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> Protein (NX_Q6UY14)
Protein (NX_Q6UY14)
Protein
Gene SymbolADAMTSL4 to neXtProt (NX_Q6UY14)
DescriptionADAMTS-like protein 4
Chromosome1
Location1q21.3 (150521884 ~ 150533413) to Ensembl
Sequene Features : Isoforms 3, Variants 161, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 161 8
2014-09-19protein level
3 131 8
2014-05-27protein level
2 129 8
2014-02-25protein level
2 128 8
2013-12-09protein level
2 90 8
2013-11-01protein level
2 87 8
2013-09-12protein level
2 87 8
2013-08-17protein level
2 87 8
2013-07-15protein level
2 64 2
2013-06-11protein level
2 64 2
2013-02-12protein level
2 43 4
2012-12-20protein level
2 44 4
2012-10-30protein level
2 48 4
2012-10-07protein level
2 48 3
2012-08-24protein level
2 46 3
2012-07-28protein level
2 46 3
2012-06-08protein level
2 46 3
2012-05-07protein level
2 40 3
2012-04-10protein level
2 40 3
2012-01-13protein level
2 16 3
2011-12-20protein level
2 16 3
2011-11-11protein level
2 16 3
2011-08-23protein level
2 16 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q6UY14-1
0 54 0 116470.2794
NX_Q6UY14-2
1 41 0 95071.5972
NX_Q6UY14-3
2 53 0 118745.4842
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10173507,EBI-10173491 CLEC18A  
  .N/A .carbohydrate binding .extracellular region
2 EBI-10173507,EBI-725515 FRS3  
  .fibroblast growth factor receptor signaling pathway
.signal transduction
.fibroblast growth factor receptor binding .plasma membrane
3 EBI-10173507,EBI-947402 MAPKBP1  
  .N/A .N/A .N/A
4 EBI-10173507,EBI-398610 EIF4E2  
  .cytokine-mediated signaling pathway
.negative regulation of translation
.in utero embryonic development
.poly(A) RNA binding
.ubiquitin protein ligase binding
.translation factor activity, RNA binding
  + 2 more...
.mRNA cap binding complex
.cytosol
5 EBI-742002,EBI-749295 STK16  
  .cellular response to transforming growth factor beta stimulus
.protein autophosphorylation
.regulation of signal transduction
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.protein serine/threonine kinase activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.perinuclear region of cytoplasm
.membrane
.Golgi-associated vesicle
.cytoplasm
6 EBI-10173507,EBI-2513774 FARS2  
  .gene expression
.tRNA processing
.phenylalanyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.phenylalanine-tRNA ligase activity
.magnesium ion binding
.tRNA binding
.mitochondrial matrix
.mitochondrion
7 EBI-10173507,EBI-373403 TOP3B  
  .chromosome segregation
.DNA topological change
.poly(A) RNA binding
.DNA topoisomerase type I activity
.DNA topoisomerase activity
.DNA binding
.nucleoplasm
.nucleus
.condensed chromosome
8 EBI-742002,EBI-715062 CTSB  
  .cellular response to thyroid hormone stimulus
.proteolysis involved in cellular protein catabolic process
.regulation of catalytic activity
  + 9 more...
.proteoglycan binding
.cysteine-type peptidase activity
.peptidase activity
  + 2 more...
.extracellular exosome
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
  + 8 more...
9 EBI-10173507,EBI-8832659 CST2  
  .negative regulation of endopeptidase activity
.detection of chemical stimulus involved in sensory perception of bitter taste
.cysteine-type endopeptidase inhibitor activity .extracellular space
10 EBI-10173507,EBI-8588553 GIP  
  .triglyceride homeostasis
.positive regulation of glucagon secretion
.long-term synaptic potentiation
  + 22 more...
.hormone activity .neuronal cell body
.secretory granule lumen
.endoplasmic reticulum lumen
  + 2 more...
11 EBI-10173507,EBI-1039104 HGF  
  .positive regulation of DNA biosynthetic process
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of hydrogen peroxide-mediated programmed cell death
  + 25 more...
.identical protein binding
.chemoattractant activity
.growth factor activity
.catalytic activity
.platelet alpha granule lumen
.membrane
.extracellular space
.extracellular region
12 EBI-10173507,EBI-4397076 FAH  
  .small molecule metabolic process
.cellular nitrogen compound metabolic process
.tyrosine catabolic process
  + 2 more...
