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> Protein (NX_Q7Z3S9)
Protein (NX_Q7Z3S9)
Protein
Gene SymbolNOTCH2NL to neXtProt (NX_Q7Z3S9)
DescriptionNotch homolog 2 N-terminal-like protein
Chromosome1
Location1q21.1 (145209119 ~ 145291972) to Ensembl
Sequene Features : Isoforms 3, Variants 46, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 46 16
2014-09-19protein level
3 34 16
2014-05-27protein level
3 34 16
2014-02-25protein level
3 34 16
2013-12-09protein level
3 36 16
2013-11-01protein level
3 34 16
2013-09-12protein level
3 34 16
2013-08-17protein level
3 34 16
2013-07-15protein level
3 27 16
2013-06-11protein level
3 27 16
2013-02-12protein level
3 17 48
2012-12-20protein level
3 17 48
2012-10-30protein level
3 17 48
2012-10-07protein level
3 17 16
2012-08-24protein level
3 15 16
2012-07-28protein level
3 15 16
2012-06-08protein level
3 5 16
2012-05-07protein level
3 5 16
2012-04-10protein level
3 5 16
2012-01-13protein level
3 5 16
2011-12-20protein level
3 5 16
2011-11-11protein level
3 5 16
2011-08-23protein level
3 5 16
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q7Z3S9-1
0 3 6 25816.848
NX_Q7Z3S9-2
1 2 6 24929.524
NX_Q7Z3S9-3
0 2 7 27270.3868
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-945833,EBI-10171756 SLC22A23  
  .ion transport .transmembrane transporter activity .integral component of membrane
2 EBI-945833,EBI-10173491 CLEC18A  
  .N/A .carbohydrate binding .extracellular region
3 EBI-945833,EBI-10173955 C5orf60  
  .N/A .N/A .integral component of membrane
4 EBI-945833,EBI-1389829 FAAH  
  .fatty acid catabolic process .acylglycerol lipase activity
.fatty acid amide hydrolase activity
.carbon-nitrogen ligase activity, with glutamine as amido-N-donor
.organelle membrane
.integral component of membrane
.endomembrane system
  + 2 more...
5 EBI-945833,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
6 EBI-945833,EBI-744352 GABRD  
  .synaptic transmission
.signal transduction
.transport
.chloride channel activity
.extracellular ligand-gated ion channel activity
.GABA-A receptor activity
.postsynaptic membrane
.chloride channel complex
.cell junction
.integral component of plasma membrane
7 EBI-945833,EBI-8652667 TSPAN4  
  .protein complex assembly .integrin binding
.antigen binding
.vesicle
.integral component of membrane
.focal adhesion
.plasma membrane
8 EBI-945833,EBI-2513988 LIN7A  
  .protein localization to basolateral plasma membrane
.inner ear development
.synaptic vesicle transport
  + 7 more...
.L27 domain binding .MPP7-DLG1-LIN7 complex
.extracellular exosome
.postsynaptic membrane
  + 7 more...
9 EBI-945833,EBI-10182490 EPHB6  
  .ephrin receptor signaling pathway
.axon guidance
.ATP binding
.ephrin receptor activity
.receptor activity
.integral component of plasma membrane
.plasma membrane
.cytosol
.extracellular region
10 EBI-945833,EBI-712355 RGL2  
  .positive regulation of GTPase activity
.Ras protein signal transduction
.Ras guanyl-nucleotide exchange factor activity .intracellular
11 EBI-945833,EBI-6262458 MATN3  
  .extracellular matrix organization
.skeletal system development
.extracellular matrix structural constituent .proteinaceous extracellular matrix
.extracellular region
12 EBI-945833,EBI-725515 FRS3  
  .fibroblast growth factor receptor signaling pathway
.signal transduction
.fibroblast growth factor receptor binding .plasma membrane
13 EBI-945833,EBI-3866665 SPRY1  
  .negative regulation of ERK1 and ERK2 cascade
.bud elongation involved in lung branching
.negative regulation of neurotrophin TRK receptor signaling pathway
  + 10 more...
