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> Protein (NX_Q6UWE0)
Protein (NX_Q6UWE0)
Protein
Gene SymbolLRSAM1 to neXtProt (NX_Q6UWE0)
DescriptionE3 ubiquitin-protein ligase LRSAM1
Chromosome9
Location9q33.3 (130213765 ~ 130265780) to Ensembl
Sequene Features : Isoforms 3, Variants 76, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.ubiquitin-dependent endocytosis
.protein autoubiquitination
.viral budding
  + 3 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.membrane
.cytoplasm
.extracellular region
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 76 4
2014-09-19protein level
3 61 4
2014-05-27protein level
3 61 4
2014-02-25protein level
3 61 4
2013-12-09protein level
3 41 4
2013-11-01protein level
3 38 2
2013-09-12protein level
3 38 2
2013-08-17protein level
3 38 2
2013-07-15protein level
3 27 2
2013-06-11protein level
3 27 2
2013-02-12protein level
3 16 5
2012-12-20protein level
3 16 5
2012-10-30protein level
3 19 5
2012-10-07protein level
3 19 2
2012-08-24protein level
3 19 2
2012-07-28protein level
3 19 2
2012-06-08protein level
3 24 2
2012-05-07protein level
3 22 2
2012-04-10protein level
3 22 2
2012-01-13protein level
3 10 2
2011-12-20protein level
3 10 2
2011-11-11protein level
3 10 2
2011-08-23protein level
3 10 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q6UWE0-1
0 40 0 83540.7131
NX_Q6UWE0-2
1 38 0 80376.9158
NX_Q6UWE0-3
0 16 0 35046.8524
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-720984,EBI-1052908 UBE2N  
  .protein K63-linked ubiquitination
.nucleotide-binding oligomerization domain containing signaling pathway
.positive regulation of ubiquitin-protein transferase activity
  + 29 more...
.ubiquitin protein ligase activity
.poly(A) RNA binding
.ubiquitin binding
  + 5 more...
.extracellular exosome
.protein complex
.UBC13-UEV1A complex
  + 5 more...
2 EBI-720984,EBI-346882 TSG101  
  .positive regulation of viral budding via host ESCRT complex
.regulation of viral budding via host ESCRT complex
.regulation of extracellular exosome assembly
  + 21 more...
.calcium-dependent protein binding
.virion binding
.ubiquitin binding
  + 4 more...
.extracellular exosome
.late endosome membrane
.endosome membrane
  + 8 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood16
bone41
bone marrow20
brain75
cervix144
connective tissue20
embryonic tissue23
eye47
heart33
intestine4
kidney18
larynx42
liver29
lung26
lymph node89
mammary gland26
mouth30
muscle18
nerve64
ovary29
pancreas42
pharynx24
pituitary gland60
placenta42
prostate10
skin61
spleen37
stomach10
testis16
thymus37
thyroid21
trachea19
uterus51
vascular38
Health State
TissuesTPM*
normal43
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma60
gastrointestinal tumor8
germ cell tumor56
glioma37
head and neck tumor37
kidney tumor29
leukemia74
non-neoplasia10
ovarian tumor39
pancreatic tumor66
primitive neuroectodermal tumor of the CNS62
retinoblastoma43
skin tumor63
soft tissue/muscle tissue tumor7
uterine tumor66
Developmental Stage
TissuesTPM*
adult26
embryoid body71
fetus82
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.5
adrenal gland7.3
appendix6.1
bone marrow8
cerebral cortex11.4
colon5.8
duodenum5.6
esophagus7.2
gallbladder7
heart muscle8.9
kidney6.6
liver5.3
lung7.7
lymph node7.7
ovary9.6
pancreas2.4
placenta5.5
prostate8.7
salivary gland6.1
skin16.6
small intestine6.4
spleen9.4
stomach6.9
testis5.3
thyroid gland7.4
urinary bladder8.6
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineHigh
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleLow
liverLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2High
small intestineMedium
smooth muscleMedium
soft tissue 1Low
soft tissue 2Low
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610933, gene) Leucine-rich repeat- and sterile alpha motif-containing 1; LRSAM1OMIM
2(#614436, phenotype) Charcot-marie-tooth disease, axonal, type 2p; CMT2POMIM


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