exchange factor activity
.extracellular exosome
.membrane
.endomembrane system
  + 2 more...
172 EBI-10171697,EBI-1380477 INPP5D  
  .leukocyte migration
.T cell receptor signaling pathway
.negative regulation of immune response
  + 22 more...
.phosphatidylinositol trisphosphate phosphatase activity
.inositol-polyphosphate 5-phosphatase activity
.membrane
.cytosol
173 EBI-10171697,EBI-2802124 NINJ1  
  .hyaloid vascular plexus regression
.tissue regeneration
.nervous system development
  + 2 more...
.N/A .integral component of membrane
174 EBI-10171697,EBI-399080 KAT5  
  .positive regulation of protein acetylation
.cellular response to estradiol stimulus
.positive regulation of transcription from RNA polymerase II promoter
  + 14 more...
.repressing transcription factor binding
.androgen receptor binding
.metal ion binding
  + 2 more...
.perinuclear region of cytoplasm
.NuA4 histone acetyltransferase complex
.Piccolo NuA4 histone acetyltransferase complex
  + 6 more...
175 EBI-10171697,EBI-455078 SMARCE1  
  .negative regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
.metabolic process
  + 4 more...
.protein N-terminus binding
.ligand-dependent nuclear receptor binding
.N-acetyltransferase activity
  + 4 more...
.nBAF complex
.npBAF complex
.protein complex
  + 6 more...
176 EBI-10171697,EBI-366525 POP5  
  .tRNA processing .ribonuclease P activity .nucleolar ribonuclease P complex
177 EBI-10171697,EBI-741068 FBXW5  
  .centrosome duplication
.proteasome-mediated ubiquitin-dependent protein catabolic process
.SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  + 2 more...
.protein kinase binding .Cul4-RING E3 ubiquitin ligase complex
.SCF ubiquitin ligase complex
.cytoplasm
178 EBI-10171697,EBI-746778 MAGOHB  
  .mRNA transport
.RNA splicing
.mRNA processing
.poly(A) RNA binding .catalytic step 2 spliceosome
.exon-exon junction complex
179 EBI-10171697,EBI-745085 PHF21A  
  .chromatin modification
.blood coagulation
.regulation of transcription, DNA-templated
  + 4 more...
.zinc ion binding
.chromatin binding
.DNA binding
.nucleoplasm
.histone deacetylase complex
180 EBI-10171697,EBI-726510 LENG1  
  .N/A .N/A .N/A
181 EBI-10171697,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
182 EBI-10171697,EBI-10286267 MED8  
  .protein ubiquitination
.gene expression
.transcription initiation from RNA polymerase II promoter
.RNA polymerase II transcription cofactor activity .mediator complex
.nucleoplasm
183 EBI-10171697,EBI-748884 LIN37  
  .regulation of cell cycle
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .transcriptional repressor complex
.nucleoplasm
184 EBI-10171697,EBI-10185348 CCDC120  
  .N/A .N/A .N/A
185 EBI-10171697,EBI-751267 PDLIM5  
  .regulation of dendritic spine morphogenesis
.regulation of synapse assembly
.actinin binding
.zinc ion binding
.protein kinase C binding
.actin binding
.postsynaptic membrane
.neuron projection
.cell junction
  + 5 more...
186 EBI-10171697,EBI-4395587 ZNF625  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
187 EBI-10171697,EBI-744859 ANKRD36BP1  
  .N/A .N/A .N/A
188 EBI-10171697,EBI-740773 RBM41  
  .N/A .RNA binding
.nucleotide binding
.N/A
189 EBI-10171697,EBI-2509913 TNIP3  
  .cellular response to lipopolysaccharide
.negative regulation of I-kappaB kinase/NF-kappaB signaling
.toll-like receptor 4 signaling pathway
  + 2 more...
.polyubiquitin binding .N/A
190 EBI-10171697,EBI-751596 C8orf48  
  .N/A .N/A .N/A
191 EBI-10171697,EBI-10291310 HSPA12B  
  .N/A .ATP binding .N/A
192 EBI-10171697,EBI-948288 ZNF488  
  .positive regulation of oligodendrocyte differentiation
.negative regulation of transcription, DNA-templated
.oligodendrocyte development
  + 2 more...