.N/A .plasma membrane
.cytosol
14 EBI-945833,EBI-722017 PPAP2C  
  .small molecule metabolic process
.sphingolipid biosynthetic process
.dephosphorylation
.sphingolipid metabolic process
.phosphatidate phosphatase activity
.phosphoprotein phosphatase activity
.integral component of membrane
.membrane
.plasma membrane
15 EBI-945833,EBI-3915857 KLK8  
  .synapse organization
.regulation of synapse organization
.neuron projection morphogenesis
  + 6 more...
.serine-type endopeptidase activity .cytoplasm
.extracellular space
16 EBI-945833,EBI-947402 MAPKBP1  
  .N/A .N/A .N/A
17 EBI-945833,EBI-398610 EIF4E2  
  .cytokine-mediated signaling pathway
.negative regulation of translation
.in utero embryonic development
.poly(A) RNA binding
.ubiquitin protein ligase binding
.translation factor activity, RNA binding
  + 2 more...
.mRNA cap binding complex
.cytosol
18 EBI-945833,EBI-720447 RAMP3  
  .positive regulation of establishment of protein localization to plasma membrane
.G-protein coupled receptor signaling pathway involved in heart process
.protein localization to plasma membrane
  + 8 more...
.coreceptor activity
.protein transporter activity
.receptor activity
.receptor complex
.cell surface
.integral component of plasma membrane
  + 3 more...
19 EBI-945833,EBI-718707 LRCH4  
  .nervous system development .N/A .PML body
20 EBI-945833,EBI-748664 HSBP1  
  .regulation of cellular response to heat
.endodermal cell differentiation
.cellular response to heat
  + 2 more...
.transcription corepressor activity .cytoskeleton
.nucleoplasm
.nucleus
21 EBI-945833,EBI-749295 STK16  
  .cellular response to transforming growth factor beta stimulus
.protein autophosphorylation
.regulation of signal transduction
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.protein serine/threonine kinase activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.perinuclear region of cytoplasm
.membrane
.Golgi-associated vesicle
.cytoplasm
22 EBI-945833,EBI-374781 GLRX3  
  .cell redox homeostasis
.negative regulation of cardiac muscle hypertrophy
.regulation of the force of heart contraction
.iron-sulfur cluster binding
.metal ion binding
.poly(A) RNA binding
  + 2 more...
.extracellular exosome
.Z disc
.cell cortex
23 EBI-945833,EBI-742764 PDE9A  
  .cGMP-mediated signaling
.metabolic process
.blood coagulation
.signal transduction
.3',5'-cyclic-GMP phosphodiesterase activity
.metal ion binding
.3',5'-cyclic-nucleotide phosphodiesterase activity
.perinuclear region of cytoplasm
.perikaryon
.ruffle membrane
  + 3 more...
24 EBI-945833,EBI-2513774 FARS2  
  .gene expression
.tRNA processing
.phenylalanyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.phenylalanine-tRNA ligase activity
.magnesium ion binding
.tRNA binding
.mitochondrial matrix
.mitochondrion
25 EBI-945833,EBI-1045459 SNAI1  
  .regulation of tight junction assembly
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.Notch signaling involved in heart development
  + 16 more...
.metal ion binding
.kinase binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.cytoplasm
.nucleus
26 EBI-945833,EBI-742362 DNAL4  
  .neurotrophin TRK receptor signaling pathway
.microtubule-based process
.motor activity .dynein complex
.cilium
.plasma membrane
  + 2 more...
27 EBI-945833,EBI-719843 HBZ  
  .erythrocyte maturation
.negative regulation of transcription from RNA polymerase II promoter
.heme binding
.oxygen binding
.iron ion binding
.oxygen transporter activity
.extracellular exosome
.hemoglobin complex
28 EBI-945833,EBI-353997 GNAI2  
  .regulation of calcium ion transport
.cell division
.negative regulation of synaptic transmission
  + 17 more...
.metal ion binding
.G-protein beta/gamma-subunit complex binding
.GTP binding
  + 3 more...
.extracellular exosome
.membrane raft
.vesicle
  + 8 more...
29 EBI-945833,EBI-300173 ITGB2  
  .positive regulation of NF-kappaB transcription factor activity
.leukocyte migration
.activated T cell proliferation
  + 26 more...