.metal ion binding
.fumarylacetoacetase activity
.extracellular exosome
.cytosol
13 EBI-10173507,EBI-10200479 SPINK2  
  .negative regulation of endopeptidase activity .serine-type endopeptidase inhibitor activity
.endopeptidase inhibitor activity
.extracellular region
14 EBI-10173507,EBI-9641086 FLNA  
  .positive regulation of integrin-mediated signaling pathway
.positive regulation of substrate adhesion-dependent cell spreading
.mitotic spindle assembly
  + 24 more...
.actin filament binding
.Rac GTPase binding
.poly(A) RNA binding
  + 8 more...
.apical dendrite
.extracellular exosome
.perinuclear region of cytoplasm
  + 15 more...
15 EBI-10173507,EBI-2806671 GATA2  
  .regulation of forebrain neuron differentiation
.negative regulation of neural precursor cell proliferation
.GABAergic neuron differentiation
  + 29 more...
.C2H2 zinc finger domain binding
.zinc ion binding
.transcription factor binding
  + 5 more...
.protein complex
.nucleoplasm
16 EBI-10173507,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
17 EBI-10173507,EBI-8639312 LMO1  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.zinc ion binding .nucleus
18 EBI-10173507,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
19 EBI-10173507,EBI-3907456 NTF4  
  .taste bud development
.innervation
.neuron projection morphogenesis
  + 10 more...
.growth factor activity
.neurotrophin p75 receptor binding
.cytoplasmic membrane-bounded vesicle
.endoplasmic reticulum lumen
.extracellular region
20 EBI-10173507,EBI-740785 HOXA1  
  .cochlea morphogenesis
.cochlea development
.cellular response to retinoic acid
  + 24 more...
.sequence-specific DNA binding .nucleus
21 EBI-10173507,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
22 EBI-10173507,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
23 EBI-10173507,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
24 EBI-10173507,EBI-10217483 KRTAP10-11  
  .N/A .N/A .keratin filament
25 EBI-10173507,EBI-6693977 FKBP1B  
  .cell communication by electrical coupling involved in cardiac conduction
.calcium ion transmembrane transport
.negative regulation of insulin secretion involved in cellular response to glucose stimulus
  + 27 more...
.ion channel binding
.cyclic nucleotide binding
.calcium channel inhibitor activity
  + 3 more...
.calcium channel complex
.sarcoplasmic reticulum membrane
.Z disc
  + 3 more...
26 EBI-10173507,EBI-10192698 CREB5  
  .adipose tissue development
.positive regulation of transcription, DNA-templated
.fat cell differentiation
.transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.extracellular exosome
.nucleus
27 EBI-10173507,EBI-10181276 GOLGA8DP  
  .N/A .N/A .Golgi apparatus
28 EBI-10173507,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
29 EBI-10173507,EBI-10233719 DIP2A  
  .regulation of apoptotic process
.negative regulation of gene expression
.multicellular organismal development
.catalytic activity .cell surface
.nucleus
30 EBI-10173507,EBI-710310 TCEA2  
  .positive regulation of transcription from RNA polymerase II promoter
.regulation of DNA-templated transcription, elongation
.DNA-templated transcription, elongation
.zinc ion binding
.DNA binding
.transcription elongation factor complex
.centrosome
.nucleoplasm
31 EBI-10173507,EBI-742327 TRIP6  
  .focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
.cytoskeleton
  + 2 more...
32 EBI-10173507,EBI-2341787 LONRF1  
  .N/A .zinc ion binding
.ATP-dependent peptidase activity
.N/A
33 EBI-10173507,EBI-10245291 LCE3C  
  .keratinization .N/A .N/A
34 EBI-10173507,EBI-10245456 LCE3E  
  .keratinization .N/A .N/A
35 EBI-10173507,EBI-10245913 LCE1B  
  .keratinization .N/A .N/A
36 EBI-10173507,EBI-10246358 LCE4A  
  .keratinization .N/A .N/A
37 EBI-10173507,EBI-10246750 LCE2D  
  .keratinization .N/A .N/A
38 EBI-10173507,EBI-10250562 KRTAP5-6  
  .N/A .N/A .keratin filament
39 EBI-10173507,EBI-9675802 MORN3  
  .N/A .N/A .nucleus
40 EBI-10173507,EBI-8635958 SPATA8  
  .N/A .N/A .N/A
41 EBI-10173507,EBI-10254938 ADAMTSL5  
  .N/A .zinc ion binding
.heparin binding
.metalloendopeptidase activity
.proteinaceous extracellular matrix
.extracellular region
.microfibril
42 EBI-10173507,EBI-10256685 PID1  
  .negative regulation of glucose import in response to insulin stimulus
.positive regulation of ATP biosynthetic process
.negative regulation of ATP biosynthetic process
  + 19 more...