.metal ion binding
.DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
193 EBI-10171697,EBI-2682299 ZMAT2  
  .N/A .zinc ion binding
.DNA binding
.nucleus
194 EBI-10171697,EBI-1046387 TTC25  
  .N/A .N/A .cytoplasm
195 EBI-10171697,EBI-8293751 GUCD1  
  .N/A .N/A .N/A
196 EBI-10171697,EBI-10292528 ZNF317  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
197 EBI-10171697,EBI-747844 RAB3IP  
  .positive regulation of GTPase activity
.cilium assembly
.protein localization to organelle
  + 3 more...
.Rab guanyl-nucleotide exchange factor activity .ciliary basal body
.lamellipodium
.cytoskeleton
  + 3 more...
198 EBI-10171697,EBI-2860740 PRAM1  
  .regulation of neutrophil degranulation
.integrin-mediated signaling pathway
.lipid binding .N/A
199 EBI-10171697,EBI-2908273 PIGS  
  .cellular protein metabolic process
.post-translational protein modification
.attachment of GPI anchor to protein
.C-terminal protein lipidation
.GPI-anchor transamidase activity .GPI-anchor transamidase complex
.membrane
.endoplasmic reticulum membrane
200 EBI-10171697,EBI-6427977 ZNF587  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
201 EBI-10171697,EBI-473181 BARD1  
  .protein K6-linked ubiquitination
.negative regulation of protein export from nucleus
.positive regulation of protein catabolic process
  + 9 more...
.protein heterodimerization activity
.protein homodimerization activity
.kinase binding
  + 4 more...
.BRCA1-A complex
.intracellular membrane-bounded organelle
.BRCA1-BARD1 complex
  + 5 more...
202 EBI-10171697,EBI-2932492 TXN2  
  .oxidation-reduction process
.response to axon injury
.cell redox homeostasis
  + 12 more...
.peptide-methionine (R)-S-oxide reductase activity
.oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
.protein disulfide oxidoreductase activity
.peptide-methionine (S)-S-oxide reductase activity
.neuronal cell body
.dendrite
.mitochondrial matrix
  + 2 more...
203 EBI-10171697,EBI-3916225 FOXB1  
  .cell migration in diencephalon
.inferior colliculus development
.mammary gland lobule development
  + 19 more...
.sequence-specific DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
204 EBI-10171697,EBI-2849569 ZFYVE21  
  .N/A .metal ion binding .cytoplasmic membrane-bounded vesicle
.focal adhesion
.endosome
205 EBI-10171697,EBI-5457544 UTP23  
  .maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) .small ribosomal subunit rRNA binding
.poly(A) RNA binding
.small-subunit processome
.nucleolus
206 EBI-10171697,EBI-2568609 FAM64A  
  .cell division
.mitotic nuclear division
.N/A .cytoplasm
.nucleolus
.nucleus
207 EBI-10171697,EBI-741350 THAP7  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.C2H2 zinc finger domain binding
.protein N-terminus binding
.metal ion binding
.DNA binding
.nuclear speck
.chromosome
208 EBI-10171697,EBI-740781 TCHP  
  .negative regulation of cell growth
.apoptotic process
.N/A .apical cortex
.keratin filament
.plasma membrane
  + 3 more...
209 EBI-10171697,EBI-10298556 LMF2  
  .N/A .N/A .integral component of membrane
.membrane
.endoplasmic reticulum membrane
210 EBI-10171697,EBI-3650647 TRAF4  
  .positive regulation of protein homodimerization activity
.positive regulation of JNK cascade
.positive regulation of protein kinase activity
  + 6 more...
.WW domain binding
.thioesterase binding
.ubiquitin protein ligase binding
  + 4 more...
.perinuclear region of cytoplasm
.tight junction
.plasma membrane
  + 3 more...
211 EBI-10171697,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
212 EBI-10171697,EBI-744935 C20orf195  
  .N/A .N/A .extracellular exosome
213 EBI-10171697,EBI-541426 AP1M1  
  .membrane organization
.regulation of defense response to virus by virus
.endosome to melanosome transport
  + 5 more...
.N/A .extracellular exosome
.trans-Golgi network membrane
.clathrin-coated endocytic vesicle membrane
  + 6 more...
214 EBI-10171697,EBI-745073 BEX2  
  .regulation of cell cycle
.regulation of apoptotic process
.cell cycle
.apoptotic process
.N/A .cytoplasm
.nucleus
215 EBI-10171697,EBI-350510 UACA  
  .regulation of NIK/NF-kappaB signaling
.negative regulation of inflammatory response
.positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
  + 5 more...
.N/A .extracellular exosome
.perinuclear region of cytoplasm
.apoptosome
  + 8 more...
