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> Protein (NX_Q6NUQ1)
Protein (NX_Q6NUQ1)
Protein
Gene SymbolRINT1 to neXtProt (NX_Q6NUQ1)
DescriptionRAD50-interacting protein 1
Chromosome7
Location7q22.3 (105172532 ~ 105208124) to Ensembl
Sequene Features : Isoforms 1, Variants 85, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
.regulation of ER to Golgi vesicle-mediated transport
.Golgi vesicle transport
  + 2 more...
.N/A .endoplasmic reticulum membrane
.endoplasmic reticulum
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 85 0
2014-09-19protein level
1 64 0
2014-05-27protein level
1 64 0
2014-02-25protein level
1 63 0
2013-12-09protein level
1 49 0
2013-11-01protein level
1 48 0
2013-09-12protein level
1 48 0
2013-08-17protein level
1 48 0
2013-07-15protein level
1 31 0
2013-06-11protein level
1 31 0
2013-02-12protein level
1 20 0
2012-12-20protein level
1 20 0
2012-10-30protein level
1 24 0
2012-10-07protein level
1 24 0
2012-08-24protein level
1 24 0
2012-07-28protein level
1 24 0
2012-06-08protein level
1 27 0
2012-05-07protein level
1 20 0
2012-04-10protein level
1 20 0
2012-01-13protein level
1 9 0
2011-12-20protein level
1 9 0
2011-11-11protein level
1 9 0
2011-08-23protein level
1 9 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q6NUQ1-1
30 0 0 90573.3008
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-726876,EBI-2559305 VPS37C  
  .intracellular transport of virus
.membrane organization
.viral protein processing
  + 5 more...
.calcium-dependent protein binding .extracellular exosome
.late endosome membrane
.endosome membrane
.ESCRT I complex
2 EBI-726876,EBI-346930 PIK3R2  
  .regulation of small GTPase mediated signal transduction
.leukocyte migration
.T cell receptor signaling pathway
  + 25 more...
.protein heterodimerization activity
.1-phosphatidylinositol-3-kinase regulator activity
.receptor tyrosine kinase binding
.protein phosphatase binding
.phosphatidylinositol 3-kinase complex
.cytosol
.nucleus
3 EBI-726876,EBI-8646694 DCX  
  .dendrite morphogenesis
.axon extension
.protein autophosphorylation
  + 8 more...
.protein kinase binding
.calcium-dependent protein serine/threonine kinase activity
.microtubule binding
  + 2 more...
.neuron projection
.microtubule associated complex
.microtubule
  + 4 more...
4 EBI-726876,EBI-1046642 STRN  
  .tight junction assembly
.dendrite development
.Wnt signaling pathway
  + 2 more...
.armadillo repeat domain binding
.protein phosphatase 2A binding
.protein complex binding
  + 2 more...
.postsynaptic membrane
.dendritic spine
.neuronal cell body
  + 4 more...
5 EBI-726876,EBI-10192902 FAM107A  
  .regulation of cell growth .N/A .neuron projection
.nucleus
6 EBI-726876,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
7 EBI-726876,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
8 EBI-726876,EBI-308629 HDAC4  
  .histone H4 deacetylation
.histone H3 deacetylation
.response to interleukin-1
  + 29 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 12 more...
.actomyosin
.A band
.neuromuscular junction
  + 7 more...
9 EBI-726876,EBI-632715 SNW1  
  .cellular response to retinoic acid
.positive regulation of vitamin D receptor signaling pathway
.regulation of vitamin D receptor signaling pathway
  + 19 more...
.SMAD binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 5 more...
.catalytic step 2 spliceosome
.nuclear matrix
.spliceosomal complex
  + 3 more...
10 EBI-726876,EBI-10217913 RTP5  
  .N/A .N/A .integral component of membrane
11 EBI-726876,EBI-10239122 CSPP1  
  .positive regulation of cell division
.positive regulation of cytokinesis
.N/A .microtubule
.spindle
.centrosome
  + 3 more...
