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> Protein (NX_Q6P158)
Protein (NX_Q6P158)
Protein
Gene SymbolDHX57 to neXtProt (NX_Q6P158)
DescriptionPutative ATP-dependent RNA helicase DHX57
Chromosome2
Location2p22.1 (39024871 ~ 39103075) to Ensembl
Sequene Features : Isoforms 3, Variants 158, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.RNA processing .metal ion binding
.poly(A) RNA binding
.ATP binding
.ATP-dependent RNA helicase activity
.mitochondrion
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 158 5
2014-09-19protein level
3 131 5
2014-05-27protein level
3 131 5
2014-02-25protein level
3 131 5
2013-12-09protein level
3 101 5
2013-11-01protein level
3 99 4
2013-09-12protein level
3 99 4
2013-08-17protein level
3 99 4
2013-07-15protein level
3 77 4
2013-06-11protein level
3 77 4
2013-02-12protein level
3 45 15
2012-12-20protein level
3 44 15
2012-10-30protein level
3 52 15
2012-10-07protein level
3 52 5
2012-08-24protein level
3 38 5
2012-07-28protein level
3 38 5
2012-06-08protein level
3 40 5
2012-05-07protein level
3 40 5
2012-04-10protein level
3 40 5
2012-01-13protein level
3 16 5
2011-12-20protein level
3 16 5
2011-11-11protein level
3 16 5
2011-08-23protein level
3 16 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q6P158-1
37 30 2 155506.3569
NX_Q6P158-2
2 30 1 73555.7425
NX_Q6P158-3
1 19 0 49476.246
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1051531,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
2 EBI-1051531,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
3 EBI-1051531,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
4 EBI-1051531,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
5 EBI-1051531,EBI-745934 CBX2  
  .development of primary sexual characteristics
.cellular protein metabolic process
.post-translational protein modification
  + 5 more...
.chromatin binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 3 more...
6 EBI-1051531,EBI-751409 ZNF473  
  .mRNA 3'-end processing
.gene expression
.histone mRNA metabolic process
  + 4 more...
.metal ion binding
.DNA binding
.Cajal body
.nucleoplasm
7 EBI-1051531,EBI-10185730 KRTAP9-4  
  .N/A .N/A .keratin filament
8 EBI-1051531,EBI-744115 CEP44  
  .N/A .N/A .midbody
.centrosome
.cytoplasm
.spindle pole
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
blood16
brain7
connective tissue13
embryonic tissue32
eye14
intestine34
kidney14
larynx42
liver29
lung26
lymph node22
mammary gland33
mouth15
nerve128
ovary49
pancreas23
pharynx24
pituitary gland60
placenta17
skin42
spleen18
stomach10
testis36
thyroid21
trachea38
umbilical cord145
uterus8
Health State
TissuesTPM*
normal19
adrenal tumor79
breast (mammary gland) tumor42
chondrosarcoma24
colorectal tumor53
germ cell tumor18
head and neck tumor29
kidney tumor14
leukemia10
liver tumor52
lung tumor9
ovarian tumor65
pancreatic tumor9
primitive neuroectodermal tumor of the CNS23
retinoblastoma43
skin tumor63
soft tissue/muscle tissue tumor15
Developmental Stage
TissuesTPM*
adult21
embryoid body14
blastocyst48
neonate64
fetus23
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.7
adrenal gland6.9
appendix6.6
bone marrow5.1
cerebral cortex7.8
colon5.6
duodenum3.7
esophagus5.1
gallbladder5.9
heart muscle4
kidney6.8
liver3
lung5.4
lymph node7.5
ovary8.9
pancreas2.5
placenta6.3
prostate6.4
salivary gland3.3
skin7.5
small intestine3.2
spleen6.3
stomach4.8
testis29.9
thyroid gland8.5
urinary bladder6.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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