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> Protein (NX_Q7L273)
Protein (NX_Q7L273)
Protein
Gene SymbolKCTD9 to neXtProt (NX_Q7L273)
DescriptionBTB/POZ domain-containing protein KCTD9
Chromosome8
Location8p21.2 (25285366 ~ 25315992) to Ensembl
Sequene Features : Isoforms 1, Variants 37, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein homooligomerization .N/A .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 37 2
2014-09-19protein level
1 26 2
2014-05-27protein level
1 26 2
2014-02-25protein level
1 26 2
2013-12-09protein level
1 25 2
2013-11-01protein level
1 23 2
2013-09-12protein level
1 23 2
2013-08-17protein level
1 23 2
2013-07-15protein level
1 13 1
2013-06-11protein level
1 13 1
2013-02-12protein level
1 4 0
2012-12-20protein level
1 4 0
2012-10-30protein level
1 3 0
2012-10-07protein level
1 3 0
2012-08-24protein level
1 2 0
2012-07-28protein level
1 2 0
2012-06-08protein level
1 3 0
2012-05-07protein level
1 3 0
2012-04-10protein level
1 3 0
2012-01-13protein level
1 2 0
2011-12-20protein level
1 2 0
2011-11-11protein level
1 2 0
2011-08-23transcript level
1 2 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q7L273-1
20 0 0 42539.456
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-4397613,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-4397613,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
3 EBI-4397613,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
4 EBI-4397613,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
5 EBI-4397613,EBI-745213 AQP1  
  .cation transmembrane transport
.maintenance of symbiont-containing vacuole by host
.ammonium transmembrane transport
  + 60 more...
.carbon dioxide transmembrane transporter activity
.nitric oxide transmembrane transporter activity
.transmembrane transporter activity
  + 8 more...
.extracellular exosome
.apical part of cell
.axon terminus
  + 12 more...
6 EBI-4397613,EBI-359335 PSMB2  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 25 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.membrane
.proteasome core complex
  + 5 more...
7 EBI-4397613,EBI-744104 GEM  
  .metaphase plate congression
.chromosome organization
.metabolic process
  + 5 more...
.GDP binding
.GTP binding
.GTPase activity
.magnesium ion binding
.mitotic spindle
.spindle midzone
.midbody
  + 2 more...
8 EBI-4397613,EBI-307486 SKP1  
  .regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
.innate immune response
  + 11 more...
.ubiquitin-protein transferase activity .extracellular exosome
.Cul7-RING ubiquitin ligase complex
.SCF ubiquitin ligase complex
  + 2 more...
9 EBI-4397613,EBI-520375 CRADD  
  .positive regulation of apoptotic signaling pathway
.cellular response to mechanical stimulus
.extrinsic apoptotic signaling pathway via death domain receptors
  + 2 more...
.death domain binding
.protein binding, bridging
.protease binding
.cytoplasm
.nucleus
10 EBI-4397613,EBI-2339219 EHHADH  
  .fatty acid beta-oxidation
.internal protein amino acid acetylation
.coenzyme binding
.enzyme binding
.receptor binding
  + 3 more...
.cytosol
.peroxisome
.mitochondrion
11 EBI-4397613,EBI-742790 TRIM32  
  .positive regulation of cell motility
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.negative regulation of viral release from host cell
  + 21 more...
.ubiquitin protein ligase activity
.protein self-association
.ubiquitin binding
  + 8 more...
.striated muscle myosin thick filament
.cytosol
.cytoplasm
.nucleus
12 EBI-4397613,EBI-456129 CUL3  
  .intrinsic apoptotic signaling pathway
.negative regulation of canonical Wnt signaling pathway
.COPII vesicle coating
  + 22 more...
.POZ domain binding .extracellular exosome
.Cul3-RING ubiquitin ligase complex
.membrane
  + 4 more...
13 EBI-4397613,EBI-2341787 LONRF1  
  .N/A .zinc ion binding
.ATP-dependent peptidase activity
.N/A
14 EBI-4397613,EBI-10246152 SYT6  
  .acrosomal vesicle exocytosis
.calcium ion-dependent exocytosis of neurotransmitter
.regulation of calcium ion-dependent exocytosis
  + 2 more...
.protein homodimerization activity
.clathrin binding
.syntaxin binding
.calcium ion binding
.perinuclear endoplasmic reticulum
.synaptic vesicle membrane
.cell junction
  + 4 more...
15 EBI-4397613,EBI-10172380 FAM208B  
  .N/A .N/A .cytoplasm
.nucleoplasm
.nucleus
16 EBI-4397613,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
17 EBI-4397613,EBI-2557469 PPP1R18  
  .N/A .N/A .cytoskeleton
.cytoplasm
18 EBI-4397613,EBI-746368 PNKD  
  .neuromuscular process controlling posture
.regulation of dopamine metabolic process
.regulation of synaptic transmission, dopaminergic
.glutathione biosynthetic process
.zinc ion binding
.hydroxyacylglutathione hydrolase activity
.membrane
.mitochondrion
.nucleus
19 EBI-4397613,EBI-9050429 NUP35  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 17 more...
.N/A .intermediate filament cytoskeleton
.intracellular membrane-bounded organelle
.nuclear membrane
  + 4 more...
20 EBI-4397613,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
21 EBI-4397613,EBI-10293968 PPP1R16B  
  .positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
.negative regulation of peptidyl-serine dephosphorylation
.establishment of endothelial barrier
  + 6 more...
.protein phosphatase type 1 regulator activity .perinuclear region of cytoplasm
.cell projection
.plasma membrane
.nucleus
22 EBI-4397613,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
23 EBI-4397613,EBI-741626 FAM124B  
  .N/A .N/A .N/A
24 EBI-4397613,EBI-739467 GORASP2  
  .organelle organization
.mitotic cell cycle
.N/A .membrane
.Golgi apparatus
.Golgi membrane
25 EBI-4397613,EBI-712912 CBX8  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 3 more...
.methylated histone binding
.ubiquitin-protein transferase activity
.single-stranded RNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 3 more...
26 EBI-4397613,EBI-77889 MAD2L2  
  .negative regulation of transcription regulatory region DNA binding
.negative regulation of cell-cell adhesion mediated by cadherin
.negative regulation of canonical Wnt signaling pathway
  + 19 more...
.JUN kinase binding
.RNA polymerase II activating transcription factor binding
.zeta DNA polymerase complex
.spindle
.cytoplasm
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites25
bladder66
blood8
brain1
connective tissue13
embryonic tissue23
intestine12
kidney23
liver4
lung2
lymph node22
pharynx24
placenta7
prostate5
skin14
stomach10
testis18
uterus8
Health State
TissuesTPM*
normal8
adrenal tumor158
bladder carcinoma113
breast (mammary gland) tumor10
cervical tumor28
chondrosarcoma60
colorectal tumor8
esophageal tumor57
gastrointestinal tumor16
germ cell tumor15
non-neoplasia10
ovarian tumor13
primitive neuroectodermal tumor of the CNS15
skin tumor15
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult22
embryoid body42
blastocyst16
neonate32
fetus12
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.3
adrenal gland7.6
appendix9.4
bone marrow12
cerebral cortex3.2
colon18.1
duodenum16.8
esophagus18.6
gallbladder12.7
heart muscle21.7
kidney8.4
liver4.3
lung11
lymph node9.7
ovary10.7
pancreas3.2
placenta7.1
prostate13.5
salivary gland10.2
skin12.3
small intestine14
spleen7.5
stomach10.2
testis12
thyroid gland11.5
urinary bladder9.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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2014-2019 (C) Yonsei Proteome Research Center