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> Protein (NX_Q6P597)
Protein (NX_Q6P597)
Protein
Gene SymbolKLC3 to neXtProt (NX_Q6P597)
DescriptionKinesin light chain 3
Chromosome19
Location19q13.32 (45836692 ~ 45854778) to Ensembl
Sequene Features : Isoforms 3, Variants 69, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.axon cargo transport .microtubule motor activity .neuron projection
.ciliary rootlet
.motile cilium
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 69 5
2014-09-19protein level
3 54 5
2014-05-27protein level
3 54 5
2014-02-25protein level
3 54 5
2013-12-09protein level
3 30 5
2013-11-01protein level
3 29 5
2013-09-12protein level
3 29 6
2013-08-17protein level
3 29 6
2013-07-15protein level
3 15 6
2013-06-11protein level
3 15 6
2013-02-12protein level
3 10 18
2012-12-20protein level
3 7 18
2012-10-30protein level
3 16 18
2012-10-07protein level
3 16 6
2012-08-24protein level
3 16 6
2012-07-28protein level
3 16 6
2012-06-08protein level
3 17 6
2012-05-07protein level
3 14 6
2012-04-10protein level
3 14 6
2012-01-13protein level
3 4 6
2011-12-20protein level
3 4 6
2011-11-11protein level
3 4 4
2011-08-23protein level
3 4 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q6P597-1
0 25 4 55330.4163
NX_Q6P597-2
1 24 4 55202.3581
NX_Q6P597-3
1 24 4 56758.0562
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1643885,EBI-10171799 CCDC64B  
  .N/A .N/A .N/A
2 EBI-1643885,EBI-715849 NDC80  
  .attachment of mitotic spindle microtubules to kinetochore
.cell division
.attachment of spindle microtubules to kinetochore
  + 7 more...
.identical protein binding
.structural constituent of cytoskeleton
.Ndc80 complex
.membrane
.cytosol
  + 5 more...
3 EBI-1643885,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
4 EBI-1643885,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
5 EBI-1643885,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
6 EBI-1643885,EBI-347462 QARS  
  .gene expression
.brain development
.glutaminyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.glutamine-tRNA ligase activity
.cytosol
.mitochondrial matrix
.cytoplasm
7 EBI-1643885,EBI-741406 CCNH  
  .positive regulation of viral transcription
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of gene expression, epigenetic
  + 20 more...
.cyclin-dependent protein serine/threonine kinase regulator activity
.kinase activity
.TFIIK complex
.cyclin-dependent protein kinase activating kinase holoenzyme complex
.holo TFIIH complex
  + 2 more...
8 EBI-1643885,EBI-10244848 SNAP47  
  .long-term synaptic potentiation
.synaptic vesicle fusion to presynaptic membrane
.synaptic vesicle priming
.syntaxin binding
.SNAP receptor activity
.perinuclear region of cytoplasm
.neuronal cell body
.SNARE complex
  + 3 more...
9 EBI-1643885,EBI-1105124 PDE4DIP  
  .cellular protein complex assembly .enzyme binding .myofibril
.centrosome
.Golgi apparatus
  + 2 more...
10 EBI-1643885,EBI-10250303 CENPP  
  .CENP-A containing nucleosome assembly
.small GTPase mediated signal transduction
.nucleosome assembly
.mitotic cell cycle
.N/A .cytosol
.nucleoplasm
.chromosome, centromeric region
11 EBI-1643885,EBI-10257016 ZNF572  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
12 EBI-1643885,EBI-740376 DTX2  
  .protein ubiquitination
.Notch signaling pathway
.ligase activity
.zinc ion binding
.nuclear membrane
.cytoplasm
.nucleoplasm
13 EBI-1643885,EBI-8638439 CCDC36  
  .positive regulation of defense response to virus by host .N/A .N/A
14 EBI-1643885,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
15 EBI-1643885,EBI-2799833 VPS52  
  .embryonic ectodermal digestive tract development
.protein transport
.ectodermal cell differentiation
.syntaxin binding .perinuclear region of cytoplasm
.endosome membrane
.Golgi apparatus
16 EBI-1643885,EBI-2892592 BBS5  
  .response to stimulus
.intracellular transport
.motile cilium assembly
  + 6 more...
.phosphatidylinositol-3-phosphate binding
.RNA polymerase II repressing transcription factor binding
.ciliary membrane
.ciliary basal body
.BBSome
  + 2 more...
17 EBI-1643885,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
18 EBI-1643885,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
19 EBI-1643885,EBI-742638 TSNAX  
  .RNA phosphodiester bond hydrolysis, endonucleolytic
.cell differentiation
.protein transport
  + 3 more...
.metal ion binding
.poly(A) RNA binding
.sequence-specific DNA binding
  + 4 more...
.perinuclear region of cytoplasm
.cytosol
.Golgi apparatus
  + 2 more...
20 EBI-1643885,EBI-749118 WAC  
  .histone H2B conserved C-terminal lysine ubiquitination
.positive regulation of transcription, DNA-templated
.G1 DNA damage checkpoint
  + 5 more...
.chromatin binding
.RNA polymerase II core binding
.nuclear speck
.spliceosomal complex
.nucleoplasm
.nucleus
21 EBI-1643885,EBI-10182361 MBIP  
  .histone H3 acetylation
.chromatin organization
.inactivation of MAPK activity involved in osmosensory signaling pathway
.identical protein binding
.protein kinase inhibitor activity
.cytoplasm
.nucleolus
.Ada2/Gcn5/Ada3 transcription activator complex
.nucleus
22 EBI-1643885,EBI-747481 IMP3  
  .rRNA processing .poly(A) RNA binding
.snoRNA binding
.Mpp10 complex
.small-subunit processome
.nucleolus
.nucleus
23 EBI-1643885,EBI-742038 ABI3  
  .regulation of cell migration
.movement of cell or subcellular component
.N/A .lamellipodium
.membrane
.cytoplasm
.intracellular
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
embryonic tissue4
kidney9
liver4
ovary9
placenta10
prostate5
uterus4
Health State
TissuesTPM*
normal3
adrenal tumor79
germ cell tumor7
kidney tumor29
liver tumor10
ovarian tumor13
Developmental Stage
TissuesTPM*
adult3
fetus5
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
esophagus7.7
kidney1.1
salivary gland4.2
skin38.4
testis2.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601334, gene) Kinesin light chain 3; KLC3OMIM


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