.N/A .cytoplasm
.nucleoplasm
43 EBI-10173507,EBI-2799342 TMEM150A  
  .regulation of autophagy
.catabolic process
.N/A .integral component of membrane
.plasma membrane
.lysosome
44 EBI-10173507,EBI-5235829 TRIM42  
  .N/A .zinc ion binding .intracellular
45 EBI-10173507,EBI-749051 C6orf165  
  .N/A .N/A .N/A
46 EBI-10173507,EBI-8656665 NATD1  
  .N/A .N/A .N/A
47 EBI-10173507,EBI-745707 GMCL1P1  
  .cell differentiation
.protein ubiquitination
.spermatogenesis
.multicellular organismal development
.N/A .nuclear matrix
48 EBI-10173507,EBI-10271580 CCDC26  
  .N/A .N/A .N/A
49 EBI-10173507,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
50 EBI-10173507,EBI-10274069 LGALS14  
  .positive regulation of T cell apoptotic process
.apoptotic process
.carbohydrate binding .nucleus
51 EBI-10173507,EBI-5542466 RAB2B  
  .positive regulation of exocytosis
.Rab protein signal transduction
.vesicle-mediated transport
  + 2 more...
.GTP binding
.GTPase activity
.extracellular exosome
.plasma membrane
.endoplasmic reticulum membrane
.Golgi membrane
52 EBI-10173507,EBI-10276755 LRRC29  
  .N/A .N/A .N/A
53 EBI-10173507,EBI-2866213 KIAA0247  
  .cell death
.cellular response to DNA damage stimulus
.N/A .integral component of membrane
54 EBI-10173507,EBI-355653 SMARCC1  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
  + 8 more...
.protein N-terminus binding
.transcription coactivator activity
.chromatin binding
.DNA binding
.nBAF complex
.npBAF complex
.protein complex
  + 4 more...
55 EBI-10173507,EBI-741068 FBXW5  
  .centrosome duplication
.proteasome-mediated ubiquitin-dependent protein catabolic process
.SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  + 2 more...
.protein kinase binding .Cul4-RING E3 ubiquitin ligase complex
.SCF ubiquitin ligase complex
.cytoplasm
56 EBI-10173507,EBI-10292253 OLFM3  
  .eye photoreceptor cell development .N/A .synapse
.alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
.cell junction
  + 2 more...
57 EBI-10173507,EBI-947779 RCHY1  
  .error-free translesion synthesis
.protein autoubiquitination
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 5 more...
.protein homodimerization activity
.ligase activity
.zinc ion binding
  + 2 more...
.nuclear speck
.cytoplasm
.nucleoplasm
  + 2 more...
58 EBI-10173507,EBI-3918381 TSSK3  
  .intracellular signal transduction
.cell differentiation
.regulation of signal transduction
  + 3 more...
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.cytoplasm
.nucleus
59 EBI-10173507,EBI-6427977 ZNF587  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
60 EBI-10173507,EBI-8633740 CYP2S1  
  .oxidation-reduction process
.small molecule metabolic process
.exogenous drug catabolic process
  + 2 more...
.aromatase activity
.heme binding
.oxygen binding
  + 4 more...
.intracellular membrane-bounded organelle
.endoplasmic reticulum membrane
.endoplasmic reticulum
.cytoplasm
61 EBI-10173507,EBI-10294182 DSCR8  
  .N/A .N/A .N/A
62 EBI-10173507,EBI-739863 KRTAP4-12  
  .N/A .N/A .keratin filament
63 EBI-10173507,EBI-10185730 KRTAP9-4  
  .N/A .N/A .keratin filament
64 EBI-10173507,EBI-1044640 KRTAP9-2  
  .N/A .N/A .keratin filament
65 EBI-10173507,EBI-10302392 KRTAP4-11  
  .N/A .N/A .keratin filament
66 EBI-10173507,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
67 EBI-10173507,EBI-1993677 ASPSCR1  
  .membrane organization
.regulation of glucose import
.glucose homeostasis
.intracellular protein transport
.N/A .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.endoplasmic reticulum-Golgi intermediate compartment membrane
  + 7 more...
