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> Protein (NX_Q6N021)
Protein (NX_Q6N021)
Protein
Gene SymbolTET2 to neXtProt (NX_Q6N021)
DescriptionMethylcytosine dioxygenase TET2
Chromosome4
Location4q24 (106067032 ~ 106200973) to Ensembl
Sequene Features : Isoforms 3, Variants 418, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.histone H3-K4 trimethylation
.DNA demethylation
.liver morphogenesis
  + 15 more...
.methylcytosine dioxygenase activity
.zinc ion binding
.ferrous iron binding
.DNA binding
.N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 418 5
2014-09-19protein level
3 334 5
2014-05-27protein level
3 334 5
2014-02-25protein level
3 331 4
2013-12-09protein level
3 302 4
2013-11-01protein level
3 286 4
2013-09-12protein level
3 286 4
2013-08-17protein level
3 286 4
2013-07-15protein level
3 241 4
2013-06-11protein level
3 241 4
2013-02-12protein level
3 203 13
2012-12-20protein level
3 203 13
2012-10-30protein level
3 219 13
2012-10-07protein level
3 219 5
2012-08-24protein level
3 210 5
2012-07-28protein level
3 210 5
2012-06-08protein level
3 102 5
2012-05-07protein level
3 102 5
2012-04-10protein level
3 102 5
2012-01-13protein level
3 93 5
2011-12-20protein level
3 93 5
2011-11-11protein level
3 93 5
2011-08-23protein level
3 93 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q6N021-1
34 54 2 223670.3497
NX_Q6N021-2
1 54 0 130172.3954
NX_Q6N021-3
2 54 0 133397.5878
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-310727,EBI-539828 OGT  
  .regulation of gluconeogenesis involved in cellular glucose homeostasis
.histone H3-K4 trimethylation
.cellular response to retinoic acid
  + 21 more...
.protein O-GlcNAc transferase activity
.protein N-acetylglucosaminyltransferase activity
.acetylglucosaminyltransferase activity
  + 2 more...
.MLL5-L complex
.plasma membrane
.cytosol
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood220
bone13
brain11
connective tissue13
ear124
embryonic tissue18
eye14
heart11
kidney4
liver4
lung11
lymph22
lymph node33
mammary gland727
mouth272
muscle9
pancreas32
pharynx24
pituitary gland60
placenta24
prostate5
salivary gland49
skin9
spleen18
stomach10
testis2
uterus25
Health State
TissuesTPM*
normal16
breast (mammary gland) tumor1138
chondrosarcoma24
gastrointestinal tumor8
germ cell tumor3
head and neck tumor141
leukemia264
liver tumor10
lung tumor19
lymphoma13
non-neoplasia51
primitive neuroectodermal tumor of the CNS7
soft tissue/muscle tissue tumor7
uterine tumor44
Developmental Stage
TissuesTPM*
adult2
embryoid body42
fetus14
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.1
adrenal gland3.7
appendix11.3
bone marrow27
cerebral cortex4.5
colon6
duodenum6.1
esophagus9
gallbladder6.4
heart muscle3.2
kidney4.5
liver3.1
lung5.5
lymph node5.6
ovary6.3
pancreas1.9
placenta9.5
prostate5.1
salivary gland3.8
skin9.6
small intestine6.5
spleen7.4
stomach5.3
testis1.6
thyroid gland4.8
urinary bladder7.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#263300, phenotype) Polycythemia veraOMIM
2(*612839, gene) Tet oncogene family, member 2; TET2OMIM
3(#614286, phenotype) Myelodysplastic syndrome; MDSOMIM
4myelodysplastic syndromeCGP


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