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> Protein (NX_Q719H9)
Protein (NX_Q719H9)
Protein
Gene SymbolKCTD1 to neXtProt (NX_Q719H9)
DescriptionBTB/POZ domain-containing protein KCTD1
Chromosome18
Location18q11.2 (24034874 ~ 24237365) to Ensembl
Sequene Features : Isoforms 1, Variants 38, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein homooligomerization
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.transcription factor binding
.transcription corepressor activity
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 38 2
2014-09-19protein level
1 35 2
2014-05-27protein level
1 35 2
2014-02-25protein level
1 35 2
2013-12-09protein level
1 29 2
2013-11-01protein level
1 27 2
2013-09-12protein level
1 19 2
2013-08-17protein level
1 19 2
2013-07-15protein level
1 10 2
2013-06-11protein level
1 10 2
2013-02-12protein level
1 6 2
2012-12-20protein level
1 6 2
2012-10-30protein level
1 7 2
2012-10-07protein level
1 7 2
2012-08-24protein level
1 4 2
2012-07-28protein level
1 4 2
2012-06-08protein level
1 5 2
2012-05-07protein level
1 5 2
2012-04-10protein level
1 5 2
2012-01-13protein level
1 3 2
2011-12-20protein level
1 3 2
2011-11-11protein level
1 3 2
2011-08-23protein level
1 3 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q719H9-1
11 0 1 29385.9064
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-9027502,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-9027502,EBI-1055079 POLR1C  
  .negative regulation of gene expression, epigenetic
.innate immune response
.regulation of gene expression, epigenetic
  + 9 more...
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase I complex
.DNA-directed RNA polymerase III complex
.nucleoplasm
3 EBI-9027502,EBI-5663373 TRAPPC2  
  .ER to Golgi vesicle-mediated transport
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.skeletal system development
.ion channel binding
.transcription factor binding
.perinuclear region of cytoplasm
.Golgi apparatus
.endoplasmic reticulum
.nucleus
4 EBI-9027502,EBI-739899 ZBTB25  
  .gene expression
.transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.cytoplasm
.nucleoplasm
5 EBI-9027502,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
6 EBI-9027502,EBI-1383852 PRKAA2  
  .regulation of energy homeostasis
.membrane organization
.fatty acid homeostasis
  + 31 more...
.[acetyl-CoA carboxylase] kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
.metal ion binding
  + 7 more...
.AMP-activated protein kinase complex
.cytosol
.cytoplasm
.nucleoplasm
7 EBI-9027502,EBI-6255981 EPM2AIP1  
  .positive regulation of glycogen (starch) synthase activity
.positive regulation of glycogen biosynthetic process
.response to insulin
.N/A .endoplasmic reticulum
.nucleus
8 EBI-9027502,EBI-742259 LMO3  
  .positive regulation of glucocorticoid receptor signaling pathway
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of fat cell differentiation
  + 3 more...
.zinc ion binding .cytoplasm
9 EBI-9027502,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
10 EBI-9027502,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
11 EBI-9027502,EBI-715783 KCTD15  
  .protein homooligomerization
.multicellular organismal development
.N/A .N/A
12 EBI-9027502,EBI-371892 EXOSC1  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.rRNA processing
.nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.RNA binding .cytosol
.cytoplasm
.nucleolus
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood24
bone41
brain19
cervix20
connective tissue20
embryonic tissue28
eye43
heart55
intestine4
kidney37
larynx42
liver9
lung44
lymph node33
mammary gland13
ovary19
pancreas37
parathyroid48
placenta52
skin23
stomach20
testis16
thymus12
thyroid21
uterus47
Health State
TissuesTPM*
normal27
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma12
germ cell tumor15
glioma37
head and neck tumor7
leukemia31
lung tumor19
non-neoplasia10
ovarian tumor26
pancreatic tumor19
primitive neuroectodermal tumor of the CNS23
soft tissue/muscle tissue tumor15
uterine tumor77
Developmental Stage
TissuesTPM*
adult26
embryoid body57
blastocyst32
fetus25
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.6
adrenal gland13.8
appendix2.9
cerebral cortex25
colon5
duodenum2.6
esophagus31.9
gallbladder7.9
heart muscle12.1
kidney16.8
liver1.6
lung4.4
lymph node2
ovary11.7
pancreas3.2
placenta10.3
prostate15.1
salivary gland11.2
skin43.1
small intestine2.1
spleen2.8
stomach6.2
testis4.5
thyroid gland12.3
urinary bladder9.6
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(%181270, phenotype) Scalp-ear-nipple syndromeOMIM
2(*613420, gene) Potassium channel tetramerization domain-containing 1; KCTD1OMIM


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