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> Protein (NX_Q6BCY4)
Protein (NX_Q6BCY4)
Protein
Gene SymbolCYB5R2 to neXtProt (NX_Q6BCY4)
DescriptionNADH-cytochrome b5 reductase 2
Chromosome11
Location11p15.4 (7686331 ~ 7698453) to Ensembl
Sequene Features : Isoforms 2, Variants 50, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.oxidation-reduction process
.sterol biosynthetic process
.cytochrome-b5 reductase activity, acting on NAD(P)H .membrane
.mitochondrion
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 50 0
2014-09-19protein level
2 44 0
2014-05-27protein level
2 44 0
2014-02-25protein level
2 45 0
2013-12-09protein level
2 36 0
2013-11-01protein level
2 33 0
2013-09-12protein level
2 33 0
2013-08-17protein level
2 33 0
2013-07-15protein level
2 27 0
2013-06-11protein level
2 27 0
2013-02-12protein level
2 20 2
2012-12-20protein level
2 19 2
2012-10-30protein level
2 21 2
2012-10-07protein level
2 21 1
2012-08-24protein level
2 19 1
2012-07-28protein level
2 19 1
2012-06-08protein level
2 21 1
2012-05-07protein level
2 21 1
2012-04-10protein level
2 21 1
2012-01-13protein level
2 11 1
2011-12-20protein level
2 11 1
2011-11-11protein level
2 11 1
2011-08-23protein level
2 11 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q6BCY4-1
5 12 0 31438.2819
NX_Q6BCY4-2
1 12 0 27025.9551
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-744761,EBI-357669 PSMC6  
  .positive regulation of proteasomal protein catabolic process
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
  + 25 more...
.proteasome-activating ATPase activity
.protein binding, bridging
.TBP-class protein binding
  + 2 more...
.extracellular exosome
.cytosolic proteasome complex
.nuclear proteasome complex
  + 7 more...
2 EBI-744761,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
3 EBI-744761,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
4 EBI-744761,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
5 EBI-744761,EBI-358993 TRIP13  
  .regulation of nucleic acid-templated transcription
.oogenesis
.spermatid development
  + 8 more...
.identical protein binding
.ATP binding
.transcription cofactor activity
.nucleus
.male germ cell nucleus
6 EBI-744761,EBI-396137 CDC23  
  .protein K11-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 11 more...
.ubiquitin-protein transferase activity .cytosol
.anaphase-promoting complex
.nucleoplasm
.intracellular
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
bone13
brain29
connective tissue6
embryonic tissue32
eye33
heart22
intestine21
larynx42
liver9
lung38
lymph node22
mammary gland26
parathyroid48
placenta10
prostate10
salivary gland49
skin28
testis142
trachea19
uterus21
Health State
TissuesTPM*
normal23
breast (mammary gland) tumor10
chondrosarcoma12
colorectal tumor8
gastrointestinal tumor16
germ cell tumor26
glioma27
head and neck tumor7
leukemia10
liver tumor10
lung tumor19
non-neoplasia20
skin tumor39
soft tissue/muscle tissue tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult21
blastocyst81
fetus14
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.8
adrenal gland4
appendix7.2
bone marrow3.3
cerebral cortex13.5
colon5.5
duodenum2.8
esophagus14.7
gallbladder8.1
heart muscle2.5
kidney3.8
liver5
lung9.4
lymph node2.8
ovary31.7
pancreas2.7
placenta16.1
prostate13
salivary gland16.2
skin40
small intestine3.1
spleen1.8
stomach4.7
testis111.6
thyroid gland5
urinary bladder13
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608342, gene) Cytochrome b5 reductase 2; CYB5R2OMIM


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