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> Protein (NX_Q7L9L4)
Protein (NX_Q7L9L4)
Protein
Gene SymbolMOB1B to neXtProt (NX_Q7L9L4)
DescriptionMOB kinase activator 1B
Chromosome4
Location4q13.3 (71768043 ~ 71888166) to Ensembl
Sequene Features : Isoforms 2, Variants 8, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein autophosphorylation
.positive regulation of phosphorylation
.hippo signaling
.metal ion binding
.kinase binding
.kinase activator activity
.extracellular exosome
.cytosol
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 8 6
2014-09-19protein level
2 19 6
2014-05-27protein level
2 19 11
2014-02-25protein level
2 19 11
2013-12-09protein level
2 13 11
2013-11-01protein level
2 12 9
2013-09-12protein level
2 12 9
2013-08-17protein level
2 12 9
2013-07-15protein level
2 7 4
2013-06-11protein level
2 7 4
2013-02-12protein level
2 6 6
2012-12-20protein level
1 6 4
2012-10-30protein level
1 6 4
2012-10-07protein level
1 6 4
2012-08-24protein level
1 6 4
2012-07-28protein level
1 6 4
2012-06-08protein level
1 6 4
2012-05-07protein level
1 2 4
2012-04-10protein level
1 2 4
2012-01-13protein level
1 0 4
2011-12-20protein level
1 0 4
2011-11-11protein level
1 0 4
2011-08-23protein level
1 0 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q7L9L4-1
1 2 6 25074.5685
NX_Q7L9L4-2
1 2 6 25482.6762
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2558745,EBI-444209 LATS1  
  .negative regulation of canonical Wnt signaling pathway
.cell division
.cytoplasmic sequestering of protein
  + 11 more...
.protein kinase binding
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.cytosol
.microtubule organizing center
.spindle pole
2 EBI-2558745,EBI-742084 NT5C2  
  .nucleobase-containing small molecule metabolic process
.adenosine metabolic process
.IMP metabolic process
  + 6 more...
.nucleoside phosphotransferase activity
.metal ion binding
.5'-nucleotidase activity
.nucleotide binding
.cytosol
3 EBI-2558745,EBI-367376 STK4  
  .positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.hepatocyte apoptotic process
.negative regulation of canonical Wnt signaling pathway
  + 25 more...
.protein dimerization activity
.protein serine/threonine kinase activator activity
.protein homodimerization activity
  + 6 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
4 EBI-2558745,EBI-357849 TNIP1  
  .modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of inflammatory response
  + 9 more...
.mitogen-activated protein kinase binding .cytoplasm
.nucleus
.intracellular
5 EBI-2558745,EBI-3506895 LATS2  
  .negative regulation of canonical Wnt signaling pathway
.cell division
.regulation of organ growth
  + 9 more...
.metal ion binding
.ATP binding
.protein serine/threonine kinase activity
.cytosol
.microtubule organizing center
.cytoplasm
  + 2 more...
6 EBI-2558745,EBI-712969 CCDC53  
  .protein transport .N/A .WASH complex
.intracellular membrane-bounded organelle
.actin cytoskeleton
.early endosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
bladder33
blood8
bone marrow20
brain32
connective tissue13
ear62
embryonic tissue42
eye19
heart22
kidney71
liver19
lung8
lymph node122
mammary gland26
mouth15
muscle37
ovary49
pancreas70
placenta10
prostate10
skin18
thymus62
uterus43
Health State
TissuesTPM*
normal30
breast (mammary gland) tumor21
germ cell tumor18
glioma55
head and neck tumor7
kidney tumor43
leukemia10
liver tumor10
lymphoma13
non-neoplasia20
ovarian tumor52
prostate cancer9
skin tumor31
soft tissue/muscle tissue tumor63
uterine tumor33
Developmental Stage
TissuesTPM*
adult17
embryoid body42
blastocyst65
fetus41
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.5
adrenal gland8.7
appendix11.2
bone marrow20
cerebral cortex11.2
colon6.6
duodenum4.4
esophagus8.2
gallbladder8.3
heart muscle7.2
kidney22.8
liver4.1
lung10.7
lymph node12.2
ovary8.4
pancreas4.5
placenta7.1
prostate10.2
salivary gland6.7
skin8.1
small intestine5.7
spleen8.2
stomach8.6
testis7.3
thyroid gland12.4
urinary bladder8.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609282, gene) Mob1-like protein 1a; MOBKL1AOMIM


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