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> Protein (NX_Q6NT76)
Protein (NX_Q6NT76)
Protein
Gene SymbolHMBOX1 to neXtProt (NX_Q6NT76)
DescriptionHomeobox-containing protein 1
Chromosome8
Location8p12 (28747911 ~ 28922281) to Ensembl
Sequene Features : Isoforms 5, Variants 38, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .cytoplasm
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 38 1
2014-09-19protein level
5 23 1
2014-05-27protein level
5 23 1
2014-02-25protein level
5 21 1
2013-12-09protein level
5 21 1
2013-11-01protein level
5 20 1
2013-09-12protein level
5 20 1
2013-08-17protein level
5 20 1
2013-07-15protein level
5 10 1
2013-06-11protein level
5 10 1
2013-02-12protein level
5 2 5
2012-12-20protein level
5 2 5
2012-10-30protein level
5 2 5
2012-10-07protein level
5 2 1
2012-08-24protein level
5 2 1
2012-07-28protein level
5 2 1
2012-06-08protein level
5 3 1
2012-05-07protein level
5 2 1
2012-04-10protein level
5 2 1
2012-01-13protein level
5 6 1
2011-12-20protein level
5 6 1
2011-11-11protein level
5 6 0
2011-08-23protein level
5 6 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q6NT76-1
1 13 1 47248.9632
NX_Q6NT76-2
0 15 1 45952.3506
NX_Q6NT76-3
1 13 1 47048.884
NX_Q6NT76-4
1 11 0 34606.9233
NX_Q6NT76-5
1 15 1 49836.1206
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2549423,EBI-5282516 UBA6  
  .protein ubiquitination
.ubiquitin-dependent protein catabolic process
.FAT10 activating enzyme activity
.ATP binding
.cytosol
.cytoplasm
2 EBI-2549423,EBI-10177044 NPIPA7  
  .N/A .N/A .N/A
3 EBI-2549423,EBI-744471 ZBTB24  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.hematopoietic progenitor cell differentiation
.metal ion binding
.DNA binding
.nucleus
4 EBI-2549423,EBI-713091 DKC1  
  .mRNA pseudouridine synthesis
.snRNA pseudouridine synthesis
.rRNA pseudouridine synthesis
  + 6 more...
.poly(A) RNA binding
.pseudouridine synthase activity
.RNA binding
.telomerase activity
.box H/ACA snoRNP complex
.Cajal body
.cytoplasm
  + 4 more...
5 EBI-2549423,EBI-7875264 DAB1  
  .lateral motor column neuron migration
.Golgi localization
.negative regulation of axonogenesis
  + 15 more...
.N/A .perinuclear region of cytoplasm
.apical part of cell
.neuronal cell body
  + 5 more...
6 EBI-2549423,EBI-2513774 FARS2  
  .gene expression
.tRNA processing
.phenylalanyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.phenylalanine-tRNA ligase activity
.magnesium ion binding
.tRNA binding
.mitochondrial matrix
.mitochondrion
7 EBI-2549423,EBI-1053651 SNRPB2  
  .gene expression
.RNA splicing
.mRNA processing
  + 2 more...
.snRNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.nucleolus
.U2 snRNP
  + 2 more...
8 EBI-2549423,EBI-353208 XRCC6  
  .establishment of integrated proviral latency
.cellular response to X-ray
.cellular hyperosmotic salinity response
  + 16 more...
.5'-deoxyribose-5-phosphate lyase activity
.poly(A) RNA binding
.transcription regulatory region DNA binding
  + 7 more...
.nonhomologous end joining complex
.Ku70:Ku80 complex
.membrane
  + 6 more...
9 EBI-2549423,EBI-358122 RPL9  
  .cellular protein metabolic process
.viral transcription
.viral life cycle
  + 8 more...
.rRNA binding
.structural constituent of ribosome
.RNA binding
.cytosolic large ribosomal subunit
.membrane
.focal adhesion
  + 5 more...
10 EBI-2549423,EBI-355815 ATP5O  
  .small molecule metabolic process
.cellular metabolic process
.mitochondrial ATP synthesis coupled proton transport
  + 3 more...
