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> Protein (NX_Q6P2Q9)
Protein (NX_Q6P2Q9)
Protein
Gene SymbolPRPF8 to neXtProt (NX_Q6P2Q9)
DescriptionPre-mRNA-processing-splicing factor 8
Chromosome17
Location17p13.3 (1553923 ~ 1588176) to Ensembl
Sequene Features : Isoforms 1, Variants 192, PTMs 48 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.gene expression
.RNA splicing
.mRNA processing
  + 3 more...
.pre-mRNA intronic binding
.K63-linked polyubiquitin binding
.poly(A) RNA binding
  + 5 more...
.catalytic step 2 spliceosome
.nuclear speck
.membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 192 48
2014-09-19protein level
1 141 48
2014-05-27protein level
1 141 48
2014-02-25protein level
1 140 47
2013-12-09protein level
1 130 47
2013-11-01protein level
1 121 30
2013-09-12protein level
1 121 32
2013-08-17protein level
1 121 32
2013-07-15protein level
1 88 7
2013-06-11protein level
1 88 7
2013-02-12protein level
1 34 8
2012-12-20protein level
1 34 8
2012-10-30protein level
1 36 8
2012-10-07protein level
1 36 8
2012-08-24protein level
1 20 8
2012-07-28protein level
1 20 8
2012-06-08protein level
1 30 8
2012-05-07protein level
1 27 8
2012-04-10protein level
1 27 8
2012-01-13protein level
1 30 8
2011-12-20protein level
1 30 8
2011-11-11protein level
1 30 7
2011-08-23protein level
1 30 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q6P2Q9-1
116 0 0 273425.7829
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-538479,EBI-1050106 BCAS2  
  .gene expression
.RNA splicing
.mRNA splicing, via spliceosome
.RNA splicing, via transesterification reactions
.N/A .cell junction
.nucleolus
.spliceosomal complex
  + 2 more...
2 EBI-538479,EBI-750559 SLU7  
  .cellular response to heat
.intracellular protein transport
.mRNA splicing, via spliceosome
  + 3 more...
.pre-mRNA 3'-splice site binding
.zinc ion binding
.second spliceosomal transesterification activity
.catalytic step 2 spliceosome
.intracellular membrane-bounded organelle
.small nuclear ribonucleoprotein complex
  + 6 more...
3 EBI-538479,EBI-749111 SF3B2  
  .viral process
.gene expression
.RNA splicing
  + 2 more...
.poly(A) RNA binding .catalytic step 2 spliceosome
.U12-type spliceosomal complex
.spliceosomal complex
.nucleoplasm
4 EBI-538479,EBI-357897 EFTUD2  
  .gene expression
.RNA splicing
.mRNA processing
.mRNA splicing, via spliceosome
.poly(A) RNA binding
.GTP binding
.GTPase activity
.catalytic step 2 spliceosome
.nuclear speck
.membrane
  + 4 more...
5 EBI-538479,EBI-946095 PCBP1  
  .gene expression
.RNA splicing
.mRNA splicing, via spliceosome
.poly(A) RNA binding
.RNA binding
.single-stranded DNA binding
.extracellular exosome
.intracellular membrane-bounded organelle
.ribonucleoprotein complex
  + 3 more...
6 EBI-538479,EBI-348469 SF3B4  
  .positive regulation of mRNA splicing, via spliceosome
.gene expression
.RNA splicing
  + 3 more...
.poly(A) RNA binding
.nucleotide binding
.U12-type spliceosomal complex
.spliceosomal complex
.nucleoplasm
7 EBI-538479,EBI-746309 GPKOW  
  .N/A .nucleic acid binding .nucleoplasm
8 EBI-538479,EBI-538492 SNRNP40  
  .gene expression
.RNA splicing
.RNA processing
  + 2 more...
.poly(A) RNA binding .catalytic step 2 spliceosome
.cytoplasm
.small nucleolar ribonucleoprotein complex
  + 2 more...
9 EBI-538479,EBI-3920997 ZNF830  
  .intestinal epithelial structure maintenance
.cell division
.chromosome organization
  + 4 more...
.metal ion binding .nuclear speck
.cytoplasm
.nucleoplasm
10 EBI-538479,EBI-7705033 WDR83  
  .mRNA splicing, via spliceosome
.RNA splicing, via transesterification reactions
.N/A .catalytic step 2 spliceosome
.cytoplasm
.spliceosomal complex
11 EBI-538479,EBI-395746 PRPF19  
  .signal transduction involved in DNA damage checkpoint
.protein K63-linked ubiquitination
.positive regulation of astrocyte differentiation
  + 14 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin-ubiquitin ligase activity
.ligase activity
.catalytic step 2 spliceosome
.U2-type catalytic step 1 spliceosome
.site of double-strand break
  + 8 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland121
bladder33
blood179
bone279
bone marrow102
brain143
cervix412
connective tissue120
embryonic tissue319
esophagus99
eye344
heart100
intestine245
kidney185
larynx809
liver146
lung134
lymph248
lymph node345
mammary gland548
mouth513
muscle150
nerve450
ovary256
pancreas149
pharynx73
pituitary gland121
placenta166
prostate232
salivary gland98
skin223
spleen74
stomach324
testis96
thymus112
thyroid322
tonsil117
trachea96
umbilical cord726
uterus172
vascular58
Health State
TissuesTPM*
normal158
adrenal tumor158
breast (mammary gland) tumor687
cervical tumor463
chondrosarcoma253
colorectal tumor382
esophageal tumor115
gastrointestinal tumor168
germ cell tumor121
glioma205
head and neck tumor463
kidney tumor319
leukemia275
liver tumor197
lung tumor243
lymphoma249
non-neoplasia103
ovarian tumor249
pancreatic tumor161
primitive neuroectodermal tumor of the CNS173
prostate cancer211
retinoblastoma602
skin tumor279
soft tissue/muscle tissue tumor135
uterine tumor221
Developmental Stage
TissuesTPM*
adult274
embryoid body271
blastocyst439
neonate321
fetus98
infant127
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue45.8
adrenal gland61.1
appendix56.1
bone marrow89.3
cerebral cortex42.4
colon48.9
duodenum38
esophagus45.4
gallbladder43.5
heart muscle39
kidney38.1
liver28.7
lung63.2
lymph node71
ovary91.6
pancreas26.6
placenta51.5
prostate48.4
salivary gland40.5
skin66.9
small intestine43.2
spleen64.7
stomach45.9
testis67.8
thyroid gland63.1
urinary bladder46.6
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Low
epididymisHigh
esophagusMedium
fallopian tubeLow
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungHigh
lymph nodeLow
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleLow
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1Low
stomach 2High
testisMedium
thyroid glandMedium
tonsilLow
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#600059, phenotype) Retinitis pigmentosa 13; RP13OMIM
2(*607300, gene) Precursor mrna-processing factor 8, s. cerevisiae, homolog of; PRPF8OMIM


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