.cell adhesion molecule binding
.metal ion binding
.ICAM-3 receptor activity
  + 2 more...
.extracellular exosome
.membrane raft
.receptor complex
  + 6 more...
30 EBI-945833,EBI-9008836 CHRNG  
  .transmembrane transport
.regulation of membrane potential
.synaptic transmission
  + 3 more...
.acetylcholine receptor activity
.channel activity
.acetylcholine-activated cation-selective channel activity
.postsynaptic membrane
.cell junction
.acetylcholine-gated channel complex
  + 2 more...
31 EBI-945833,EBI-2480756 RET  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.lymphocyte migration into lymphoid organs
.positive regulation of metanephric glomerulus development
  + 30 more...
.ATP binding
.calcium ion binding
.receptor activity
  + 2 more...
.membrane raft
.receptor complex
.intracellular membrane-bounded organelle
  + 4 more...
32 EBI-945833,EBI-5462635 CTSG  
  .neutrophil mediated killing of gram-positive bacterium
.defense response to fungus
.positive regulation of immune response
  + 10 more...
.peptidase activity
.heparin binding
.serine-type endopeptidase activity
.extracellular exosome
.secretory granule
.cell surface
  + 4 more...
33 EBI-945833,EBI-10195914 MFI2  
  .negative regulation of substrate adhesion-dependent cell spreading
.iron ion import
.positive regulation of extracellular matrix disassembly
  + 2 more...
.iron ion binding .extracellular exosome
.anchored component of plasma membrane
.cell surface
  + 2 more...
34 EBI-945833,EBI-346340 HCK  
  .positive regulation of actin cytoskeleton reorganization
.regulation of podosome assembly
.cellular response to peptide hormone stimulus
  + 28 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.cell projection
.extrinsic component of cytoplasmic side of plasma membrane
.transport vesicle
  + 7 more...
35 EBI-945833,EBI-353467 GSTP1  
  .negative regulation of extrinsic apoptotic signaling pathway
.glutathione derivative biosynthetic process
.negative regulation of monocyte chemotactic protein-1 production
  + 27 more...
.nitric oxide binding
.dinitrosyl-iron complex binding
.S-nitrosoglutathione binding
  + 3 more...
.TRAF2-GSTP1 complex
.extracellular exosome
.vesicle
  + 7 more...
36 EBI-945833,EBI-8832659 CST2  
  .negative regulation of endopeptidase activity
.detection of chemical stimulus involved in sensory perception of bitter taste
.cysteine-type endopeptidase inhibitor activity .extracellular space
37 EBI-945833,EBI-2872294 CSF1  
  .positive regulation of glial cell migration
.positive regulation of macrophage colony-stimulating factor signaling pathway
.mammary duct terminal end bud growth
  + 33 more...
.protein homodimerization activity
.growth factor activity
.macrophage colony-stimulating factor receptor binding
.cytokine activity
.CSF1-CSF1R complex
.extracellular exosome
.perinuclear region of cytoplasm
  + 5 more...
38 EBI-945833,EBI-8588553 GIP  
  .triglyceride homeostasis
.positive regulation of glucagon secretion
.long-term synaptic potentiation
  + 22 more...
.hormone activity .neuronal cell body
.secretory granule lumen
.endoplasmic reticulum lumen
  + 2 more...
39 EBI-945833,EBI-1052631 ALPI  
  .dephosphorylation .zinc ion binding
.alkaline phosphatase activity
.protease binding
.magnesium ion binding
.anchored component of membrane
.integral component of membrane
.plasma membrane
40 EBI-945833,EBI-352528 HSPD1  
  .protein maturation
.chaperone-mediated protein complex assembly
.positive regulation of T cell activation
  + 21 more...
.chaperone binding
.unfolded protein binding
.poly(A) RNA binding
  + 8 more...
.extracellular exosome
.lipopolysaccharide receptor complex
.protein complex
  + 13 more...
41 EBI-945833,EBI-4290895 PRPS2  
  .organ regeneration
.AMP biosynthetic process
.nucleobase-containing compound metabolic process
.5-phosphoribose 1-diphosphate biosynthetic process
.ADP binding
.protein homodimerization activity
.identical protein binding
  + 7 more...
