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> Protein (NX_Q6IQ55)
Protein (NX_Q6IQ55)
Protein
Gene SymbolTTBK2 to neXtProt (NX_Q6IQ55)
DescriptionTau-tubulin kinase 2
Chromosome15
Location15q15.2 (43030932 ~ 43213007) to Ensembl
Sequene Features : Isoforms 3, Variants 126, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cilium assembly
.peptidyl-serine phosphorylation
.regulation of cell shape
  + 2 more...
.ATP binding
.protein serine/threonine kinase activity
.ciliary basal body
.ciliary transition zone
.cytosol
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 126 2
2014-09-19protein level
3 92 2
2014-05-27protein level
3 92 2
2014-02-25protein level
3 92 2
2013-12-09protein level
3 60 2
2013-11-01protein level
3 59 2
2013-09-12protein level
3 59 2
2013-08-17protein level
3 59 2
2013-07-15protein level
3 45 2
2013-06-11protein level
3 45 2
2013-02-12protein level
3 21 2
2012-12-20protein level
3 21 2
2012-10-30protein level
3 29 2
2012-10-07protein level
3 29 1
2012-08-24protein level
3 23 1
2012-07-28protein level
3 23 1
2012-06-08protein level
3 14 1
2012-05-07protein level
3 14 1
2012-04-10protein level
3 14 1
2012-01-13protein level
3 14 1
2011-12-20protein level
3 14 1
2011-11-11protein level
3 14 1
2011-08-23protein level
3 14 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q6IQ55-1
0 55 4 137327.2997
NX_Q6IQ55-2
0 53 3 129029.6128
NX_Q6IQ55-3
0 18 4 54002.6588
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1050303,EBI-740929 KLHL12  
  .negative regulation of canonical Wnt signaling pathway
.COPII vesicle coating
.Wnt signaling pathway
  + 2 more...
.N/A .Cul3-RING ubiquitin ligase complex
.ER to Golgi transport vesicle
.cytosol
.Golgi membrane
2 EBI-1050303,EBI-3937015 CEP164  
  .cell division
.cilium assembly
.mitotic nuclear division
  + 4 more...
.N/A .ciliary transition fiber
.cytosol
.centriole
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone13
brain9
cervix144
embryonic tissue14
heart22
intestine4
liver9
lung29
lymph node77
mouth15
muscle18
pancreas14
placenta24
skin9
testis52
thymus12
thyroid42
Health State
TissuesTPM*
normal17
cervical tumor28
esophageal tumor57
germ cell tumor7
glioma9
head and neck tumor14
liver tumor10
lung tumor19
lymphoma13
primitive neuroectodermal tumor of the CNS15
skin tumor15
Developmental Stage
TissuesTPM*
adult1
embryoid body14
blastocyst16
fetus7
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.5
adrenal gland5
appendix3.3
bone marrow3.1
cerebral cortex9.5
colon2.9
duodenum1.6
esophagus2.8
gallbladder4.3
heart muscle5.2
kidney4
liver1.4
lung3.9
lymph node3.5
ovary6.5
pancreas1.3
placenta4.9
prostate4.6
salivary gland1.8
skin3
small intestine2.1
spleen4.3
stomach2.5
testis26.6
thyroid gland4
urinary bladder3.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#604432, phenotype) Spinocerebellar ataxia 11; SCA11OMIM
2(*611695, gene) Tau tubulin kinase 2; TTBK2OMIM


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