.proton-transporting ATP synthase activity, rotational mechanism
.transmembrane transporter activity
.drug binding
.transporter activity
.extracellular exosome
.plasma membrane
.mitochondrial proton-transporting ATP synthase complex
  + 3 more...
11 EBI-10212206,EBI-740459 FXR2  
  .negative regulation of translation
.positive regulation of defense response to virus by host
.poly(A) RNA binding
.identical protein binding
.mRNA binding
.RNA binding
.extracellular exosome
.cytosolic large ribosomal subunit
.membrane
  + 3 more...
12 EBI-2549423,EBI-3905829 CCNG1  
  .cell division
.negative regulation of apoptotic process
.cell growth
  + 6 more...
.N/A .perinuclear region of cytoplasm
.neuronal cell body
.dendrite
.nucleus
13 EBI-2549423,EBI-1383852 PRKAA2  
  .regulation of energy homeostasis
.membrane organization
.fatty acid homeostasis
  + 31 more...
.[acetyl-CoA carboxylase] kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
.metal ion binding
  + 7 more...
.AMP-activated protein kinase complex
.cytosol
.cytoplasm
.nucleoplasm
14 EBI-2549423,EBI-1048159 MFAP1  
  .extracellular matrix organization .poly(A) RNA binding .extracellular region
.microfibril
15 EBI-2549423,EBI-947090 PIP4K2B  
  .phosphatidylinositol phosphorylation
.small molecule metabolic process
.intracellular signal transduction
  + 3 more...
.1-phosphatidylinositol-5-phosphate 4-kinase activity
.1-phosphatidylinositol-4-phosphate 5-kinase activity
.ATP binding
.receptor signaling protein activity
.plasma membrane
.cytosol
.endoplasmic reticulum membrane
.nucleoplasm
16 EBI-2549423,EBI-723426 MRPL28  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 3 more...
.poly(A) RNA binding
.structural constituent of ribosome
.mitochondrial ribosome
.mitochondrial inner membrane
.mitochondrion
  + 2 more...
17 EBI-2549423,EBI-1181405 PRKAA1  
  .negative regulation of glucose import in response to insulin stimulus
.regulation of energy homeostasis
.response to camptothecin
  + 42 more...
.[acetyl-CoA carboxylase] kinase activity
.tau-protein kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
  + 7 more...
.AMP-activated protein kinase complex
.apical plasma membrane
.cytosol
  + 4 more...
18 EBI-2549423,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
19 EBI-2549423,EBI-399189 VPS72  
  .somatic stem cell maintenance
.chromatin modification
.transcription, DNA-templated
  + 2 more...
.DNA binding .protein complex
.nucleoplasm
.nucleus
20 EBI-2549423,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
21 EBI-2549423,EBI-10247271 FAM74A6  
  .N/A .N/A .N/A
22 EBI-2549423,EBI-10255023 AEBP2  
  .negative regulation of gene expression, epigenetic
.regulation of gene expression, epigenetic
.chromatin modification
  + 2 more...
.metal ion binding
.transcription corepressor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.ESC/E(Z) complex
.nucleoplasm
23 EBI-10212206,EBI-1104535 SFR1  
  .double-strand break repair via homologous recombination .N/A .Swi5-Sfr1 complex
.nucleus
24 EBI-2549423,EBI-954696 TCEANC  
  .regulation of DNA-templated transcription, elongation
.regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.DNA binding .nucleus
25 EBI-2549423,EBI-751248 FAM13C  
  .N/A .N/A .N/A
26 EBI-2549423,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
27 EBI-2549423,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
28 EBI-2549423,EBI-399080 KAT5  
  .positive regulation of protein acetylation
.cellular response to estradiol stimulus
.positive regulation of transcription from RNA polymerase II promoter
  + 14 more...
.repressing transcription factor binding
.androgen receptor binding
.metal ion binding
  + 2 more...
.perinuclear region of cytoplasm
.NuA4 histone acetyltransferase complex
.Piccolo NuA4 histone acetyltransferase complex
  + 6 more...