.extracellular exosome
.ribose phosphate diphosphokinase complex
42 EBI-945833,EBI-356254 SLC25A6  
  .regulation of insulin secretion
.active induction of host immune response by virus
.small molecule metabolic process
  + 9 more...
.ATP:ADP antiporter activity .integral component of membrane
.mitochondrial inner membrane presequence translocase complex
.mitochondrial inner membrane
  + 2 more...
43 EBI-945833,EBI-2868897 IFI30  
  .interferon-gamma-mediated signaling pathway
.protein stabilization
.negative regulation of fibroblast proliferation
  + 3 more...
.oxidoreductase activity, acting on a sulfur group of donors .intracellular membrane-bounded organelle
.lysosomal lumen
.cell junction
  + 4 more...
44 EBI-945833,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
45 EBI-945833,EBI-3919694 PVR  
  .susceptibility to T cell mediated cytotoxicity
.regulation of immune response
.positive regulation of natural killer cell mediated cytotoxicity
  + 7 more...
.cell adhesion molecule binding
.receptor activity
.extracellular exosome
.integral component of membrane
.cell surface
  + 4 more...
46 EBI-945833,EBI-747044 NPPB  
  .regulation of blood vessel size
.regulation of vascular permeability
.regulation of vasodilation
  + 9 more...
.diuretic hormone activity
.hormone activity
.receptor binding
.protein complex
.extracellular space
.extracellular region
47 EBI-945833,EBI-1965483 ZNF32  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
48 EBI-945833,EBI-10200479 SPINK2  
  .negative regulation of endopeptidase activity .serine-type endopeptidase inhibitor activity
.endopeptidase inhibitor activity
.extracellular region
49 EBI-945833,EBI-2806671 GATA2  
  .regulation of forebrain neuron differentiation
.negative regulation of neural precursor cell proliferation
.GABAergic neuron differentiation
  + 29 more...
.C2H2 zinc finger domain binding
.zinc ion binding
.transcription factor binding
  + 5 more...
.protein complex
.nucleoplasm
50 EBI-945833,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
51 EBI-945833,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
52 EBI-945833,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
53 EBI-945833,EBI-747133 COL8A1  
  .epithelial cell proliferation
.camera-type eye morphogenesis
.endodermal cell differentiation
  + 6 more...
.N/A .extracellular exosome
.intracellular membrane-bounded organelle
.endoplasmic reticulum lumen
  + 2 more...
54 EBI-945833,EBI-745213 AQP1  
  .cation transmembrane transport
.maintenance of symbiont-containing vacuole by host
.ammonium transmembrane transport
  + 60 more...
.carbon dioxide transmembrane transporter activity
.nitric oxide transmembrane transporter activity
.transmembrane transporter activity
  + 8 more...
.extracellular exosome
.apical part of cell
.axon terminus
  + 12 more...
55 EBI-945833,EBI-80475 IL2RG  
  .interleukin-7-mediated signaling pathway
.interleukin-2-mediated signaling pathway
.interleukin-4-mediated signaling pathway
  + 3 more...
.interleukin-2 binding
.cytokine receptor activity
.membrane
.external side of plasma membrane
.integral component of plasma membrane
.plasma membrane
56 EBI-945833,EBI-742094 KRT20  
  .regulation of protein secretion
.intermediate filament organization
.cellular response to stress
.apoptotic process
.structural constituent of cytoskeleton .intermediate filament
.cytoplasm
57 EBI-945833,EBI-749311 HPCAL1  
  .signal transduction .calcium ion binding .extracellular exosome
58 EBI-945833,EBI-7466542 GLP1R  
  .regulation of insulin secretion
.small molecule metabolic process
.cAMP-mediated signaling
  + 6 more...
.glucagon receptor activity
.transmembrane signaling receptor activity
.integral component of membrane
.plasma membrane
59 EBI-945833,EBI-2558314 ALDH3B1  
  .oxidation-reduction process
.aldehyde catabolic process
.cellular response to oxidative stress
  + 3 more...
.aldehyde dehydrogenase [NAD(P)+] activity
.3-chloroallyl aldehyde dehydrogenase activity
.extracellular exosome
.vesicle
.plasma membrane
  + 2 more...
