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> Protein (NX_Q7L0Q8)
Protein (NX_Q7L0Q8)
Protein
Gene SymbolRHOU to neXtProt (NX_Q7L0Q8)
DescriptionRho-related GTP-binding protein RhoU
Chromosome1
Location1q42.13 (228870824 ~ 228882416) to Ensembl
Sequene Features : Isoforms 2, Variants 28, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of protein targeting to mitochondrion
.regulation of small GTPase mediated signal transduction
.actin cytoskeleton organization
  + 5 more...
.metal ion binding
.GTP binding
.GTPase activity
.cell projection
.focal adhesion
.plasma membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 28 1
2014-09-19protein level
2 23 1
2014-05-27protein level
2 23 1
2014-02-25protein level
2 22 1
2013-12-09protein level
2 18 1
2013-11-01protein level
2 18 1
2013-09-12protein level
2 18 1
2013-08-17protein level
2 18 1
2013-07-15protein level
2 14 1
2013-06-11protein level
2 14 1
2013-02-12protein level
2 6 2
2012-12-20protein level
2 6 2
2012-10-30protein level
2 8 2
2012-10-07protein level
2 8 1
2012-08-24protein level
2 8 1
2012-07-28protein level
2 8 1
2012-06-08protein level
2 12 1
2012-05-07protein level
2 12 1
2012-04-10protein level
2 12 1
2012-01-13protein level
2 12 1
2011-12-20protein level
2 12 1
2011-11-11protein level
2 10 1
2011-08-23protein level
2 10 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q7L0Q8-1
4 6 1 28200.127
NX_Q7L0Q8-2
1 6 0 22150.0499
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1638043,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
2 EBI-1638043,EBI-1019502 PAK1  
  .negative regulation of cell proliferation involved in contact inhibition
.positive regulation of stress fiber assembly
.T cell receptor signaling pathway
  + 32 more...
.Rac GTPase binding
.ATP binding
.collagen binding
  + 2 more...
.protein complex
.ruffle membrane
.nuclear membrane
  + 12 more...
3 EBI-1638043,EBI-298640 PTK2B  
  .positive regulation of B cell chemotaxis
.positive regulation of excitatory postsynaptic membrane potential
.positive regulation of reactive oxygen species metabolic process
  + 84 more...
.ATP binding
.receptor binding
.N-methyl-D-aspartate selective glutamate receptor activity
  + 4 more...
.apical dendrite
.perinuclear region of cytoplasm
.membrane raft
  + 16 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland91
bladder66
blood40
bone97
brain58
connective tissue40
embryonic tissue32
esophagus49
eye62
heart33
intestine34
kidney33
larynx42
liver24
lung47
muscle28
nerve64
ovary19
pancreas14
parathyroid97
pituitary gland60
placenta70
prostate79
testis20
thyroid42
trachea19
uterus81
vascular19
Health State
TissuesTPM*
normal48
adrenal tumor158
colorectal tumor44
esophageal tumor57
germ cell tumor75
glioma93
head and neck tumor22
kidney tumor58
leukemia52
liver tumor20
lung tumor9
non-neoplasia165
pancreatic tumor9
primitive neuroectodermal tumor of the CNS15
prostate cancer144
uterine tumor66
Developmental Stage
TissuesTPM*
adult53
embryoid body100
fetus66
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue21.7
adrenal gland20.7
appendix11.3
bone marrow9.1
cerebral cortex35.1
colon22.6
duodenum38.7
esophagus11.6
gallbladder33.6
heart muscle4.1
kidney5.3
liver28.6
lung15
lymph node7.3
ovary25.4
pancreas17.9
placenta29.5
prostate27.8
salivary gland14.4
skin2.8
small intestine38.9
spleen17.2
stomach18.9
testis18.5
thyroid gland17.8
urinary bladder17.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606366, gene) Ras homolog gene family, member u; RHOUOMIM


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