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> Protein (NX_Q6Q0C0)
Protein (NX_Q6Q0C0)
Protein
Gene SymbolTRAF7 to neXtProt (NX_Q6Q0C0)
DescriptionE3 ubiquitin-protein ligase TRAF7
Chromosome16
Location16p13.3 (2205699 ~ 2228130) to Ensembl
Sequene Features : Isoforms 2, Variants 91, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of apoptotic signaling pathway
.cellular response to interleukin-6
.positive regulation of MAPK cascade
  + 7 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.cytoplasmic membrane-bounded vesicle
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 91 4
2014-09-19protein level
2 73 4
2014-05-27protein level
2 73 4
2014-02-25protein level
2 73 4
2013-12-09protein level
2 61 4
2013-11-01protein level
2 57 2
2013-09-12protein level
2 57 2
2013-08-17protein level
2 57 2
2013-07-15protein level
2 23 2
2013-06-11protein level
2 23 2
2013-02-12protein level
2 9 6
2012-12-20protein level
2 9 6
2012-10-30protein level
2 10 6
2012-10-07protein level
2 10 3
2012-08-24protein level
2 9 3
2012-07-28protein level
2 9 3
2012-06-08protein level
2 9 3
2012-05-07protein level
2 4 3
2012-04-10protein level
2 4 3
2012-01-13protein level
2 3 3
2011-12-20protein level
2 3 3
2011-11-11protein level
2 3 3
2011-08-23protein level
2 3 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q6Q0C0-1
5 32 0 74560.69
NX_Q6Q0C0-2
1 32 0 66497.9415
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-307556,EBI-307281 MAP3K3  
  .positive regulation of p38MAPK cascade
.protein autophosphorylation
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 5 more...
.metal ion binding
.ATP binding
.MAP kinase kinase kinase activity
  + 2 more...
.cytosol
.intracellular
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites125
bladder33
blood49
bone181
bone marrow102
brain49
cervix20
connective tissue46
embryonic tissue108
esophagus49
eye90
heart33
intestine90
kidney33
liver38
lung134
lymph902
lymph node66
mammary gland85
muscle18
ovary137
pancreas79
pharynx49
placenta28
prostate110
salivary gland98
skin75
spleen37
stomach62
testis32
thymus12
thyroid85
uterus64
Health State
TissuesTPM*
normal39
bladder carcinoma56
breast (mammary gland) tumor139
cervical tumor28
chondrosarcoma265
colorectal tumor115
esophageal tumor57
gastrointestinal tumor92
germ cell tumor41
glioma177
head and neck tumor59
kidney tumor43
leukemia21
liver tumor72
lung tumor243
lymphoma554
non-neoplasia10
ovarian tumor170
pancreatic tumor76
primitive neuroectodermal tumor of the CNS133
prostate cancer163
retinoblastoma107
skin tumor79
soft tissue/muscle tissue tumor47
uterine tumor77
Developmental Stage
TissuesTPM*
adult69
embryoid body157
blastocyst81
fetus35
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue17.5
adrenal gland14.1
appendix25.6
bone marrow20.3
cerebral cortex12.7
colon25.6
duodenum33.5
esophagus33.5
gallbladder22.5
heart muscle10.7
kidney18.2
liver10.3
lung20.8
lymph node22.5
ovary11.9
pancreas12.1
placenta20.2
prostate15.1
salivary gland18.2
skin26.5
small intestine29.2
spleen24.3
stomach28.8
testis15.4
thyroid gland21
urinary bladder25
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
breastLow
bronchusMedium
cerebellumLow
cerebral cortexMedium
cervix, uterineLow
colonHigh
duodenumHigh
esophagusMedium
fallopian tubeLow
gallbladderLow
heart muscleMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungLow
oral mucosaHigh
rectumHigh
salivary glandLow
skeletal muscleHigh
skin 1Medium
skin 2Low
small intestineMedium
soft tissue 2Medium
stomach 1Low
stomach 2High
testisMedium
thyroid glandLow
tonsilLow
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606692, gene) Tnf receptor-associated factor 7; TRAF7OMIM


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