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> Protein (NX_Q7KZI7)
Protein (NX_Q7KZI7)
Protein
Gene SymbolMARK2 to neXtProt (NX_Q7KZI7)
DescriptionSerine/threonine-protein kinase MARK2
Chromosome11
Location11q13.1 (63606400 ~ 63678491) to Ensembl
Sequene Features : Isoforms 16, Variants 104, PTMs 26 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.mitochondrion localization
.regulation of cytoskeleton organization
.regulation of axonogenesis
  + 11 more...
.tau-protein kinase activity
.poly(A) RNA binding
.protein kinase activator activity
  + 4 more...
.microtubule bundle
.basal cortex
.lateral plasma membrane
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
16 104 26
2014-09-19protein level
16 65 26
2014-05-27protein level
16 65 27
2014-02-25protein level
16 65 27
2013-12-09protein level
16 58 27
2013-11-01protein level
16 54 25
2013-09-12protein level
16 54 26
2013-08-17protein level
16 54 26
2013-07-15protein level
16 38 26
2013-06-11protein level
16 38 26
2013-02-12protein level
16 19 586
2012-12-20protein level
16 21 586
2012-10-30protein level
16 19 586
2012-10-07protein level
16 19 38
2012-08-24protein level
16 16 38
2012-07-28protein level
16 15 38
2012-06-08protein level
16 20 38
2012-05-07protein level
16 12 38
2012-04-10protein level
16 12 38
2012-01-13protein level
16 13 38
2011-12-20protein level
16 13 38
2011-11-11protein level
16 13 39
2011-08-23protein level
14 13 32
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q7KZI7-1
0 31 8 87855.6802
NX_Q7KZI7-10
0 24 8 77020.3357
NX_Q7KZI7-11
0 30 8 86074.7787
NX_Q7KZI7-12
0 28 8 82499.0252
NX_Q7KZI7-13
0 25 8 77582.5676
NX_Q7KZI7-14
0 29 8 83061.2571
NX_Q7KZI7-15
0 26 8 79377.4196
NX_Q7KZI7-16
0 27 8 81158.3211
NX_Q7KZI7-2
0 25 8 78801.2372
NX_Q7KZI7-3
0 29 8 83132.294
NX_Q7KZI7-4
0 27 8 81229.358
NX_Q7KZI7-5
0 26 8 80596.0892
NX_Q7KZI7-6
0 29 8 84279.9267
NX_Q7KZI7-7
0 25 8 77653.6045
NX_Q7KZI7-8
0 31 8 86708.0475
NX_Q7KZI7-9
0 27 8 82376.9907
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-516560,EBI-366182 MAPT  
  .regulation of microtubule-based movement
.generation of neurons
.axon extension
  + 13 more...
.lipoprotein particle binding
.apolipoprotein binding
.enzyme binding
  + 3 more...
.tubulin complex
.cytoplasmic ribonucleoprotein granule
.nuclear periphery
  + 7 more...
2 EBI-516560,EBI-359815 YWHAB  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 24 more...
.phosphoprotein binding
.phosphoserine binding
.histone deacetylase binding
  + 3 more...
.extracellular exosome
.perinuclear region of cytoplasm
.melanosome
  + 7 more...
3 EBI-516560,EBI-359832 YWHAG  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of protein serine/threonine kinase activity
  + 14 more...
.poly(A) RNA binding
.protein kinase C inhibitor activity
.insulin-like growth factor receptor binding
.protein kinase C binding
.extracellular exosome
.cytoplasmic vesicle membrane
.membrane
  + 2 more...
4 EBI-516560,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
5 EBI-516560,EBI-306940 YWHAH  
  .regulation of sodium ion transmembrane transporter activity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
  + 16 more...
.protein heterodimerization activity
.ion channel binding
.glucocorticoid receptor binding
  + 4 more...
.extracellular exosome
.cytoplasmic vesicle membrane
.intercalated disc
  + 3 more...
6 EBI-516560,EBI-295417 PARD6G  
  .tight junction assembly
.cell division
.cell-cell junction organization
  + 2 more...
.N/A .protein complex
.tight junction
.plasma membrane
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder66
blood16
bone83
brain26
cervix123
connective tissue13
embryonic tissue37
eye28
heart11
intestine77
kidney28
larynx170
liver4
lung35
lymph158
lymph node11
mammary gland66
mouth75
muscle37
nerve64
ovary29
pancreas60
pharynx294
pituitary gland60
placenta52
prostate42
salivary gland148
skin28
stomach20
testis18
thymus12
thyroid21
uterus56
vascular19
Health State
TissuesTPM*
normal29
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor85
cervical tumor86
chondrosarcoma24
colorectal tumor88
gastrointestinal tumor25
germ cell tumor37
glioma18
head and neck tumor171
kidney tumor72
leukemia63
lung tumor58
lymphoma124
non-neoplasia10
ovarian tumor39
pancreatic tumor57
primitive neuroectodermal tumor of the CNS23
prostate cancer19
skin tumor47
soft tissue/muscle tissue tumor55
uterine tumor99
Developmental Stage
TissuesTPM*
adult53
embryoid body28
blastocyst48
fetus19
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.2
adrenal gland10.7
appendix21.9
bone marrow15.8
cerebral cortex16.7
colon24.7
duodenum23.6
esophagus39.1
gallbladder19.9
heart muscle16.2
kidney12.2
liver5.2
lung16.1
lymph node23.4
ovary12.2
pancreas10.4
placenta18.6
prostate18.6
salivary gland20.4
skin27
small intestine24.6
spleen20.2
stomach20.1
testis12.3
thyroid gland25.6
urinary bladder20.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600526, gene) Map/microtubule affinity-regulating kinase 2; MARK2OMIM


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