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> Protein (NX_Q6ZVK8)
Protein (NX_Q6ZVK8)
Protein
Gene SymbolNUDT18 to neXtProt (NX_Q6ZVK8)
Description8-oxo-dGDP phosphatase NUDT18
Chromosome8
Location8p21.3 (21964383 ~ 21966932) to Ensembl
Sequene Features : Isoforms 2, Variants 23, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.nucleobase-containing small molecule metabolic process
.GDP catabolic process
.dGDP catabolic process
  + 3 more...
.8-hydroxy-dADP phosphatase activity
.8-oxo-GDP phosphatase activity
.8-oxo-dGDP phosphatase activity
.magnesium ion binding
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 23 0
2014-09-19protein level
2 18 0
2014-05-27protein level
2 18 0
2014-02-25protein level
2 18 0
2013-12-09protein level
2 10 0
2013-11-01protein level
2 10 0
2013-09-12protein level
2 10 0
2013-08-17protein level
2 10 0
2013-07-15protein level
2 7 0
2013-06-11protein level
2 7 0
2013-02-12protein level
2 3 0
2012-12-20protein level
2 4 0
2012-10-30protein level
2 6 0
2012-10-07protein level
2 6 0
2012-08-24protein level
2 5 0
2012-07-28protein level
2 5 0
2012-06-08protein level
2 7 0
2012-05-07protein level
2 7 0
2012-04-10protein level
2 7 0
2012-01-13protein level
2 5 0
2011-12-20protein level
2 5 0
2011-11-11protein level
2 3 0
2011-08-23protein level
2 3 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q6ZVK8-1
6 12 0 35478.2682
NX_Q6ZVK8-2
1 12 0 24447.7224
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740486,EBI-712261 PAICS  
  .nucleobase-containing small molecule metabolic process
.small molecule metabolic process
.purine ribonucleoside monophosphate biosynthetic process
  + 3 more...
.identical protein binding
.ATP binding
.phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
.phosphoribosylaminoimidazole carboxylase activity
.extracellular exosome
.membrane
.cytosol
2 EBI-740486,EBI-353224 DUT  
  .nucleobase-containing small molecule metabolic process
.pyrimidine nucleoside biosynthetic process
.dUTP catabolic process
  + 5 more...
.poly(A) RNA binding
.dUTP diphosphatase activity
.magnesium ion binding
.extracellular exosome
.mitochondrion
.nucleoplasm
.nucleus
3 EBI-740486,EBI-741925 DHPS  
  .protein homotetramerization
.deoxyhypusine biosynthetic process from spermidine
.cellular protein metabolic process
  + 6 more...
.deoxyhypusine synthase activity .cytosol
4 EBI-740486,EBI-742084 NT5C2  
  .nucleobase-containing small molecule metabolic process
.adenosine metabolic process
.IMP metabolic process
  + 6 more...
.nucleoside phosphotransferase activity
.metal ion binding
.5'-nucleotidase activity
.nucleotide binding
.cytosol
5 EBI-740486,EBI-743796 RAB3IL1  
  .positive regulation of GTPase activity
.protein transport
.Rab guanyl-nucleotide exchange factor activity .N/A
6 EBI-740486,EBI-749523 EVI5L  
  .negative regulation of cilium assembly
.positive regulation of GTPase activity
.Rab GTPase binding
.GTPase activator activity
.N/A
7 EBI-740486,EBI-359248 APIP  
  .regulation of ERK1 and ERK2 cascade
.small molecule metabolic process
.negative regulation of apoptotic process
  + 6 more...
.methylthioribulose 1-phosphate dehydratase activity
.identical protein binding
.zinc ion binding
.cytoplasm
8 EBI-740486,EBI-742664 HSD17B14  
  .steroid catabolic process .testosterone 17-beta-dehydrogenase (NADP+) activity
.estradiol 17-beta-dehydrogenase activity
.cytosol
9 EBI-740486,EBI-712367 RABAC1  
  .N/A .identical protein binding .cell junction
.integral component of membrane
.membrane
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
blood16
brain2
embryonic tissue4
eye9
intestine8
kidney4
lung2
lymph node11
mammary gland6
ovary19
pancreas4
placenta14
prostate31
salivary gland49
testis2
uterus17
Health State
TissuesTPM*
normal3
breast (mammary gland) tumor10
chondrosarcoma12
colorectal tumor17
gastrointestinal tumor8
glioma18
head and neck tumor7
leukemia10
prostate cancer9
retinoblastoma21
skin tumor15
soft tissue/muscle tissue tumor7
uterine tumor33
Developmental Stage
TissuesTPM*
adult4
embryoid body14
fetus3
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.5
adrenal gland3.3
appendix4.4
bone marrow2.7
cerebral cortex3.7
colon5.1
duodenum5.7
esophagus4
gallbladder4.6
heart muscle2.7
kidney4.9
liver1.3
lung5.7
lymph node8.2
ovary1.6
pancreas4.9
placenta2.4
prostate5.3
salivary gland4.7
skin3.6
small intestine5.6
spleen7.5
stomach6.4
testis4.9
thyroid gland5.9
urinary bladder4.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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