12 EBI-726876,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
13 EBI-726876,EBI-2836982 CCDC121  
  .N/A .N/A .N/A
14 EBI-726876,EBI-10256202 RSRC2  
  .N/A .poly(A) RNA binding .N/A
15 EBI-726876,EBI-1104535 SFR1  
  .double-strand break repair via homologous recombination .N/A .Swi5-Sfr1 complex
.nucleus
16 EBI-726876,EBI-6658203 FAM90A1  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
17 EBI-726876,EBI-10247802 CCDC146  
  .N/A .N/A .centriole
18 EBI-726876,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
19 EBI-726876,EBI-10265323 RIBC1  
  .N/A .N/A .N/A
20 EBI-726876,EBI-625509 ZNF655  
  .negative regulation of G1/S transition of mitotic cell cycle
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
21 EBI-726876,EBI-455078 SMARCE1  
  .negative regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
.metabolic process
  + 4 more...
.protein N-terminus binding
.ligand-dependent nuclear receptor binding
.N-acetyltransferase activity
  + 4 more...
.nBAF complex
.npBAF complex
.protein complex
  + 6 more...
22 EBI-726876,EBI-743117 CCDC101  
  .establishment of protein localization to chromatin
.histone H3 acetylation
.regulation of transcription, DNA-templated
  + 2 more...
.methylated histone binding .SAGA-type complex
.Ada2/Gcn5/Ada3 transcription activator complex
23 EBI-726876,EBI-740773 RBM41  
  .N/A .RNA binding
.nucleotide binding
.N/A
24 EBI-726876,EBI-10290827 FAM81B  
  .N/A .N/A .nucleus
25 EBI-726876,EBI-1752811 FAM110A  
  .N/A .N/A .microtubule organizing center
.cytoplasm
.spindle pole
26 EBI-726876,EBI-748391 SCNM1  
  .RNA splicing
.mRNA processing
.metal ion binding
.enzyme binding
.nuclear speck
.nucleolus
.nucleus
27 EBI-726876,EBI-769270 EPC1  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
  + 7 more...
.N/A .NuA4 histone acetyltransferase complex
.Piccolo NuA4 histone acetyltransferase complex
.nuclear membrane
  + 2 more...
28 EBI-726876,EBI-741626 FAM124B  
  .N/A .N/A .N/A
29 EBI-726876,EBI-747035 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
30 EBI-726876,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder33
blood40
bone13
bone marrow82
brain45
cervix103
connective tissue93
embryonic tissue42
esophagus49
eye28
heart22
intestine8
kidney42
liver77
lung2
lymph node89
mammary gland52
mouth60
muscle18
pancreas18
pharynx24
placenta24
prostate31
skin47
spleen18
testis66
thymus50
thyroid21
trachea77
uterus25
Health State
TissuesTPM*
normal35
breast (mammary gland) tumor64
cervical tumor144
chondrosarcoma12
esophageal tumor57
gastrointestinal tumor16
germ cell tumor68
glioma9
head and neck tumor22
kidney tumor43
leukemia95
liver tumor114
lung tumor9
lymphoma83
non-neoplasia51
primitive neuroectodermal tumor of the CNS39
prostate cancer28
retinoblastoma64
skin tumor39
soft tissue/muscle tissue tumor71
uterine tumor33
Developmental Stage
TissuesTPM*
adult31
embryoid body28
blastocyst48
neonate32
fetus62
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.5
adrenal gland8
appendix11.8
bone marrow19.3
cerebral cortex9.3
colon9.6
duodenum8.9
esophagus12.5
gallbladder9.4
heart muscle7.2
kidney8.1
liver7.1
lung9.8
lymph node14.3
ovary8.4
pancreas6.6
placenta9.2
prostate9.2
salivary gland8.6
skin11.5
small intestine7.5
spleen10
stomach10.9
testis12.4
thyroid gland10.2
urinary bladder8.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexMedium
colonMedium
duodenumMedium
fallopian tubeHigh
gallbladderMedium
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleMedium
liverMedium
lungLow
nasopharynxMedium
ovaryMedium
pancreasLow
parathyroid glandLow
placentaLow
prostateLow
rectumMedium
salivary glandLow
skeletal muscleMedium
skin 2Low
small intestineMedium
soft tissue 2Medium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
tonsilMedium
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610089, gene) Rad50-interacting protein 1; RINT1OMIM


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