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> Protein (NX_Q6RW13)
Protein (NX_Q6RW13)
Protein
Gene SymbolAGTRAP to neXtProt (NX_Q6RW13)
DescriptionType-1 angiotensin II receptor-associated protein
Chromosome1
Location1p36.22 (11796141 ~ 11814859) to Ensembl
Sequene Features : Isoforms 5, Variants 36, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of blood pressure
.response to hypoxia
.angiotensin type II receptor activity .intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
.integral component of membrane
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 36 1
2014-09-19protein level
5 31 1
2014-05-27protein level
5 27 1
2014-02-25protein level
5 27 1
2013-12-09protein level
5 20 1
2013-11-01protein level
5 19 1
2013-09-12protein level
5 19 1
2013-08-17protein level
5 19 1
2013-07-15protein level
5 18 1
2013-06-11protein level
5 18 1
2013-02-12protein level
5 12 0
2012-12-20protein level
5 11 0
2012-10-30protein level
5 10 0
2012-10-07protein level
5 10 0
2012-08-24protein level
5 9 0
2012-07-28protein level
5 9 0
2012-06-08protein level
5 11 0
2012-05-07protein level
5 11 0
2012-04-10protein level
5 11 0
2012-01-13protein level
5 3 0
2011-12-20protein level
5 3 0
2011-11-11protein level
5 3 0
2011-08-23protein level
5 3 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q6RW13-1
1 6 0 17407.883
NX_Q6RW13-2
1 6 0 16658.478
NX_Q6RW13-3
0 10 0 16037.5944
NX_Q6RW13-4
0 8 0 11940.3627
NX_Q6RW13-5
0 11 0 16955.0357
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-741181,EBI-751566 PDHX  
  .small molecule metabolic process
.cellular metabolic process
.regulation of acetyl-CoA biosynthetic process from pyruvate
.pyruvate metabolic process
.transferase activity, transferring acyl groups .mitochondrial matrix
2 EBI-741181,EBI-10186198 SSX5  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.nucleic acid binding .nucleus
3 EBI-741181,EBI-2513774 FARS2  
  .gene expression
.tRNA processing
.phenylalanyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.phenylalanine-tRNA ligase activity
.magnesium ion binding
.tRNA binding
.mitochondrial matrix
.mitochondrion
4 EBI-741181,EBI-4314390 CD160  
  .defense response to Gram-negative bacterium
.regulation of immune response
.cell proliferation
  + 2 more...
.MHC class I receptor activity
.receptor binding
.receptor activity
.anchored component of plasma membrane
.plasma membrane
5 EBI-741181,EBI-711828 CAPNS1  
  .extracellular matrix organization
.extracellular matrix disassembly
.positive regulation of cell proliferation
.proteolysis
.calcium ion binding
.calcium-dependent cysteine-type endopeptidase activity
.extracellular exosome
.membrane
.plasma membrane
  + 2 more...
6 EBI-741181,EBI-389432 HMGB1  
  .negative regulation of apoptotic cell clearance
.DNA ligation involved in DNA repair
.positive chemotaxis
  + 23 more...
.repressing transcription factor binding
.RAGE receptor binding
.poly(A) RNA binding
  + 9 more...
.cell surface
.nucleoplasm
.nucleus
  + 3 more...
7 EBI-741181,EBI-389728 NFYB  
  .positive regulation of transcription, DNA-templated
.small molecule metabolic process
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.repressing transcription factor binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 2 more...
.protein-DNA complex
.CCAAT-binding factor complex
.nucleoplasm
.nucleus
8 EBI-741181,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
9 EBI-741181,EBI-356933 HSPA4  
  .chaperone-mediated protein complex assembly
.protein import into mitochondrial outer membrane
.response to unfolded protein
.ATP binding .extracellular exosome
.cytosol
.mitochondrion
10 EBI-741181,EBI-10207709 GDNF  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of branching involved in ureteric bud morphogenesis
.positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
  + 28 more...
.protein homodimerization activity
.receptor binding
.extracellular region
11 EBI-741181,EBI-742898 PTPN9  
  .peptidyl-tyrosine dephosphorylation
.protein dephosphorylation
.non-membrane spanning protein tyrosine phosphatase activity
.protein tyrosine phosphatase activity
.cytoplasm
12 EBI-741181,EBI-3909030 HARS2  
  .gene expression
.histidyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.translation
.poly(A) RNA binding
.ATP binding
.histidine-tRNA ligase activity
.mitochondrial matrix
.mitochondrion
13 EBI-741181,EBI-638194 ARFIP2  
  .regulation of Arp2/3 complex-mediated actin nucleation
.ruffle organization
.actin cytoskeleton organization
  + 3 more...