29 EBI-2549423,EBI-742371 DYNLL2  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.antigen processing and presentation of exogenous peptide antigen via MHC class II
  + 6 more...
.motor activity .ciliary tip
.primary cilium
.dynein complex
  + 7 more...
30 EBI-10212206,EBI-750345 REEP6  
  .regulation of intracellular transport .N/A .apical part of cell
.rod spherule
.integral component of membrane
  + 2 more...
31 EBI-2549423,EBI-2682299 ZMAT2  
  .N/A .zinc ion binding
.DNA binding
.nucleus
32 EBI-2549423,EBI-741729 FRMD6  
  .cellular protein localization
.regulation of actin filament-based process
.apical constriction
.N/A .apical junction complex
.plasma membrane
.cytoskeleton
.cytoplasm
33 EBI-2549423,EBI-6427977 ZNF587  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
34 EBI-2549423,EBI-744935 C20orf195  
  .N/A .N/A .extracellular exosome
35 EBI-2549423,EBI-473834 MAGEH1  
  .apoptotic process .N/A .cytoplasm
36 EBI-2549423,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
37 EBI-2549423,EBI-3916346 ASB7  
  .intracellular signal transduction
.protein ubiquitination
.N/A .N/A
38 EBI-2549423,EBI-747035 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
39 EBI-2549423,EBI-715389 C8orf33  
  .N/A .N/A .N/A
40 EBI-2549423,EBI-720977 UBE2Z  
  .apoptotic process
.protein polyubiquitination
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
.ubiquitin-like protein transferase activity
  + 2 more...
.cytoplasm
.nucleoplasm
41 EBI-2549423,EBI-2340040 SAP30L  
  .negative regulation of gene expression, epigenetic
.regulation of gene expression, epigenetic
.gene expression
  + 3 more...
.metal ion binding
.DNA binding
.nucleolus
.nucleoplasm
42 EBI-2549423,EBI-712912 CBX8  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 3 more...
.methylated histone binding
.ubiquitin-protein transferase activity
.single-stranded RNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 3 more...
43 EBI-2549423,EBI-9105722 FAM206A  
  .N/A .N/A .nuclear speck
44 EBI-2549423,EBI-745520 ZNF581  
  .transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleus
45 EBI-10212206,EBI-399246 MORF4L1  
  .histone H2A acetylation
.histone H4 acetylation
.regulation of growth
  + 6 more...
.protein N-terminus binding
.chromatin binding
.NuA4 histone acetyltransferase complex
.Sin3 complex
.nucleoplasm
46 EBI-2549423,EBI-5453723 MRPL11  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 3 more...
.poly(A) RNA binding
.structural constituent of ribosome
.mitochondrial ribosome
.mitochondrial inner membrane
47 EBI-2549423,EBI-714987 ZNF337  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bladder33
blood32
bone55
brain1
connective tissue13
embryonic tissue28
eye14
intestine21
kidney4
liver4
lung17
lymph node33
mammary gland26
ovary19
pancreas37
pharynx24
placenta38
prostate15
salivary gland49
skin18
stomach20
testis6
thymus12
thyroid42
trachea57
vascular19
Health State
TissuesTPM*
normal26
breast (mammary gland) tumor10
chondrosarcoma60
colorectal tumor17
gastrointestinal tumor16
germ cell tumor11
glioma9
head and neck tumor7
leukemia42
liver tumor20
lung tumor9
non-neoplasia31
ovarian tumor26
pancreatic tumor19
primitive neuroectodermal tumor of the CNS118
prostate cancer28
skin tumor7
Developmental Stage
TissuesTPM*
adult3
embryoid body42
blastocyst16
fetus3
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.8
adrenal gland16.3
appendix10.6
bone marrow11.3
cerebral cortex10.8
colon8.5
duodenum4.9
esophagus5.8
gallbladder8
heart muscle7
kidney8
liver4.2
lung11.8
lymph node12.1
ovary11.4
pancreas3.9
placenta10.7
prostate6.4
salivary gland6.3
skin12.8
small intestine7.5
spleen12.9
stomach7.6
testis14.3
thyroid gland11.1
urinary bladder6.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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