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> Protein (NX_Q6UXH8)
Protein (NX_Q6UXH8)
Protein
Gene SymbolCCBE1 to neXtProt (NX_Q6UXH8)
DescriptionCollagen and calcium-binding EGF domain-containing protein 1
Chromosome18
Location18q21.32 (57098172 ~ 57364612) to Ensembl
Sequene Features : Isoforms 3, Variants 107, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of lymphangiogenesis
.positive regulation of vascular endothelial growth factor signaling pathway
.venous blood vessel morphogenesis
  + 6 more...
.collagen binding
.calcium ion binding
.protease binding
.extracellular space
.collagen trimer
.proteinaceous extracellular matrix
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 107 5
2014-09-19protein level
3 81 5
2014-05-27protein level
3 80 5
2014-02-25protein level
3 79 5
2013-12-09protein level
3 63 5
2013-11-01protein level
3 57 5
2013-09-12protein level
3 57 5
2013-08-17protein level
3 57 5
2013-07-15protein level
3 43 5
2013-06-11protein level
3 43 5
2013-02-12protein level
3 25 5
2012-12-20protein level
3 25 5
2012-10-30protein level
3 27 5
2012-10-07protein level
3 27 5
2012-08-24protein level
3 21 5
2012-07-28protein level
3 21 5
2012-06-08protein level
3 21 5
2012-05-07protein level
3 21 5
2012-04-10protein level
3 21 5
2012-01-13protein level
3 14 5
2011-12-20protein level
3 14 5
2011-11-11protein level
3 14 5
2011-08-23protein level
3 14 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q6UXH8-1
8 9 0 44074.1716
NX_Q6UXH8-2
3 3 0 14790.2558
NX_Q6UXH8-3
0 9 0 22585.1804
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3923278,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
2 EBI-3923278,EBI-740929 KLHL12  
  .negative regulation of canonical Wnt signaling pathway
.COPII vesicle coating
.Wnt signaling pathway
  + 2 more...
.N/A .Cul3-RING ubiquitin ligase complex
.ER to Golgi transport vesicle
.cytosol
.Golgi membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone27
bone marrow20
brain10
connective tissue33
embryonic tissue23
intestine8
kidney33
liver34
lung29
nerve64
ovary49
pancreas4
placenta10
prostate5
skin23
uterus4
Health State
TissuesTPM*
normal15
chondrosarcoma60
colorectal tumor8
germ cell tumor15
kidney tumor14
liver tumor72
lung tumor9
non-neoplasia20
ovarian tumor26
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
uterine tumor11
Developmental Stage
TissuesTPM*
adult9
embryoid body14
blastocyst16
fetus37
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.1
adrenal gland11.1
appendix1.8
cerebral cortex1.4
colon2.5
duodenum1
esophagus2.2
heart muscle1.4
kidney3.4
liver4.1
lung10.2
ovary34.9
prostate2.6
skin2.3
small intestine1.9
stomach1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#235510, phenotype) Hennekam lymphangiectasia-lymphedema syndromeOMIM
2(*612753, gene) Collagen and calcium-binding egf domain-containing protein 1; CCBE1OMIM


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