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> Protein (NX_Q7KZ85)
Protein (NX_Q7KZ85)
Protein
Gene SymbolSUPT6H to neXtProt (NX_Q7KZ85)
DescriptionTranscription elongation factor SPT6
Chromosome17
Location17q11.2 (26989109 ~ 27029697) to Ensembl
Sequene Features : Isoforms 3, Variants 175, PTMs 32 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of histone H3-K27 methylation
.regulation of muscle cell differentiation
.mRNA transport
  + 10 more...
.poly(A) RNA binding
.histone binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 175 32
2014-09-19protein level
3 121 32
2014-05-27protein level
3 121 32
2014-02-25protein level
3 118 32
2013-12-09protein level
3 102 32
2013-11-01protein level
3 93 24
2013-09-12protein level
3 93 24
2013-08-17protein level
3 93 24
2013-07-15protein level
3 58 24
2013-06-11protein level
3 58 24
2013-02-12protein level
3 22 47
2012-12-20protein level
3 22 47
2012-10-30protein level
3 24 47
2012-10-07protein level
3 24 22
2012-08-24protein level
3 21 22
2012-07-28protein level
3 21 22
2012-06-08protein level
3 5 22
2012-05-07protein level
3 5 22
2012-04-10protein level
3 5 22
2012-01-13protein level
3 5 22
2011-12-20protein level
3 5 22
2011-11-11protein level
3 5 21
2011-08-23protein level
3 5 20
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q7KZ85-1
29 45 0 198948.0413
NX_Q7KZ85-2
2 21 0 61262.2625
NX_Q7KZ85-3
1 27 0 84579.9702
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2515547,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites100
blood73
bone69
bone marrow20
brain72
cervix82
connective tissue100
embryonic tissue108
eye138
heart44
intestine150
kidney142
larynx42
liver53
lung164
lymph67
lymph node89
mammary gland145
mouth105
muscle28
ovary19
pancreas23
parathyroid97
pharynx24
pituitary gland60
placenta60
prostate36
salivary gland49
skin113
spleen37
stomach41
testis32
thymus87
thyroid107
trachea77
umbilical cord581
uterus73
vascular19
Health State
TissuesTPM*
normal67
breast (mammary gland) tumor204
cervical tumor115
chondrosarcoma169
colorectal tumor222
gastrointestinal tumor84
germ cell tumor60
glioma83
head and neck tumor82
kidney tumor116
leukemia116
liver tumor93
lung tumor233
lymphoma69
non-neoplasia62
ovarian tumor13
pancreatic tumor28
primitive neuroectodermal tumor of the CNS23
prostate cancer9
retinoblastoma172
skin tumor167
soft tissue/muscle tissue tumor31
uterine tumor110
Developmental Stage
TissuesTPM*
adult105
embryoid body114
blastocyst130
neonate64
fetus68
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue23.6
adrenal gland28.3
appendix25.6
bone marrow40.8
cerebral cortex24.2
colon20.5
duodenum17.6
esophagus22.3
gallbladder26.8
heart muscle17.7
kidney23.5
liver19.2
lung25.4
lymph node26
ovary29.8
pancreas13
placenta26.8
prostate23.9
salivary gland18.8
skin31.1
small intestine16.8
spleen27.4
stomach23.1
testis24.3
thyroid gland24.4
urinary bladder23.8
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowHigh
breastHigh
bronchusHigh
cerebellumMedium
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Low
endometrium 2High
epididymisMedium
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleLow
hippocampusMedium
kidneyLow
lateral ventricleMedium
liverLow
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateLow
rectumMedium
salivary glandHigh
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenLow
stomach 1High
stomach 2High
testisMedium
thyroid glandHigh
tonsilMedium
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601333, gene) Suppressor of ty 6, s. cerevisiae, homolog of; SUPT6HOMIM


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