68 EBI-10173507,EBI-10303844 NMUR2  
  .chloride transmembrane transport
.arachidonic acid secretion
.response to pain
  + 14 more...
.neuromedin U binding
.GTP binding
.intracellular calcium activated chloride channel activity
  + 2 more...
.integral component of membrane
.plasma membrane
69 EBI-10173507,EBI-6285694 RHOJ  
  .retina vasculature morphogenesis in camera-type eye
.regulation of small GTPase mediated signal transduction
.actin cytoskeleton organization
  + 4 more...
.GTP binding
.GTPase activity
.extracellular exosome
.plasma membrane
.cytosol
70 EBI-10173507,EBI-741626 FAM124B  
  .N/A .N/A .N/A
71 EBI-10173507,EBI-10311198 SLC6A20  
  .transmembrane transport
.proline transport
.glycine transport
  + 3 more...
.amino acid transmembrane transporter activity
.neurotransmitter:sodium symporter activity
.apical plasma membrane
.integral component of plasma membrane
.plasma membrane
72 EBI-10173507,EBI-10313866 C19orf66  
  .N/A .N/A .N/A
73 EBI-10173507,EBI-744841 CPNE7  
  .cellular response to calcium ion
.glycerophospholipid biosynthetic process
.small molecule metabolic process
  + 3 more...
.transporter activity .extracellular exosome
.plasma membrane
.cytoplasm
.nucleus
74 EBI-10173507,EBI-1759386 SLC23A1  
  .transepithelial L-ascorbic acid transport
.dehydroascorbic acid transport
.small molecule metabolic process
  + 12 more...
.sodium-dependent L-ascorbate transmembrane transporter activity
.dehydroascorbic acid transporter activity
.L-ascorbic acid transporter activity
  + 3 more...
.extracellular exosome
.intracellular organelle
.apical plasma membrane
  + 6 more...
75 EBI-10173507,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
76 EBI-10173507,EBI-4291090 GNE  
  .carbohydrate phosphorylation
.cellular protein metabolic process
.post-translational protein modification
  + 6 more...
.metal ion binding
.N-acylmannosamine kinase activity
.UDP-N-acetylglucosamine 2-epimerase activity
  + 2 more...
.cytosol
.cytoplasm
77 EBI-10173507,EBI-8583355 AMMECR1  
  .N/A .N/A .N/A
78 EBI-10173507,EBI-2321769 CHCHD2  
  .regulation of cellular response to hypoxia
.positive regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.sequence-specific DNA binding
.transcription factor binding
.mitochondrion
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue310
ascites25
blood16
bone27
bone marrow61
brain2
connective tissue33
embryonic tissue56
eye19
heart33
liver29
lung41
mammary gland13
mouth15
ovary29
pancreas4
pharynx49
placenta293
prostate15
salivary gland49
skin18
spleen37
stomach10
testis2
uterus17
Health State
TissuesTPM*
normal41
bladder carcinoma56
chondrosarcoma108
gastrointestinal tumor8
germ cell tumor18
glioma9
head and neck tumor29
leukemia10
liver tumor62
lung tumor38
non-neoplasia31
pancreatic tumor9
skin tumor7
Developmental Stage
TissuesTPM*
adult65
embryoid body114
blastocyst65
fetus28
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue27.5
adrenal gland4.3
appendix17.1
bone marrow3.5
colon10.3
duodenum4
esophagus29.5
gallbladder12
heart muscle12.2
kidney2
liver11.7
lung30
lymph node2.6
ovary5
pancreas2
placenta116.3
prostate8
salivary gland8.4
skin6.3
small intestine5.9
spleen8.8
stomach6.3
testis5.1
thyroid gland3.3
urinary bladder19.9
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexHigh
colonLow
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderLow
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungHigh
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#225100, phenotype) Ectopia lentis, isolated, autosomal recessive; ECTOL2OMIM
2(%225200, phenotype) Ectopia lentis et pupillaeOMIM
3(*610113, gene) Adamts-like 4; ADAMTSL4OMIM


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