60 EBI-945833,EBI-495538 FASLG  
  .positive regulation of endothelial cell apoptotic process
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.necroptotic signaling pathway
  + 30 more...
.receptor binding .extracellular exosome
.cytoplasmic membrane-bounded vesicle lumen
.perinuclear region of cytoplasm
  + 8 more...
61 EBI-945833,EBI-10210114 NPBWR2  
  .opioid receptor signaling pathway
.synaptic transmission
.neuropeptide signaling pathway
  + 2 more...
.neuropeptide binding
.neuropeptide receptor activity
.opioid receptor activity
.neuron projection
.integral component of membrane
.integral component of plasma membrane
.plasma membrane
62 EBI-945833,EBI-10210351 NMU  
  .positive regulation of synaptic transmission
.positive regulation of hormone secretion
.positive regulation of smooth muscle contraction
  + 9 more...
.receptor binding .terminal bouton
.extracellular region
63 EBI-945833,EBI-740785 HOXA1  
  .cochlea morphogenesis
.cochlea development
.cellular response to retinoic acid
  + 24 more...
.sequence-specific DNA binding .nucleus
64 EBI-945833,EBI-750494 SMCP  
  .sperm motility
.penetration of zona pellucida
.N/A .mitochondrial membrane
.mitochondrion
.cytoplasm
65 EBI-945833,EBI-10211940 MXI1  
  .cytoplasmic sequestering of transcription factor
.negative regulation of cell proliferation
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.transcription corepressor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
66 EBI-945833,EBI-722730 EFNA3  
  .ephrin receptor signaling pathway
.axon guidance
.cell-cell signaling
.ephrin receptor binding
.transmembrane-ephrin receptor activity
.anchored component of membrane
.integral component of plasma membrane
.plasma membrane
.extracellular region
67 EBI-945833,EBI-1383852 PRKAA2  
  .regulation of energy homeostasis
.membrane organization
.fatty acid homeostasis
  + 31 more...
.[acetyl-CoA carboxylase] kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
.metal ion binding
  + 7 more...
.AMP-activated protein kinase complex
.cytosol
.cytoplasm
.nucleoplasm
68 EBI-945833,EBI-744104 GEM  
  .metaphase plate congression
.chromosome organization
.metabolic process
  + 5 more...
.GDP binding
.GTP binding
.GTPase activity
.magnesium ion binding
.mitotic spindle
.spindle midzone
.midbody
  + 2 more...
69 EBI-945833,EBI-746103 AQP5  
  .transmembrane transport
.camera-type eye morphogenesis
.saliva secretion
  + 8 more...
.glycerol channel activity
.water channel activity
.extracellular exosome
.apical plasma membrane
.basal plasma membrane
  + 4 more...
70 EBI-945833,EBI-751440 CLDN2  
  .calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules .identical protein binding
.structural molecule activity
.extracellular exosome
.integral component of membrane
.tight junction
.plasma membrane
71 EBI-945833,EBI-10176379 KRTAP12-2  
  .N/A .N/A .keratin filament
72 EBI-945833,EBI-10176396 KRTAP12-4  
  .N/A .N/A .keratin filament
73 EBI-945833,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
74 EBI-945833,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
75 EBI-945833,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
76 EBI-945833,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
77 EBI-945833,EBI-10217483 KRTAP10-11  
  .N/A .N/A .keratin filament
78 EBI-945833,EBI-353027 RPS28  
  .cellular protein metabolic process
.ribosomal small subunit biogenesis
.viral transcription
  + 10 more...
.poly(A) RNA binding
.structural constituent of ribosome
.extracellular exosome
.cytosolic small ribosomal subunit
.small ribosomal subunit
  + 2 more...
79 EBI-945833,EBI-3895726 BLCAP  
  .apoptotic nuclear changes
.cell cycle
.N/A .integral component of membrane
80 EBI-945833,EBI-10221390 KRT83  
  .hair cycle
.epidermis development
.aging
.structural molecule activity .keratin filament
.extracellular space
81 EBI-945833,EBI-10221726 ADAMTSL3  
  .N/A .zinc ion binding
.metallopeptidase activity
.proteinaceous extracellular matrix
82 EBI-945833,EBI-10192698 CREB5  
  .adipose tissue development
.positive regulation of transcription, DNA-templated
.fat cell differentiation
.transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.extracellular exosome
.nucleus
83 EBI-945833,EBI-2115896 CD164  
  .hemopoiesis
.negative regulation of cell proliferation
.muscle organ development
  + 6 more...
