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> Protein (NX_Q6P1J9)
Protein (NX_Q6P1J9)
Protein
Gene SymbolCDC73 to neXtProt (NX_Q6P1J9)
DescriptionParafibromin
Chromosome1
Location1q31.2 (193091147 ~ 193223031) to Ensembl
Sequene Features : Isoforms 1, Variants 99, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of G1/S transition of mitotic cell cycle
.cellular response to lipopolysaccharide
.negative regulation of epithelial cell proliferation
  + 17 more...
.RNA polymerase II core binding .Cdc73/Paf1 complex
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 99 5
2014-09-19protein level
1 81 5
2014-05-27protein level
1 81 5
2014-02-25protein level
1 80 5
2013-12-09protein level
1 77 5
2013-11-01protein level
1 75 4
2013-09-12protein level
1 75 4
2013-08-17protein level
1 75 4
2013-07-15protein level
1 58 2
2013-06-11protein level
1 58 2
2013-02-12protein level
1 23 4
2012-12-20protein level
1 23 4
2012-10-30protein level
1 24 4
2012-10-07protein level
1 24 4
2012-08-24protein level
1 24 4
2012-07-28protein level
1 23 4
2012-06-08protein level
1 17 4
2012-05-07protein level
1 17 4
2012-04-10protein level
1 17 4
2012-01-13protein level
1 17 4
2011-12-20protein level
1 17 4
2011-11-11protein level
1 17 4
2011-08-23protein level
1 17 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q6P1J9-1
28 0 0 60538.9056
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-930143,EBI-5661036 FSD2  
  .N/A .N/A .N/A
2 EBI-930143,EBI-533127 BCL9  
  .canonical Wnt signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
.skeletal muscle cell differentiation
  + 2 more...
.N/A .cis-Golgi network
.Golgi apparatus
.nucleoplasm
3 EBI-930143,EBI-3905054 ALAS1  
  .small molecule metabolic process
.cellular lipid metabolic process
.mitochondrion organization
  + 4 more...
.pyridoxal phosphate binding
.5-aminolevulinate synthase activity
.mitochondrial matrix
.mitochondrion
.cytoplasm
.nucleoplasm
4 EBI-930143,EBI-295301 POLR2A  
  .positive regulation of viral transcription
.somatic stem cell maintenance
.piRNA metabolic process
  + 13 more...
.metal ion binding
.poly(A) RNA binding
.ubiquitin protein ligase binding
  + 3 more...
.DNA-directed RNA polymerase II, core complex
.nucleoplasm
.nucleus
5 EBI-930143,EBI-491549 CTNNB1  
  .negative regulation of apoptotic signaling pathway
.positive regulation of DNA-templated transcription, initiation
.positive regulation of determination of dorsal identity
  + 126 more...
.euchromatin binding
.R-SMAD binding
.I-SMAD binding
  + 18 more...
.cell periphery
.beta-catenin-TCF7L2 complex
.extracellular exosome
  + 32 more...
6 EBI-930143,EBI-591370 KMT2A  
  .positive regulation of cellular response to drug
.regulation of histone H3-K9 acetylation
.histone H3-K4 trimethylation
  + 16 more...
.lysine-acetylated histone binding
.unmethylated CpG binding
.transcription regulatory region DNA binding
  + 8 more...
.MLL1 complex
.histone methyltransferase complex
.cytoplasm
  + 2 more...
7 EBI-930143,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
8 EBI-930143,EBI-717422 TFCP2  
  .regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.sequence-specific DNA binding
.protein C-terminus binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
9 EBI-930143,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
10 EBI-930143,EBI-1019583 CTR9  
  .positive regulation of histone H2B ubiquitination
.positive regulation of histone H3-K79 methylation
.negative regulation of mRNA polyadenylation
  + 15 more...