.phosphatidylinositol-4-phosphate binding
.Rac GTPase binding
.GTP-dependent protein binding
.GTP binding
.trans-Golgi network membrane
.cell cortex
.plasma membrane
  + 2 more...
14 EBI-741181,EBI-1210304 ALDH18A1  
  .L-proline biosynthetic process
.small molecule metabolic process
.cellular nitrogen compound metabolic process
  + 5 more...
.NADP binding
.poly(A) RNA binding
.ATP binding
  + 2 more...
.mitochondrial inner membrane
.mitochondrion
.cytoplasm
15 EBI-741181,EBI-720116 GABARAPL2  
  .negative regulation of proteasomal protein catabolic process
.membrane fusion
.nucleophagy
  + 7 more...
.ATPase binding
.GABA receptor binding
.beta-tubulin binding
  + 2 more...
.cytoplasmic vesicle
.extrinsic component of membrane
.cytosol
  + 7 more...
16 EBI-741181,EBI-487083 TUBA1B  
  .cellular response to interleukin-4
.cell division
.protein polymerization
  + 6 more...
.ubiquitin protein ligase binding
.GTP binding
.structural constituent of cytoskeleton
  + 3 more...
.extracellular exosome
.cytoplasmic microtubule
.microtubule
17 EBI-741181,EBI-1049924 TFAM  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.mitochondrial respiratory chain complex assembly
  + 8 more...
.mitochondrial light strand promoter sense binding
.poly(A) RNA binding
.DNA binding, bending
  + 4 more...
.mitochondrial nucleoid
.cytosol
.mitochondrial matrix
  + 2 more...
18 EBI-741181,EBI-9304251 GAD2  
  .response to drug
.neurotransmitter biosynthetic process
.neurotransmitter secretion
  + 2 more...
.pyridoxal phosphate binding
.glutamate binding
.glutamate decarboxylase activity
.clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
.perinuclear region of cytoplasm
.presynaptic membrane
  + 7 more...
19 EBI-741181,EBI-357956 GTF3C1  
  .tRNA transcription from RNA polymerase III promoter
.5S class rRNA transcription from RNA polymerase III type 1 promoter
.gene expression
  + 4 more...
.DNA binding .ribonucleoprotein complex
.membrane
.nucleolus
  + 3 more...
20 EBI-741181,EBI-2822329 SNX1  
  .lamellipodium morphogenesis
.positive regulation of protein catabolic process
.retrograde transport, endosome to Golgi
  + 4 more...
.leptin receptor binding
.transferrin receptor binding
.identical protein binding
  + 3 more...
.protein complex
.intracellular membrane-bounded organelle
.early endosome membrane
  + 8 more...
21 EBI-741181,EBI-10234819 FASTKD3  
  .cellular respiration .poly(A) RNA binding
.protein kinase activity
.mitochondrion
22 EBI-741181,EBI-3919611 NKG7  
  .N/A .N/A .integral component of plasma membrane
23 EBI-741181,EBI-10238936 SYT16  
  .synaptic vesicle exocytosis
.vesicle fusion
.clathrin binding
.syntaxin binding
.phospholipid binding
.calcium ion binding
.plasma membrane
24 EBI-741181,EBI-521451 ECM29  
  .ER-associated ubiquitin-dependent protein catabolic process .N/A .endocytic vesicle
.ER to Golgi transport vesicle
.cytoplasmic membrane-bounded vesicle
  + 9 more...
25 EBI-741181,EBI-5454865 MRM1  
  .RNA processing
.rRNA processing
.poly(A) RNA binding
.RNA methyltransferase activity
.mitochondrion
26 EBI-741181,EBI-2686288 FAM114A1  
  .N/A .N/A .cytoplasm
27 EBI-741181,EBI-1805738 HSCB  
  .protein oligomerization
.iron-sulfur cluster assembly
.protein folding
.metal ion binding .plasma membrane
.centrosome
.mitochondrion
.cytoplasm
28 EBI-741181,EBI-742137 FAM160A2  
  .early endosome to late endosome transport
.protein transport
.endosome to lysosome transport
  + 2 more...