.N/A .endosome membrane
.integral component of plasma membrane
.plasma membrane
  + 4 more...
84 EBI-945833,EBI-10223946 WT1-AS  
  .N/A .N/A .N/A
85 EBI-945833,EBI-603457 TNK2  
  .regulation of clathrin-mediated endocytosis
.positive regulation of peptidyl-tyrosine phosphorylation
.innate immune response
  + 10 more...
.hormone receptor binding
.WW domain binding
.metal ion binding
  + 8 more...
.Grb2-EGFR complex
.neuronal cell body
.extrinsic component of cytoplasmic side of plasma membrane
  + 12 more...
86 EBI-945833,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
87 EBI-945833,EBI-714236 MTA1  
  .negative regulation of nucleic acid-templated transcription
.positive regulation of protein autoubiquitination
.regulation of inflammatory response
  + 11 more...
.zinc ion binding
.transcription corepressor activity
.transcription coactivator activity
  + 5 more...
.intracellular membrane-bounded organelle
.NuRD complex
.microtubule
  + 4 more...
88 EBI-945833,EBI-10233928 ICAM4  
  .regulation of immune response
.extracellular matrix organization
.single organismal cell-cell adhesion
.cell adhesion
.integrin binding .integral component of membrane
.integral component of plasma membrane
.plasma membrane
  + 2 more...
89 EBI-945833,EBI-2510602 JOSD1  
  .N/A .omega peptidase activity .membrane
.plasma membrane
.cytoplasm
90 EBI-945833,EBI-8641936 NAB2  
  .regulation of epidermis development
.myelination
.negative regulation of transcription from RNA polymerase III promoter
  + 5 more...
.transcription corepressor activity .nucleus
91 EBI-945833,EBI-6426443 KLHL38  
  .N/A .N/A .N/A
92 EBI-945833,EBI-3923548 ADCK5  
  .N/A .protein serine/threonine kinase activity .integral component of membrane
.mitochondrion
93 EBI-945833,EBI-10241252 KRTAP13-3  
  .N/A .N/A .intermediate filament
94 EBI-945833,EBI-2690768 LONRF3  
  .N/A .zinc ion binding
.ATP-dependent peptidase activity
.N/A
95 EBI-945833,EBI-10243533 -  
  .N/A .N/A .N/A
96 EBI-945833,EBI-10245291 LCE3C  
  .keratinization .N/A .N/A
97 EBI-945833,EBI-10245456 LCE3E  
  .keratinization .N/A .N/A
98 EBI-945833,EBI-10245913 LCE1B  
  .keratinization .N/A .N/A
99 EBI-945833,EBI-10246750 LCE2D  
  .keratinization .N/A .N/A
100 EBI-945833,EBI-2806032 THEMIS2  
  .T cell receptor signaling pathway
.cell adhesion
.inflammatory response
.N/A .cytoplasm
.nucleus
101 EBI-945833,EBI-10247271 FAM74A6  
  .N/A .N/A .N/A
102 EBI-945833,EBI-744560 WDR25  
  .N/A .N/A .N/A
103 EBI-945833,EBI-715463 GLYAT  
  .small molecule metabolic process
.monocarboxylic acid metabolic process
.response to toxic substance
  + 3 more...