.RNA polymerase II core binding .transcriptionally active chromatin
.nuclear speck
.Cdc73/Paf1 complex
11 EBI-930143,EBI-749265 CCDC155  
  .chromosome localization to nuclear envelope involved in homologous chromosome segregation
.oogenesis
.spermatogenesis
  + 2 more...
.N/A .integral component of membrane
.nuclear outer membrane
.lateral element
.chromosome, telomeric region
12 EBI-930143,EBI-2607770 PAF1  
  .cellular response to lipopolysaccharide
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of myeloid cell differentiation
  + 13 more...
.chromatin binding
.RNA polymerase II core binding
.Cdc73/Paf1 complex
.membrane
.cytoplasm
13 EBI-930143,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
14 EBI-930143,EBI-932432 LEO1  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of myeloid cell differentiation
.histone H2B ubiquitination
  + 8 more...
.N/A .Cdc73/Paf1 complex
.nucleolus
.nucleoplasm
15 EBI-930143,EBI-1055239 RTF1  
  .histone H3-K4 trimethylation
.positive regulation of histone H3-K4 methylation
.positive regulation of transcription from RNA polymerase II promoter
  + 6 more...
.poly(A) RNA binding
.single-stranded DNA binding
.Cdc73/Paf1 complex
.nucleolus
16 EBI-930143,EBI-744794 TSGA10  
  .cell projection assembly
.spermatogenesis
.N/A .neuron projection
.nuclear membrane
.motile cilium
.cytoplasm
17 EBI-930143,EBI-4400866 VPS37B  
  .positive regulation of viral budding via host ESCRT complex
.positive regulation of viral release from host cell
.intracellular transport of virus
  + 7 more...
.calcium-dependent protein binding .extracellular exosome
.late endosome membrane
.midbody
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites25
bladder66
blood57
bone13
bone marrow102
brain14
connective tissue60
ear62
embryonic tissue65
esophagus49
eye28
heart22
intestine25
kidney23
liver29
lung32
lymph22
lymph node33
mammary gland99
mouth15
muscle47
nerve257
pancreas37
parathyroid48
pharynx24
placenta52
prostate100
skin42
spleen37
stomach52
testis34
thymus12
thyroid64
trachea38
uterus73
vascular38
Health State
TissuesTPM*
normal39
adrenal tumor79
bladder carcinoma170
breast (mammary gland) tumor96
chondrosarcoma12
colorectal tumor26
gastrointestinal tumor50
germ cell tumor37
head and neck tumor14
kidney tumor43
leukemia31
liver tumor52
lung tumor19
lymphoma13
non-neoplasia31
pancreatic tumor38
prostate cancer125
retinoblastoma64
skin tumor55
soft tissue/muscle tissue tumor95
uterine tumor55
Developmental Stage
TissuesTPM*
adult47
embryoid body57
blastocyst65
neonate96
fetus44
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.3
adrenal gland14.9
appendix14.8
bone marrow13.3
cerebral cortex10.6
colon12.3
duodenum9.5
esophagus17.4
gallbladder14.1
heart muscle13.4
kidney12.8
liver7.8
lung11.3
lymph node15
ovary15.9
pancreas4.4
placenta12.4
prostate18.5
salivary gland7.2
skin7.5
small intestine10.9
spleen11.2
stomach11.5
testis13.1
thyroid gland21.1
urinary bladder16.8
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 2High
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderHigh
hippocampusLow
kidneyMedium
lateral ventricleLow
liverLow
lungLow
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
rectumHigh
salivary glandMedium
seminal vesicleLow
skeletal muscleMedium
skin 2High
small intestineHigh
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#145000, phenotype) Hyperparathyroidism 1; HRPT1OMIM
2(#145001, phenotype) Hyperparathyroidism 2; HRPT2OMIM
3(*607393, gene) Cell division cycle protein 73, s. cerevisiae, homolog of; CDC73OMIM
4(#608266, phenotype) Parathyroid carcinomaOMIM


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