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> Protein (NX_Q7Z3K3)
Protein (NX_Q7Z3K3)
Protein
Gene SymbolPOGZ to neXtProt (NX_Q7Z3K3)
DescriptionPogo transposable element with ZNF domain
Chromosome1
Location1q21.3 (151375200 ~ 151431941) to Ensembl
Sequene Features : Isoforms 7, Variants 145, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.kinetochore assembly
.cell division
.mitotic sister chromatid cohesion
.metal ion binding
.DNA binding
.cytoplasm
.nucleoplasm
.nucleus
.nuclear chromatin
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
7 145 12
2014-09-19protein level
7 102 12
2014-05-27protein level
7 102 12
2014-02-25protein level
7 101 12
2013-12-09protein level
7 79 12
2013-11-01protein level
7 74 12
2013-09-12protein level
7 74 12
2013-08-17protein level
7 74 12
2013-07-15protein level
5 45 12
2013-06-11protein level
5 45 12
2013-02-12protein level
5 22 69
2012-12-20protein level
5 22 69
2012-10-30protein level
5 26 69
2012-10-07protein level
5 26 16
2012-08-24protein level
5 13 16
2012-07-28protein level
5 13 16
2012-06-08protein level
5 25 16
2012-05-07protein level
5 25 16
2012-04-10protein level
5 25 16
2012-01-13protein level
5 19 16
2011-12-20protein level
5 19 16
2011-11-11protein level
5 19 14
2011-08-23protein level
5 19 14
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q7Z3K3-1
0 55 0 155244.4717
NX_Q7Z3K3-2
0 54 0 150033.8062
NX_Q7Z3K3-3
1 53 0 151116.3108
NX_Q7Z3K3-4
0 11 0 37858.2129
NX_Q7Z3K3-5
1 53 0 145202.1134
NX_Q7Z3K3-6
0 55 0 154393.0562
NX_Q7Z3K3-7
0 54 0 149182.3907
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1389308,EBI-740220 HGS  
  .positive regulation of exosomal secretion
.protein localization to membrane
.membrane organization
  + 13 more...
.metal ion binding
.protein domain specific binding
.extracellular exosome
.intracellular membrane-bounded organelle
.multivesicular body membrane
  + 6 more...
2 EBI-1389308,EBI-744471 ZBTB24  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.hematopoietic progenitor cell differentiation
.metal ion binding
.DNA binding
.nucleus
3 EBI-1389308,EBI-7875264 DAB1  
  .lateral motor column neuron migration
.Golgi localization
.negative regulation of axonogenesis
  + 15 more...
.N/A .perinuclear region of cytoplasm
.apical part of cell
.neuronal cell body
  + 5 more...
4 EBI-1389308,EBI-298336 SP1  
  .definitive hemopoiesis
.embryonic process involved in female pregnancy
.embryonic skeletal system development
  + 19 more...
.HMG box domain binding
.metal ion binding
.transcription regulatory region DNA binding
  + 16 more...
.protein-DNA complex
.cytoplasm
.nucleoplasm
.nucleus
5 EBI-1389308,EBI-624770 POU2F1  
  .lens induction in camera-type eye
.negative regulation of transcription, DNA-templated
.olfactory placode formation
  + 2 more...
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.intracellular membrane-bounded organelle
.transcription factor complex
.nucleoplasm
.nucleus
6 EBI-1389308,EBI-389739 NFYA  
  .positive regulation of stem cell proliferation
.regulation of stem cell maintenance
.rhythmic process
  + 5 more...
.sequence-specific DNA binding transcription factor activity
.DNA binding
.core promoter sequence-specific DNA binding
.protein-DNA complex
.CCAAT-binding factor complex
.nucleoplasm
.nucleus
7 EBI-1389308,EBI-78219 CBX5  
  .negative regulation of transcription, DNA-templated
.viral process
.blood coagulation
.repressing transcription factor binding
.methylated histone binding
.protein binding, bridging
.chromatin binding
.histone methyltransferase complex
.nuclear pericentric heterochromatin
.transcriptional repressor complex
  + 8 more...
8 EBI-1389308,EBI-10172814 PRR20C  
  .N/A .N/A .N/A
9 EBI-1389308,EBI-618165 GABPB1  
  .positive regulation of transcription from RNA polymerase II promoter
.mitochondrion organization
.organelle organization
  + 2 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.sequence-specific DNA binding transcription factor activity
.nucleoplasm
.nucleus
10 EBI-1389308,EBI-724310 DAZAP2  
  .N/A .WW domain binding .cytoplasm
.nucleus
11 EBI-1389308,EBI-2547810 NRF1  
  .response to electrical stimulus
.response to folic acid
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.extracellular exosome
.cytoplasm
.nucleoplasm
12 EBI-1389308,EBI-744695 BANP  
  .negative regulation of protein catabolic process
.protein localization to nucleus
.chromatin modification
  + 4 more...
.DNA binding .nucleoplasm
13 EBI-1389308,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland30
ascites75
blood40
bone111
brain75
cervix41
connective tissue26
ear186
embryonic tissue75
eye52
heart78
intestine81
kidney28
liver24
lung77
lymph node200
mammary gland72
mouth45
muscle75
nerve128
ovary78
pancreas79
parathyroid48
pharynx73
pituitary gland242
placenta45
prostate58
skin33
spleen18
stomach20
testis64
thymus37
thyroid42
trachea38
uterus90
vascular19
Health State
TissuesTPM*
normal69
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor85
cervical tumor57
chondrosarcoma60
colorectal tumor97
gastrointestinal tumor33
germ cell tumor34
glioma65
head and neck tumor52
kidney tumor29
leukemia74
liver tumor31
lung tumor9
lymphoma13
non-neoplasia31
ovarian tumor118
pancreatic tumor57
primitive neuroectodermal tumor of the CNS23
prostate cancer86
skin tumor39
soft tissue/muscle tissue tumor47
uterine tumor66
Developmental Stage
TissuesTPM*
adult67
embryoid body85
blastocyst97
fetus107
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16.4
adrenal gland28.3
appendix19.6
bone marrow28.9
cerebral cortex24.8
colon18.5
duodenum15.7
esophagus15.5
gallbladder22.9
heart muscle16.8
kidney19.4
liver11.8
lung24.7
lymph node24.4
ovary48.2
pancreas10.9
placenta19.1
prostate23.3
salivary gland17
skin47.2
small intestine15.1
spleen28.2
stomach20.4
testis33.2
thyroid gland35.2
urinary bladder17.6
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyMedium
lateral ventricleHigh
liverMedium
lungHigh
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasLow
parathyroid glandMedium
placentaHigh
prostateLow
rectumHigh
salivary glandHigh
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2High
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*614787, gene) Pogo transposable element with znf domain; POGZOMIM


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