.N/A .FHF complex
29 EBI-741181,EBI-5459844 DDX55  
  .RNA secondary structure unwinding .poly(A) RNA binding
.ATP binding
.ATP-dependent RNA helicase activity
.membrane
.cytoplasm
.nucleolus
30 EBI-741181,EBI-745535 ADCK3  
  .phosphorylation
.ubiquinone biosynthetic process
.ADP binding
.kinase activity
.ATP binding
.integral component of membrane
.mitochondrion
31 EBI-741181,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
32 EBI-741181,EBI-743099 FATE1  
  .N/A .N/A .integral component of membrane
.endoplasmic reticulum
33 EBI-741181,EBI-702328 TBRG4  
  .cellular respiration
.positive regulation of cell proliferation
.cell cycle arrest
.poly(A) RNA binding
.protein kinase activity
.mitochondrion
34 EBI-741181,EBI-750153 MIEF2  
  .positive regulation of protein targeting to membrane
.positive regulation of mitochondrial fission
.positive regulation of protein homooligomerization
.mitochondrion organization
.N/A .integral component of membrane
.mitochondrial outer membrane
.mitochondrion
35 EBI-741181,EBI-2876502 ACSF2  
  .fatty acid metabolic process .ligase activity
.ATP binding
.mitochondrion
36 EBI-741181,EBI-10284754 BPIFA2  
  .defense response to bacterium .lipopolysaccharide binding .extracellular exosome
.extracellular region
37 EBI-741181,EBI-7825321 MTERF3  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.transcription regulatory region DNA binding
.double-stranded DNA binding
.mitochondrion
38 EBI-741181,EBI-932162 TPD52L3  
  .N/A .N/A .N/A
39 EBI-741181,EBI-2806908 RMDN2  
  .N/A .N/A .integral component of membrane
.microtubule
.mitochondrion
  + 2 more...
40 EBI-741181,EBI-5462748 TCEANC2  
  .transcription, DNA-templated .DNA binding .nucleus
41 EBI-741181,EBI-10292326 MCEE  
  .L-methylmalonyl-CoA metabolic process
.small molecule metabolic process
.cellular lipid metabolic process
  + 2 more...
.metal ion binding
.methylmalonyl-CoA epimerase activity
.mitochondrial matrix
42 EBI-741181,EBI-743184 GAD1  
  .response to drug
.neurotransmitter biosynthetic process
.protein-pyridoxal-5-phosphate linkage
  + 5 more...
.pyridoxal phosphate binding
.glutamate binding
.glutamate decarboxylase activity
.clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
.vesicle membrane
.plasma membrane
.intracellular
43 EBI-741181,EBI-10294329 HIST1H4G  
  .N/A .DNA binding .nucleus
.nucleosome
44 EBI-741181,EBI-2932492 TXN2  
  .oxidation-reduction process
.response to axon injury
.cell redox homeostasis
  + 12 more...
.peptide-methionine (R)-S-oxide reductase activity
.oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
.protein disulfide oxidoreductase activity
.peptide-methionine (S)-S-oxide reductase activity
.neuronal cell body
.dendrite
.mitochondrial matrix
  + 2 more...
45 EBI-741181,EBI-10295431 SSX3  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.nucleic acid binding .nucleus
46 EBI-741181,EBI-2849569 ZFYVE21  
  .N/A .metal ion binding .cytoplasmic membrane-bounded vesicle
.focal adhesion
.endosome
47 EBI-741181,EBI-2568609 FAM64A  
  .cell division
.mitotic nuclear division
.N/A .cytoplasm
.nucleolus
.nucleus
48 EBI-741181,EBI-2510241 DDA1  
  .N/A .N/A .N/A
49 EBI-741181,EBI-1047335 ISCU  
  .protein maturation by iron-sulfur cluster transfer
.[2Fe-2S] cluster assembly
.small molecule metabolic process
  + 3 more...
.4 iron, 4 sulfur cluster binding
.2 iron, 2 sulfur cluster binding
.iron-sulfur transferase activity
  + 3 more...
.cytosol
.mitochondrial matrix
.mitochondrion
  + 2 more...
50 EBI-741181,EBI-714881 SENP2  
  .regulation of G1/S transition of mitotic cell cycle
.spongiotrophoblast layer development
.labyrinthine layer development
  + 21 more...
.SUMO-specific protease activity .nuclear membrane
.cytoplasmic vesicle
.PML body
  + 2 more...
