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> Protein (NX_Q7L590)
Protein (NX_Q7L590)
Protein
Gene SymbolMCM10 to neXtProt (NX_Q7L590)
DescriptionProtein MCM10 homolog
Chromosome10
Location10p13 (13203554 ~ 13253104) to Ensembl
Sequene Features : Isoforms 2, Variants 128, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell proliferation
.DNA replication initiation
.DNA replication
  + 2 more...
.metal ion binding
.identical protein binding
.single-stranded DNA binding
  + 2 more...
.replication fork protection complex
.cytoplasm
.nucleolus
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 128 5
2014-09-19protein level
2 106 5
2014-05-27protein level
2 105 5
2014-02-25protein level
2 105 5
2013-12-09protein level
2 78 5
2013-11-01protein level
2 75 5
2013-09-12protein level
2 75 5
2013-08-17protein level
2 75 5
2013-07-15protein level
2 56 4
2013-06-11protein level
2 56 4
2013-02-12protein level
2 34 8
2012-12-20protein level
2 29 8
2012-10-30protein level
2 44 8
2012-10-07protein level
2 44 4
2012-08-24protein level
2 43 4
2012-07-28protein level
2 43 4
2012-06-08protein level
2 44 4
2012-05-07protein level
2 36 4
2012-04-10protein level
2 36 4
2012-01-13protein level
2 19 4
2011-12-20protein level
2 19 4
2011-11-11protein level
2 19 3
2011-08-23protein level
2 19 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q7L590-1
0 39 0 98121.1513
NX_Q7L590-2
0 39 0 98022.0832
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10233517,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
2 EBI-374912,EBI-374957 ORC2  
  .DNA replication initiation
.DNA replication
.mitotic cell cycle
  + 2 more...
.DNA replication origin binding .membrane
.plasma membrane
.centrosome
  + 6 more...
3 EBI-10233517,EBI-374900 MCM6  
  .DNA strand elongation involved in DNA replication
.DNA replication initiation
.DNA unwinding involved in DNA replication
  + 3 more...
.identical protein binding
.ATP binding
.single-stranded DNA binding
.DNA helicase activity
.MCM complex
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites100
blood40
bone55
bone marrow20
brain8
cervix20
embryonic tissue56
eye4
heart11
intestine12
kidney14
larynx42
liver29
lymph112
lymph node11
mammary gland39
placenta17
prostate15
salivary gland148
skin18
testis6
thymus25
uterus4
vascular19
Health State
TissuesTPM*
normal12
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma36
colorectal tumor17
gastrointestinal tumor33
germ cell tumor49
glioma18
head and neck tumor7
kidney tumor14
leukemia31
liver tumor31
lymphoma83
primitive neuroectodermal tumor of the CNS47
prostate cancer28
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult14
embryoid body57
blastocyst97
neonate32
fetus17
infant127
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix3.7
bone marrow6.6
colon1.9
duodenum1.3
esophagus1.8
lymph node5.1
placenta2.6
small intestine1.1
spleen1
stomach1.2
testis2
urinary bladder1.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609357, gene) Minichromosome maintenance 10, s. cerevisiae, homolog of; MCM10OMIM


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