.glycine N-benzoyltransferase activity
.glycine N-acyltransferase activity
.transferase activity, transferring acyl groups
.extracellular exosome
.mitochondrial matrix
.mitochondrion
104 EBI-945833,EBI-10250562 KRTAP5-6  
  .N/A .N/A .keratin filament
105 EBI-945833,EBI-6660291 C11orf87  
  .N/A .N/A .integral component of membrane
106 EBI-945833,EBI-3957672 KRTAP26-1  
  .N/A .N/A .intermediate filament
107 EBI-945833,EBI-7910762 LRFN4  
  .N/A .N/A .integral component of membrane
108 EBI-945833,EBI-8635958 SPATA8  
  .N/A .N/A .N/A
109 EBI-945833,EBI-10254938 ADAMTSL5  
  .N/A .zinc ion binding
.heparin binding
.metalloendopeptidase activity
.proteinaceous extracellular matrix
.extracellular region
.microfibril
110 EBI-945833,EBI-8465456 C16orf59  
  .N/A .N/A .N/A
111 EBI-945833,EBI-10256685 PID1  
  .negative regulation of glucose import in response to insulin stimulus
.positive regulation of ATP biosynthetic process
.negative regulation of ATP biosynthetic process
  + 19 more...
.N/A .cytoplasm
.nucleoplasm
112 EBI-945833,EBI-727146 ATG9A  
  .innate immune response
.late nucleophagy
.piecemeal microautophagy of nucleus
  + 5 more...
.N/A .recycling endosome
.late endosome membrane
.cytoplasmic vesicle
  + 8 more...
113 EBI-945833,EBI-10257651 LIMS2  
  .positive regulation of integrin-mediated signaling pathway
.negative regulation of hepatocyte proliferation
.negative regulation of neural precursor cell proliferation
  + 4 more...
.zinc ion binding .focal adhesion
.plasma membrane
.cytosol
.nucleus
114 EBI-945833,EBI-2799342 TMEM150A  
  .regulation of autophagy
.catabolic process
.N/A .integral component of membrane
.plasma membrane
.lysosome
115 EBI-945833,EBI-10258951 RTN4RL1  
  .axon regeneration .receptor activity .extracellular exosome
.anchored component of plasma membrane
.membrane raft
  + 2 more...
116 EBI-945833,EBI-10261452 TBC1D10C  
  .negative regulation of ERK1 and ERK2 cascade
.negative regulation of NFAT protein import into nucleus
.negative regulation of B cell activation
.retrograde transport, endosome to Golgi
.GTPase activator activity .filopodium membrane
.membrane
.plasma membrane
117 EBI-945833,EBI-8650724 CARKD  
  .nicotinamide nucleotide metabolic process .ADP-dependent NAD(P)H-hydrate dehydratase activity
.ATP-dependent NAD(P)H-hydrate dehydratase activity
.ATP binding
.mitochondrion
118 EBI-945833,EBI-5235829 TRIM42  
  .N/A .zinc ion binding .intracellular
119 EBI-945833,EBI-726439 ZNF440  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
120 EBI-945833,EBI-10269044 POMGNT2  
  .protein O-linked mannosylation
.protein O-linked glycosylation
.neuron migration
.protein O-GlcNAc transferase activity
.acetylglucosaminyltransferase activity
.integral component of membrane
.endoplasmic reticulum membrane
.endoplasmic reticulum
121 EBI-945833,EBI-747580 ZNF439  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
122 EBI-945833,EBI-7127986 CHDH  
  .glycine betaine biosynthetic process from choline .flavin adenine dinucleotide binding
.choline dehydrogenase activity
.mitochondrial inner membrane
123 EBI-945833,EBI-744545 CATSPER1  
  .membrane depolarization during action potential
.calcium ion import
.regulation of cilium beat frequency involved in ciliary motility
  + 9 more...
.voltage-gated calcium channel activity
.calcium activated cation channel activity
.CatSper complex
.motile cilium
.plasma membrane
124 EBI-945833,EBI-752049 FAM71C  
  .N/A .N/A .N/A
125 EBI-945833,EBI-10271580 CCDC26  
  .N/A .N/A .N/A
126 EBI-945833,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
127 EBI-945833,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
128 EBI-945833,EBI-743796 RAB3IL1  
  .positive regulation of GTPase activity
.protein transport
.Rab guanyl-nucleotide exchange factor activity .N/A
129 EBI-945833,EBI-746041 CCER1  
  .N/A .N/A .N/A
130 EBI-945833,EBI-10274247 CERK  
  .lipid phosphorylation
.small molecule metabolic process
.protein kinase C-activating G-protein coupled receptor signaling pathway
  + 3 more...
.ATP binding
.diacylglycerol kinase activity
.NAD+ kinase activity
  + 2 more...