51 EBI-741181,EBI-740987 MIEF1  
  .positive regulation of protein targeting to membrane
.positive regulation of mitochondrial fission
.mitochondrial fission
.ADP binding
.identical protein binding
.GDP binding
.integral component of membrane
.mitochondrial outer membrane
.mitochondrion
52 EBI-741181,EBI-742688 SPG21  
  .antigen receptor-mediated signaling pathway .CD4 receptor binding .trans-Golgi network transport vesicle
.endosome membrane
.cytosol
  + 3 more...
53 EBI-741181,EBI-713677 CRCT1  
  .N/A .N/A .N/A
54 EBI-741181,EBI-10321956 MUTYH  
  .depurination
.mismatch repair
.base-excision repair, AP site formation
  + 2 more...
.4 iron, 4 sulfur cluster binding
.metal ion binding
.MutSalpha complex binding
.hydrolase activity, acting on glycosyl bonds
.mitochondrion
.nucleoplasm
.nucleus
55 EBI-741181,EBI-749241 PITPNC1  
  .phospholipid transport
.signal transduction
.phosphatidylinositol transporter activity
.lipid binding
.cytoplasm
.nucleoplasm
56 EBI-741181,EBI-4402391 PCTP  
  .phospholipid transport
.cholesterol metabolic process
.lipid transport
.phosphatidylcholine binding
.phosphatidylcholine transporter activity
.cytosol
57 EBI-741181,EBI-10323810 NDRG4  
  .positive regulation of ERK1 and ERK2 cascade
.cardiac muscle cell proliferation
.negative regulation of smooth muscle cell proliferation
  + 9 more...
.N/A .basolateral plasma membrane
.cytosol
.endoplasmic reticulum membrane
  + 2 more...
58 EBI-741181,EBI-725252 NFU1  
  .iron-sulfur cluster assembly .4 iron, 4 sulfur cluster binding
.iron ion binding
.cytosol
.mitochondrion
.cytoplasm
  + 2 more...
59 EBI-741181,EBI-2371151 AP3M1  
  .anterograde synaptic vesicle transport
.anterograde axon cargo transport
.protein targeting to lysosome
.Rab GTPase binding .cytoplasmic vesicle membrane
.clathrin adaptor complex
.Golgi apparatus
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites100
blood81
bone83
bone marrow61
brain19
cervix123
connective tissue33
embryonic tissue28
esophagus99
eye52
heart33
intestine51
kidney28
liver24
lung104
mammary gland33
muscle18
ovary39
pancreas51
placenta21
prostate68
salivary gland197
skin113
spleen18
stomach62
testis20
thyroid64
uterus77
vascular19
Health State
TissuesTPM*
normal34
breast (mammary gland) tumor32
cervical tumor57
chondrosarcoma72
colorectal tumor17
esophageal tumor115
gastrointestinal tumor101
germ cell tumor7
glioma102
head and neck tumor52
kidney tumor29
leukemia42
liver tumor20
lung tumor48
non-neoplasia10
ovarian tumor39
pancreatic tumor38
primitive neuroectodermal tumor of the CNS70
prostate cancer57
retinoblastoma43
skin tumor111
soft tissue/muscle tissue tumor7
uterine tumor133
Developmental Stage
TissuesTPM*
adult55
embryoid body28
blastocyst48
fetus28
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue23.7
adrenal gland13.9
appendix32.6
bone marrow83
cerebral cortex7.5
colon15.3
duodenum10
esophagus20.1
gallbladder28.1
heart muscle20.2
kidney36.7
liver7.1
lung35.1
lymph node25.6
ovary15.1
pancreas19.7
placenta22.8
prostate61.1
salivary gland19
skin14.2
small intestine10.2
spleen32.6
stomach17.4
testis18.5
thyroid gland27.6
urinary bladder30.2
Tissues
TissuesExpression level
adrenal glandLow
appendixLow
bone marrowMedium
breastHigh
bronchusLow
cerebral cortexLow
colonLow
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderLow
kidneyHigh
lungLow
nasopharynxLow
oral mucosaLow
pancreasHigh
parathyroid glandLow
placentaLow
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleHigh
skin 1Medium
skin 2Low
spleenMedium
stomach 1Low
stomach 2High
testisHigh
thyroid glandMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608729, gene) Angiotensin ii receptor-associated protein; AGTRAPOMIM


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