216 EBI-10171697,EBI-10303449 SETD5  
  .N/A .N/A .N/A
217 EBI-10171697,EBI-10303490 SEMA4C  
  .semaphorin-plexin signaling pathway
.muscle cell differentiation
.positive regulation of stress-activated MAPK cascade
  + 3 more...
.receptor activity .postsynaptic membrane
.synaptic vesicle membrane
.cell junction
  + 3 more...
218 EBI-10171697,EBI-928842 NDEL1  
  .neuron projection extension
.neurofilament cytoskeleton organization
.centrosome localization
  + 20 more...
.oligopeptidase activity
.microtubule binding
.neurofilament cytoskeleton
.axon hillock
.cell leading edge
  + 10 more...
219 EBI-10171697,EBI-1050793 SLIRP  
  .mitochondrion morphogenesis
.sperm motility
.single fertilization
  + 4 more...
.poly(A) RNA binding
.nucleotide binding
.perinuclear region of cytoplasm
.sperm flagellum
.ribonucleoprotein complex
  + 3 more...
220 EBI-10171697,EBI-1047335 ISCU  
  .protein maturation by iron-sulfur cluster transfer
.[2Fe-2S] cluster assembly
.small molecule metabolic process
  + 3 more...
.4 iron, 4 sulfur cluster binding
.2 iron, 2 sulfur cluster binding
.iron-sulfur transferase activity
  + 3 more...
.cytosol
.mitochondrial matrix
.mitochondrion
  + 2 more...
221 EBI-10171697,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
222 EBI-10171697,EBI-741626 FAM124B  
  .N/A .N/A .N/A
223 EBI-10171697,EBI-10307654 TMEM231  
  .cilium assembly
.smoothened signaling pathway
.N/A .ciliary membrane
.TCTN-B9D complex
.ciliary transition zone
.integral component of membrane
224 EBI-10171697,EBI-742909 ARMC7  
  .N/A .N/A .cytoplasm
.nucleus
225 EBI-10171697,EBI-747035 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
226 EBI-10171697,EBI-749353 METTL17  
  .translation .methyltransferase activity
.copper ion binding
.ribosome
.mitochondrion
.nucleoplasm
.nucleus
227 EBI-10171697,EBI-10309738 ZNF702P  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
228 EBI-10171697,EBI-10310244 ZNF286A  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
229 EBI-10171697,EBI-712912 CBX8  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 3 more...
.methylated histone binding
.ubiquitin-protein transferase activity
.single-stranded RNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 3 more...
230 EBI-10171697,EBI-740364 NEK6  
  .regulation of cellular senescence
.spindle assembly
.protein autophosphorylation
  + 13 more...
.protein kinase binding
.kinesin binding
.ATP binding
  + 3 more...
.nuclear speck
.microtubule
.cytosol
  + 4 more...
231 EBI-10171697,EBI-9679045 DMRT3  
  .male sex differentiation
.regulation of odontogenesis of dentin-containing tooth
.ventral spinal cord interneuron specification
  + 4 more...
.protein heterodimerization activity
.metal ion binding
.protein homodimerization activity
  + 2 more...
.nucleus
232 EBI-10171697,EBI-8640191 SMCO4  
  .N/A .N/A .integral component of membrane
233 EBI-10171697,EBI-8787464 TBC1D22B  
  .N/A .GTPase activator activity .N/A
234 EBI-10171697,EBI-10313866 C19orf66  
  .N/A .N/A .N/A
235 EBI-10171697,EBI-2859285 C19orf73  
  .N/A .N/A .N/A
236 EBI-10171697,EBI-719816 FBXO34  
  .N/A .N/A .cytoplasm
.nucleoplasm
237 EBI-10171697,EBI-5666657 GPATCH2L  
  .N/A .N/A .N/A
238 EBI-10171697,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
239 EBI-10171697,EBI-743375 CHCHD3  
  .mitochondrial fusion
.inner mitochondrial membrane organization
.negative regulation of transcription from RNA polymerase II promoter
.protein complex scaffold
.phosphatase binding
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.extracellular exosome
.mitochondrial inner membrane
.mitochondrion
  + 2 more...
