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> Protein (NX_Q76LX8)
Protein (NX_Q76LX8)
Protein
Gene SymbolADAMTS13 to neXtProt (NX_Q76LX8)
DescriptionA disintegrin and metalloproteinase with thrombospondin motifs 13
Chromosome9
Location9q34.2 (136279478 ~ 136324508) to Ensembl
Sequene Features : Isoforms 4, Variants 231, PTMs 30 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.response to interleukin-4
.cellular protein metabolic process
.post-translational protein modification
  + 12 more...
.zinc ion binding
.metallopeptidase activity
.calcium ion binding
  + 2 more...
.cell surface
.endoplasmic reticulum lumen
.extracellular space
.proteinaceous extracellular matrix
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 231 30
2014-09-19protein level
4 184 30
2014-05-27protein level
3 180 26
2014-02-25protein level
3 179 26
2013-12-09protein level
3 159 26
2013-11-01protein level
3 155 26
2013-09-12protein level
3 155 21
2013-08-17protein level
3 155 21
2013-07-15protein level
3 125 21
2013-06-11protein level
3 125 21
2013-02-12protein level
3 103 62
2012-12-20protein level
3 101 62
2012-10-30protein level
3 101 44
2012-10-07protein level
3 101 15
2012-08-24protein level
3 101 15
2012-07-28protein level
3 101 15
2012-06-08protein level
3 105 15
2012-05-07protein level
3 75 15
2012-04-10protein level
3 75 15
2012-01-13protein level
3 47 15
2011-12-20protein level
3 47 15
2011-11-11protein level
3 47 15
2011-08-23protein level
3 47 15
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q76LX8-1
4 59 0 153504.2044
NX_Q76LX8-2
0 60 0 147707.2488
NX_Q76LX8-3
1 58 0 144422.6894
NX_Q76LX8-4
3 14 0 39837.9573
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-981764,EBI-981819 VWF  
  .protein homooligomerization
.cell-substrate adhesion
.extracellular matrix organization
  + 9 more...
.chaperone binding
.protein N-terminus binding
.protein homodimerization activity
  + 6 more...
.extracellular exosome
.Weibel-Palade body
.platelet alpha granule lumen
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
brain8
connective tissue6
eye4
intestine30
kidney14
liver19
nerve64
ovary19
placenta3
testis29
thyroid21
Health State
TissuesTPM*
normal6
germ cell tumor11
head and neck tumor7
kidney tumor14
ovarian tumor39
Developmental Stage
TissuesTPM*
adult8
fetus3
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.3
adrenal gland1.4
cerebral cortex3.2
colon1.6
duodenum3.6
esophagus1
gallbladder1.9
heart muscle2
kidney1.8
liver15.2
lung1.5
lymph node1.3
ovary2.6
pancreas1.2
placenta1
prostate2.3
salivary gland1.2
skin2.3
small intestine2.1
stomach4.9
testis6.8
thyroid gland2
urinary bladder1.3
Tissues
TissuesExpression level
adrenal glandHigh
appendixLow
breastLow
bronchusMedium
cerebral cortexLow
colonLow
duodenumMedium
gallbladderMedium
kidneyHigh
liverHigh
lungLow
nasopharynxLow
pancreasMedium
placentaMedium
rectumMedium
skin 2Low
small intestineMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#274150, phenotype) Thrombotic thrombocytopenic purpura, congenital; TTPOMIM
2(*604134, gene) A disintegrin-like and metalloprotease with thrombospondin type 1OMIM


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