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> Protein (NX_Q6QNY1)
Protein (NX_Q6QNY1)
Protein
Gene SymbolBLOC1S2 to neXtProt (NX_Q6QNY1)
DescriptionBiogenesis of lysosome-related organelles complex 1 subunit 2
Chromosome10
Location10q24.31 (102033713 ~ 102046469) to Ensembl
Sequene Features : Isoforms 2, Variants 16, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.mitochondrial outer membrane permeabilization
.platelet dense granule organization
.anterograde synaptic vesicle transport
  + 8 more...
.gamma-tubulin binding
.protein C-terminus binding
.recycling endosome
.BLOC-1 complex
.centrosome
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 16 1
2014-09-19protein level
2 10 1
2014-05-27protein level
2 10 1
2014-02-25protein level
2 10 1
2013-12-09protein level
2 10 1
2013-11-01protein level
2 10 1
2013-09-12protein level
2 10 0
2013-08-17protein level
2 10 0
2013-07-15protein level
2 8 0
2013-06-11protein level
2 8 0
2013-02-12protein level
2 4 1
2012-12-20protein level
2 4 1
2012-10-30protein level
2 4 1
2012-10-07protein level
2 4 1
2012-08-24protein level
2 2 1
2012-07-28protein level
2 2 1
2012-06-08protein level
2 2 1
2012-05-07protein level
2 2 1
2012-04-10protein level
2 2 1
2012-01-13protein level
2 4 1
2011-12-20protein level
2 4 1
2011-11-11protein level
2 4 1
2011-08-23protein level
2 4 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q6QNY1-1
3 3 0 15951.046
NX_Q6QNY1-2
0 3 0 11481.9985
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-465872,EBI-296723 SNAPIN  
  .positive regulation of late endosome to lysosome transport
.autophagic vacuole maturation
.terminal button organization
  + 14 more...
.SNARE binding .perinuclear region of cytoplasm
.synapse
.BLOC-1 complex
  + 9 more...
2 EBI-465872,EBI-348630 BLOC1S1  
  .activation of mitophagy in response to mitochondrial depolarization
.membrane organization
.platelet dense granule organization
  + 7 more...
.N/A .extracellular exosome
.BLOC-1 complex
.cytosol
  + 4 more...
3 EBI-465872,EBI-465930 BLOC1S3  
  .membrane organization
.platelet dense granule organization
.anterograde synaptic vesicle transport
  + 12 more...
.N/A .BLOC-1 complex
.transport vesicle
.cytosol
4 EBI-465872,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
5 EBI-465872,EBI-465861 BLOC1S5  
  .positive regulation of pigment cell differentiation
.anterograde synaptic vesicle transport
.endosome to melanosome transport
  + 5 more...
.N/A .BLOC-1 complex
.transport vesicle
6 EBI-465872,EBI-465804 DTNBP1  
  .membrane organization
.regulation of dopamine receptor signaling pathway
.platelet dense granule organization
  + 11 more...
.N/A .postsynaptic membrane
.dendritic spine
.neuron projection
  + 14 more...
7 EBI-465872,EBI-725672 IFT57  
  .left/right pattern formation
.negative regulation of epithelial cell proliferation
.regulation of apoptotic process
  + 10 more...
.DNA binding .ciliary tip
.primary cilium
.dendrite terminus
  + 6 more...
8 EBI-465872,EBI-465781 BLOC1S6  
  .membrane fusion
.membrane organization
.positive regulation of pigment cell differentiation
  + 12 more...
.actin filament binding
.protein homodimerization activity
.identical protein binding
.syntaxin binding
.BLOC-1 complex
.transport vesicle
.extrinsic component of membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder33
blood24
bone97
bone marrow20
brain56
cervix41
connective tissue33
ear124
embryonic tissue51
eye47
intestine21
kidney33
liver14
lung32
lymph node100
mammary gland46
mouth15
muscle9
ovary39
pancreas84
parathyroid97
pharynx73
pituitary gland121
placenta24
prostate26
salivary gland98
skin61
spleen18
stomach83
testis43
thymus12
thyroid42
uterus43
vascular19
Health State
TissuesTPM*
normal38
bladder carcinoma56
breast (mammary gland) tumor32
cervical tumor57
chondrosarcoma48
colorectal tumor26
gastrointestinal tumor59
germ cell tumor26
glioma111
head and neck tumor22
kidney tumor14
leukemia52
lung tumor19
lymphoma13
non-neoplasia62
ovarian tumor52
pancreatic tumor38
primitive neuroectodermal tumor of the CNS7
prostate cancer48
retinoblastoma43
skin tumor47
soft tissue/muscle tissue tumor31
uterine tumor33
Developmental Stage
TissuesTPM*
adult44
embryoid body57
fetus21
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue21
adrenal gland38.8
appendix40.7
bone marrow66.4
cerebral cortex57.8
colon29.5
duodenum26.4
esophagus42.8
gallbladder28.7
heart muscle19.8
kidney32.4
liver22.7
lung30.1
lymph node64.4
ovary20.4
pancreas15.1
placenta24.8
prostate27.1
salivary gland19
skin32.5
small intestine22.3
spleen43.8
stomach27.5
testis26.7
thyroid gland31.1
urinary bladder38.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609768, gene) Biogenesis of lysosome-related organelles complex 1, subunit 2; BLOC1S2OMIM


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