240 EBI-10171697,EBI-8799578 GFOD1  
  .N/A .oxidoreductase activity .extracellular region
241 EBI-10171697,EBI-745520 ZNF581  
  .transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleus
242 EBI-10171697,EBI-1753397 DLGAP2  
  .neuron-neuron synaptic transmission .N/A .postsynaptic membrane
.cell junction
.postsynaptic density
.neurofilament
243 EBI-10171697,EBI-743428 RCOR3  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.chromatin binding
.DNA binding
.nucleus
244 EBI-10171697,EBI-357355 UXT  
  .centrosome organization
.mitochondrion transport along microtubule
.microtubule cytoskeleton organization
.negative regulation of transcription from RNA polymerase II promoter
.beta-tubulin binding
.microtubule binding
.chromatin binding
.RNA polymerase II transcription corepressor activity
.cytoskeleton
.centrosome
.cytoplasm
.nucleus
245 EBI-10171697,EBI-8636823 CTSZ  
  .epithelial tube branching involved in lung morphogenesis
.proteolysis involved in cellular protein catabolic process
.cellular protein metabolic process
  + 2 more...
.cysteine-type peptidase activity
.cysteine-type endopeptidase activity
.extracellular exosome
.intracellular membrane-bounded organelle
.plasma membrane
  + 3 more...
246 EBI-10171697,EBI-398874 NXF1  
  .poly(A)+ mRNA export from nucleus
.viral process
.gene expression
.mRNA export from nucleus
.poly(A) RNA binding
.nucleocytoplasmic transporter activity
.mRNA binding
.nucleotide binding
.nuclear inclusion body
.nuclear speck
.cytosol
  + 2 more...
247 EBI-10171697,EBI-750394 SLC25A10  
  .sulfide oxidation, using sulfide:quinone oxidoreductase
.transmembrane transport
.small molecule metabolic process
  + 9 more...
.dicarboxylic acid transmembrane transporter activity .integral component of membrane
.mitochondrial inner membrane
.nucleus
248 EBI-10171697,EBI-10320765 POLL  
  .somatic hypermutation of immunoglobulin genes
.nucleotide-excision repair
.DNA replication
.metal ion binding
.lyase activity
.DNA-directed DNA polymerase activity
.DNA binding
.nucleus
249 EBI-10171697,EBI-748350 RTDR1  
  .N/A .N/A .N/A
250 EBI-10171697,EBI-1105361 ZNF230  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
251 EBI-10171697,EBI-2686537 SCOC  
  .positive regulation of macroautophagy .N/A .cytosol
.Golgi membrane
252 EBI-10171697,EBI-10322364 ZFP69B  
  .transcription, DNA-templated .metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
253 EBI-10171697,EBI-373242 USP21  
  .regulation of proteasomal protein catabolic process
.positive regulation of transcription, DNA-templated
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 3 more...
.metal ion binding
.NEDD8-specific protease activity
.cysteine-type peptidase activity
  + 3 more...
.plasma membrane
.cytoplasm
.nucleoplasm
254 EBI-10171697,EBI-741528 CHIC2  
  .Golgi to plasma membrane transport .N/A .plasma membrane
.Golgi-associated vesicle
255 EBI-10171697,EBI-717201 SPG7  
  .anterograde axon cargo transport
.nervous system development
.mitochondrion organization
.proteolysis
.unfolded protein binding
.zinc ion binding
.peptidase activity
  + 2 more...
.mitochondrial membrane
.integral component of membrane
.mitochondrion
256 EBI-10171697,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
257 EBI-10171697,EBI-5453723 MRPL11  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 3 more...
.poly(A) RNA binding
.structural constituent of ribosome
.mitochondrial ribosome
.mitochondrial inner membrane
258 EBI-10171697,EBI-714987 ZNF337  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
259 EBI-10171697,EBI-740053 SPEF1  
  .N/A .N/A .motile cilium
.axoneme
.cytoskeleton
260 EBI-10171697,EBI-6659161 MAB21L2  
  .camera-type eye development
.embryonic body morphogenesis
.positive regulation of cell proliferation
  + 2 more...
.N/A .nucleus
261 EBI-10171697,EBI-10281938 ZSCAN21  
  .positive regulation of transcription from RNA polymerase II promoter
.regulation of transcription, DNA-templated
.metal ion binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleus
262 EBI-10171697,EBI-1045409 GTF3C5  
  .tRNA transcription from RNA polymerase III promoter
.5S class rRNA transcription from RNA polymerase III type 1 promoter
.skeletal muscle cell differentiation
  + 3 more...
.DNA binding .nucleoplasm
.transcription factor TFIIIC complex
263 EBI-10171697,EBI-2321769 CHCHD2  
  .regulation of cellular response to hypoxia
.positive regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.sequence-specific DNA binding
.transcription factor binding
.mitochondrion
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
heart22
mammary gland6
pituitary gland181
testis2
trachea38
Health State
TissuesTPM*
normal1
Developmental Stage
TissuesTPM*
fetus3
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center