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> Protein (NX_Q6NYC1)
Protein (NX_Q6NYC1)
Protein
Gene SymbolJMJD6 to neXtProt (NX_Q6NYC1)
DescriptionBifunctional arginine demethylase and lysyl-hydroxylase JMJD6
Chromosome17
Location17q25.1 (74708919 ~ 74722866) to Ensembl
Sequene Features : Isoforms 3, Variants 35, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.histone H4-R3 demethylation
.histone H3-R2 demethylation
.retina development in camera-type eye
  + 15 more...
.peptidyl-lysine 5-dioxygenase activity
.identical protein binding
.histone demethylase activity (H4-R3 specific)
  + 5 more...
.plasma membrane
.nucleolus
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 35 2
2014-09-19protein level
3 24 2
2014-05-27protein level
3 24 2
2014-02-25protein level
3 24 2
2013-12-09protein level
3 23 2
2013-11-01protein level
3 23 2
2013-09-12protein level
3 23 2
2013-08-17protein level
3 23 2
2013-07-15protein level
3 16 0
2013-06-11protein level
3 16 0
2013-02-12protein level
3 5 0
2012-12-20protein level
3 5 0
2012-10-30protein level
3 5 0
2012-10-07protein level
3 5 0
2012-08-24protein level
3 0 0
2012-07-28protein level
3 0 0
2012-06-08protein level
3 9 0
2012-05-07protein level
3 11 0
2012-04-10protein level
3 11 0
2012-01-13protein level
3 9 0
2011-12-20protein level
3 9 0
2011-11-11protein level
3 9 0
2011-08-23protein level
3 9 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q6NYC1-1
0 14 0 46433.0106
NX_Q6NYC1-2
1 12 0 43082.5679
NX_Q6NYC1-3
0 14 0 47596.5689
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-8464037,EBI-723869 BRD4  
  .negative regulation of DNA damage checkpoint
.regulation of phosphorylation of RNA polymerase II C-terminal domain
.regulation of inflammatory response
  + 15 more...
.lysine-acetylated histone binding
.chromatin binding
.DNA binding
.p53 binding
.positive transcription elongation factor complex b
.cytoplasm
.chromosome
  + 4 more...
2 EBI-8464037,EBI-1383449 CDK9  
  .positive regulation of histone H2B ubiquitination
.positive regulation of mRNA 3'-UTR binding
.negative regulation of mRNA polyadenylation
  + 18 more...
.transcription regulatory region DNA binding
.snRNA binding
.RNA polymerase II carboxy-terminal domain kinase activity
  + 5 more...
.intracellular membrane-bounded organelle
.PML body
.membrane
  + 4 more...
3 EBI-8464037,EBI-632461 U2AF1  
  .mRNA 3'-end processing
.gene expression
.RNA splicing
  + 5 more...
.metal ion binding
.poly(A) RNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.nuclear speck
.Cajal body
  + 2 more...
4 EBI-8464037,EBI-715374 PRPF38A  
  .RNA splicing
.mRNA processing
.poly(A) RNA binding .precatalytic spliceosome
.nuclear membrane
.nucleus
5 EBI-8464037,EBI-741729 FRMD6  
  .cellular protein localization
.regulation of actin filament-based process
.apical constriction
.N/A .apical junction complex
.plasma membrane
.cytoskeleton
.cytoplasm
6 EBI-8464037,EBI-1052523 NAA50  
  .mitotic sister chromatid cohesion, centromeric
.histone H4 acetylation
.N-terminal protein amino acid acetylation
.peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
.H4 histone acetyltransferase activity
.peptide alpha-N-acetyltransferase activity
.extracellular exosome
.cytoplasm
7 EBI-8464037,EBI-746345 ZCCHC17  
  .activation of mitophagy in response to mitochondrial depolarization
.positive regulation of defense response to virus by host
.poly(A) RNA binding
.zinc ion binding
.intermediate filament cytoskeleton
.intracellular membrane-bounded organelle
.ribonucleoprotein complex
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites125
bladder66
blood89
bone97
bone marrow20
brain43
cervix41
connective tissue40
embryonic tissue18
esophagus49
eye57
heart22
intestine51
kidney61
liver53
lung86
lymph node44
mammary gland33
muscle75
ovary68
pancreas74
parathyroid97
pituitary gland60
placenta52
prostate68
salivary gland394
skin56
spleen37
stomach41
testis82
thymus12
thyroid42
umbilical cord72
uterus43
vascular58
Health State
TissuesTPM*
normal54
bladder carcinoma227
breast (mammary gland) tumor42
chondrosarcoma84
colorectal tumor8
esophageal tumor57
gastrointestinal tumor75
germ cell tumor45
glioma83
head and neck tumor59
kidney tumor14
leukemia42
liver tumor31
lung tumor58
non-neoplasia20
ovarian tumor65
pancreatic tumor57
primitive neuroectodermal tumor of the CNS55
prostate cancer19
retinoblastoma21
skin tumor63
soft tissue/muscle tissue tumor31
uterine tumor33
Developmental Stage
TissuesTPM*
adult62
blastocyst32
neonate96
fetus57
infant127
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue17.8
adrenal gland23.8
appendix19.4
bone marrow96.4
cerebral cortex9.6
colon14.4
duodenum17.1
esophagus17.4
gallbladder23.6
heart muscle19.1
kidney11.1
liver12.8
lung15.4
lymph node18.4
ovary18.5
pancreas10.9
placenta18.3
prostate15.9
salivary gland11.1
skin8.8
small intestine14.8
spleen19.2
stomach11.4
testis19.7
thyroid gland10.5
urinary bladder20.1
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusLow
kidneyHigh
lateral ventricleMedium
lungHigh
lymph nodeHigh
nasopharynxMedium
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleMedium
skeletal muscleHigh
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2Medium
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604914, gene) Jumonji domain-containing protein 6; JMJD6OMIM


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