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> Protein (NX_Q6S5L8)
Protein (NX_Q6S5L8)
Protein
Gene SymbolSHC4 to neXtProt (NX_Q6S5L8)
DescriptionSHC-transforming protein 4
Chromosome15
Location15q21.1 (49115932 ~ 49255641) to Ensembl
Sequene Features : Isoforms 2, Variants 87, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.stem cell differentiation
.intracellular signal transduction
.regulation of gene expression
  + 3 more...
.receptor tyrosine kinase binding
.protein kinase binding
.postsynaptic membrane
.cell junction
.plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 87 1
2014-09-19protein level
2 72 1
2014-05-27protein level
2 71 1
2014-02-25protein level
2 71 1
2013-12-09protein level
2 51 1
2013-11-01protein level
2 49 1
2013-09-12protein level
2 49 1
2013-08-17protein level
2 49 1
2013-07-15protein level
2 41 1
2013-06-11protein level
2 41 1
2013-02-12protein level
2 20 2
2012-12-20protein level
2 20 2
2012-10-30protein level
2 24 2
2012-10-07protein level
2 24 1
2012-08-24protein level
2 19 1
2012-07-28protein level
2 19 1
2012-06-08protein level
2 26 1
2012-05-07protein level
2 26 1
2012-04-10protein level
2 26 1
2012-01-13protein level
2 14 1
2011-12-20protein level
2 14 1
2011-11-11protein level
2 14 1
2011-08-23protein level
2 14 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q6S5L8-1
12 18 1 68741.0254
NX_Q6S5L8-2
3 18 0 42754.8857
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-9453524,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
2 EBI-9453524,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
3 EBI-9453524,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain40
connective tissue6
ear62
embryonic tissue4
eye9
intestine4
kidney4
lung2
nerve64
ovary9
pharynx24
salivary gland49
skin14
testis52
uterus4
vascular19
Health State
TissuesTPM*
normal20
colorectal tumor8
germ cell tumor26
head and neck tumor7
kidney tumor14
non-neoplasia10
skin tumor15
Developmental Stage
TissuesTPM*
adult8
fetus21
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland1.2
appendix1.1
cerebral cortex7.9
gallbladder1.7
heart muscle2.7
salivary gland1.6
testis11.7
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)


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