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> Protein (NX_Q7Z2X4)
Protein (NX_Q7Z2X4)
Protein
Gene SymbolPID1 to neXtProt (NX_Q7Z2X4)
DescriptionPTB-containing, cubilin and LRP1-interacting protein
Chromosome2
Location2q36.3 (229715242 ~ 230136001) to Ensembl
Sequene Features : Isoforms 4, Variants 50, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of glucose import in response to insulin stimulus
.positive regulation of ATP biosynthetic process
.negative regulation of ATP biosynthetic process
  + 19 more...
.N/A .cytoplasm
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 50 2
2014-09-19protein level
4 26 2
2014-05-27protein level
4 26 2
2014-02-25protein level
4 25 2
2013-12-09protein level
4 21 2
2013-11-01protein level
4 19 2
2013-09-12protein level
4 19 2
2013-08-17protein level
4 19 2
2013-07-15protein level
4 11 2
2013-06-11protein level
4 11 2
2013-02-12protein level
4 7 8
2012-12-20protein level
4 8 8
2012-10-30protein level
4 7 8
2012-10-07protein level
4 7 2
2012-08-24protein level
4 4 2
2012-07-28protein level
4 4 2
2012-06-08protein level
4 4 2
2012-05-07protein level
4 4 2
2012-04-10protein level
4 4 2
2012-01-13protein level
4 3 2
2011-12-20protein level
4 3 2
2011-11-11protein level
4 3 2
2011-08-23protein level
4 3 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q7Z2X4-1
2 8 0 28252.9884
NX_Q7Z2X4-2
2 8 0 28102.7292
NX_Q7Z2X4-3
1 8 0 19272.2613
NX_Q7Z2X4-4
1 9 0 24813.1989
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10256685,EBI-748171 CRX  
  .retina development in camera-type eye
.response to stimulus
.positive regulation of photoreceptor cell differentiation
  + 5 more...
.leucine zipper domain binding
.nuclear hormone receptor binding
.sequence-specific DNA binding transcription factor activity
  + 3 more...
.transcription factor complex
.nucleus
2 EBI-10256685,EBI-741141 NME1  
  .cellular response to fatty acid
.cellular response to glucose stimulus
.nucleobase-containing small molecule metabolic process
  + 22 more...
.poly(A) RNA binding
.ribosomal small subunit binding
.identical protein binding
  + 7 more...
.extracellular exosome
.perinuclear region of cytoplasm
.ruffle membrane
  + 7 more...
3 EBI-10256685,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
4 EBI-10256685,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
5 EBI-10256685,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
6 EBI-10256685,EBI-744695 BANP  
  .negative regulation of protein catabolic process
.protein localization to nucleus
.chromatin modification
  + 4 more...
.DNA binding .nucleoplasm
7 EBI-10256685,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
8 EBI-10256685,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
9 EBI-10256685,EBI-349832 GOPC  
  .protein homooligomerization
.regulation of catalytic activity
.apical protein localization
  + 6 more...
.ion channel binding .postsynaptic membrane
.protein complex
.Golgi-associated vesicle membrane
  + 9 more...
10 EBI-10256685,EBI-741515 THAP1  
  .regulation of mitotic cell cycle
.cell cycle
.regulation of transcription, DNA-templated
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.zinc ion binding
.PML body
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
blood16
bone13
brain54
connective tissue46
embryonic tissue9
eye28
heart89
intestine38
kidney18
larynx42
liver19
lung17
lymph node11
mouth45
ovary19
pancreas37
pharynx24
placenta56
prostate21
skin4
spleen56
stomach10
testis4
trachea38
uterus25
Health State
TissuesTPM*
normal40
chondrosarcoma84
colorectal tumor8
gastrointestinal tumor8
germ cell tumor3
glioma65
head and neck tumor14
kidney tumor29
leukemia21
liver tumor20
lung tumor19
non-neoplasia10
pancreatic tumor28
Developmental Stage
TissuesTPM*
adult25
blastocyst16
neonate32
fetus102
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue19.1
adrenal gland30.2
appendix14
cerebral cortex38.4
colon25.1
duodenum5.7
esophagus14.5
gallbladder16.9
heart muscle9.3
kidney6
liver34.5
lung26.4
lymph node5
ovary34.2
pancreas7.7
placenta27.3
prostate15.4
salivary gland3.6
skin5.2
small intestine16.7
spleen20.6
stomach8.1
testis7.8
thyroid gland4.8
urinary bladder19.4
Tissues
TissuesExpression level
appendixLow
bone marrowMedium
cerebral cortexMedium
colonHigh
duodenumHigh
endometrium 1Medium
epididymisMedium
fallopian tubeLow
heart muscleHigh
kidneyMedium
liverHigh
lungMedium
ovaryMedium
pancreasLow
placentaHigh
prostateLow
skeletal muscleLow
skin 1Medium
skin 2Low
small intestineMedium
soft tissue 1Medium
soft tissue 2Medium
stomach 1Low
testisMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*612930, gene) Phosphotyrosine interaction domain-containing 1; PID1OMIM


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