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> Protein (NX_Q6NYC8)
Protein (NX_Q6NYC8)
Protein
Gene SymbolPPP1R18 to neXtProt (NX_Q6NYC8)
DescriptionPhostensin
Chromosome6
Location6p21.33 (30644166 ~ 30655672) to Ensembl
Sequene Features : Isoforms 4, Variants 21, PTMs 14 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .cytoskeleton
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 21 14
2014-09-19protein level
2 37 15
2014-05-27protein level
2 48 15
2014-02-25protein level
2 21 14
2013-12-09protein level
2 11 14
2013-11-01protein level
2 11 14
2013-09-12protein level
2 11 14
2013-08-17protein level
2 11 14
2013-07-15protein level
2 11 14
2013-06-11protein level
2 11 14
2013-02-12protein level
2 11 25
2012-12-20protein level
2 10 25
2012-10-30protein level
2 13 25
2012-10-07protein level
2 13 14
2012-08-24protein level
2 13 14
2012-07-28protein level
2 13 14
2012-06-08protein level
2 22 14
2012-05-07protein level
2 22 14
2012-04-10protein level
2 22 14
2012-01-13protein level
2 15 14
2011-12-20protein level
2 15 14
2011-11-11protein level
2 15 12
2011-08-23protein level
2 16 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q6NYC8-1
0 29 0 67901.3074
NX_Q6NYC8-2
3 18 0 42806.633
NX_Q6NYC8-3
3 15 0 39349.01
NX_Q6NYC8-4
0 6 0 17760.0618
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2557469,EBI-5661036 FSD2  
  .N/A .N/A .N/A
2 EBI-2557469,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
3 EBI-2557469,EBI-475646 NEFL  
  .response to corticosterone
.protein polymerization
.neuromuscular process controlling balance
  + 15 more...
.identical protein binding
.protein binding, bridging
.protein C-terminus binding
.structural constituent of cytoskeleton
.growth cone
.axon
.neurofilament
  + 2 more...
4 EBI-2557469,EBI-742756 KRT19  
  .cell differentiation involved in embryonic placenta development
.sarcomere organization
.response to estrogen
.viral process
.structural constituent of muscle
.structural constituent of cytoskeleton
.cell periphery
.extracellular exosome
.costamere
  + 5 more...
5 EBI-2557469,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
6 EBI-2557469,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
7 EBI-2557469,EBI-1055572 DES  
  .muscle filament sliding
.regulation of heart contraction
.cytoskeleton organization
.muscle contraction
.identical protein binding
.cytoskeletal protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.sarcolemma
.neuromuscular junction
  + 4 more...
8 EBI-2557469,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
9 EBI-2557469,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
10 EBI-2557469,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
11 EBI-2557469,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
12 EBI-2557469,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
13 EBI-2557469,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
14 EBI-2557469,EBI-2808286 CCDC57  
  .N/A .N/A .N/A
15 EBI-2557469,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
16 EBI-2557469,EBI-1105124 PDE4DIP  
  .cellular protein complex assembly .enzyme binding .myofibril
.centrosome
.Golgi apparatus
  + 2 more...
17 EBI-2557469,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
18 EBI-2557469,EBI-4397613 KCTD9  
  .protein homooligomerization .N/A .N/A
19 EBI-2557469,EBI-749955 TRIM69  
  .apoptotic process .ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.nuclear speck
.plasma membrane
.cytoplasm
.nucleus
20 EBI-2557469,EBI-742397 TEX11  
  .chiasma assembly
.negative regulation of apoptotic process
.fertilization
  + 6 more...
.N/A .central element
21 EBI-2557469,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
22 EBI-2557469,EBI-2799833 VPS52  
  .embryonic ectodermal digestive tract development
.protein transport
.ectodermal cell differentiation
.syntaxin binding .perinuclear region of cytoplasm
.endosome membrane
.Golgi apparatus
23 EBI-2557469,EBI-749265 CCDC155  
  .chromosome localization to nuclear envelope involved in homologous chromosome segregation
.oogenesis
.spermatogenesis
  + 2 more...
.N/A .integral component of membrane
.nuclear outer membrane
.lateral element
.chromosome, telomeric region
24 EBI-2557469,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
25 EBI-2557469,EBI-715381 SPDL1  
  .cell division
.protein localization to kinetochore
.spindle checkpoint
  + 4 more...
.kinetochore binding
.enzyme binding
.cytosol
.microtubule organizing center
.nucleus
  + 2 more...
26 EBI-2557469,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
27 EBI-2557469,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
28 EBI-2557469,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
29 EBI-2557469,EBI-744794 TSGA10  
  .cell projection assembly
.spermatogenesis
.N/A .neuron projection
.nuclear membrane
.motile cilium
.cytoplasm
30 EBI-2557469,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
31 EBI-2557469,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
32 EBI-2557469,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
blood139
bone111
bone marrow205
brain32
connective tissue73
ear62
embryonic tissue65
esophagus49
eye57
heart55
intestine17
kidney61
liver34
lung56
lymph180
lymph node245
mammary gland13
mouth30
muscle37
nerve64
ovary29
pancreas215
pharynx24
placenta45
prostate5
skin52
spleen93
stomach20
testis4
thymus62
thyroid21
tonsil235
trachea57
umbilical cord217
uterus73
vascular38
Health State
TissuesTPM*
normal50
breast (mammary gland) tumor10
chondrosarcoma156
esophageal tumor57
gastrointestinal tumor25
germ cell tumor60
glioma139
head and neck tumor14
kidney tumor58
leukemia169
liver tumor62
lung tumor77
lymphoma263
non-neoplasia41
ovarian tumor13
pancreatic tumor333
primitive neuroectodermal tumor of the CNS94
prostate cancer9
retinoblastoma64
skin tumor39
soft tissue/muscle tissue tumor87
uterine tumor66
Developmental Stage
TissuesTPM*
adult51
embryoid body114
blastocyst32
neonate96
fetus50
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue35.5
adrenal gland19.1
appendix77
bone marrow61
cerebral cortex12.2
colon18.9
duodenum15.1
esophagus20
gallbladder50.8
heart muscle14.6
kidney8.1
liver18.2
lung39.5
lymph node122.5
ovary28
pancreas5.5
placenta40.8
prostate14.1
salivary gland10.5
skin23.9
small intestine16.9
spleen77.1
stomach18.1
testis9.2
thyroid gland10.1
urinary bladder56.7
Tissues
TissuesExpression level
appendixMedium
bone marrowMedium
cerebral cortexLow
colonLow
endometrium 2Low
lungLow
lymph nodeHigh
spleenHigh
tonsilHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610990, gene) Kiaa1949 gene; KIAA1949OMIM


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