.integral component of membrane
.plasma membrane
.mitochondrion
131 EBI-945833,EBI-7199479 PTPMT1  
  .inositol phosphate dephosphorylation
.glycerophospholipid biosynthetic process
.small molecule metabolic process
  + 4 more...
.phosphatidylglycerophosphatase activity
.protein tyrosine/serine/threonine phosphatase activity
.protein tyrosine phosphatase activity
.phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
.integral component of mitochondrial inner membrane
.mitochondrion
.nucleus
132 EBI-945833,EBI-10277687 SELM  
  .N/A .N/A .perinuclear region of cytoplasm
.Golgi apparatus
.endoplasmic reticulum
  + 2 more...
133 EBI-945833,EBI-448771 DOCK2  
  .positive regulation of phagocytosis
.regulation of defense response to virus by virus
.alpha-beta T cell proliferation
  + 12 more...
.T cell receptor binding
.Rac guanyl-nucleotide exchange factor activity
.extracellular exosome
.membrane
.endomembrane system
  + 2 more...
134 EBI-945833,EBI-718419 PVRL2  
  .susceptibility to T cell mediated cytotoxicity
.establishment of mitochondrion localization
.regulation of immune response
  + 22 more...
.cell adhesion molecule binding
.protein homodimerization activity
.identical protein binding
  + 2 more...
.extracellular exosome
.integral component of membrane
.cell surface
  + 4 more...
135 EBI-945833,EBI-751290 PCSK5  
  .embryonic skeletal system development
.embryonic digestive tract development
.neurotrophin TRK receptor signaling pathway
  + 15 more...
.peptide binding
.peptidase activity
.serine-type endopeptidase activity
.secretory granule
.integral component of membrane
.Golgi lumen
  + 2 more...
136 EBI-945833,EBI-1380477 INPP5D  
  .leukocyte migration
.T cell receptor signaling pathway
.negative regulation of immune response
  + 22 more...
.phosphatidylinositol trisphosphate phosphatase activity
.inositol-polyphosphate 5-phosphatase activity
.membrane
.cytosol
137 EBI-945833,EBI-455078 SMARCE1  
  .negative regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
.metabolic process
  + 4 more...
.protein N-terminus binding
.ligand-dependent nuclear receptor binding
.N-acetyltransferase activity
  + 4 more...
.nBAF complex
.npBAF complex
.protein complex
  + 6 more...
138 EBI-945833,EBI-741068 FBXW5  
  .centrosome duplication
.proteasome-mediated ubiquitin-dependent protein catabolic process
.SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  + 2 more...
.protein kinase binding .Cul4-RING E3 ubiquitin ligase complex
.SCF ubiquitin ligase complex
.cytoplasm
139 EBI-945833,EBI-723276 PSMG2  
  .proteasome assembly
.negative regulation of apoptotic process
.mitotic spindle assembly checkpoint
.N/A .nucleus
140 EBI-945833,EBI-10286106 LINC00526  
  .N/A .N/A .N/A
141 EBI-945833,EBI-3916242 ACY3  
  .small molecule metabolic process
.viral process
.xenobiotic metabolic process
.metal ion binding
.hydrolase activity, acting on ester bonds
.aminoacylase activity
.extracellular exosome
.apical plasma membrane
.cytosol
142 EBI-945833,EBI-1222622 PCED1B  
  .N/A .N/A .N/A
143 EBI-945833,EBI-10288884 TMEM41A  
  .N/A .N/A .integral component of membrane
144 EBI-945833,EBI-2509913 TNIP3  
  .cellular response to lipopolysaccharide
.negative regulation of I-kappaB kinase/NF-kappaB signaling
.toll-like receptor 4 signaling pathway
  + 2 more...
.polyubiquitin binding .N/A
145 EBI-945833,EBI-746300 DHRS1  
  .N/A .oxidoreductase activity .endoplasmic reticulum
.mitochondrial inner membrane
146 EBI-945833,EBI-10291310 HSPA12B  
  .N/A .ATP binding .N/A
147 EBI-945833,EBI-947779 RCHY1  
  .error-free translesion synthesis
.protein autoubiquitination
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 5 more...
.protein homodimerization activity
.ligase activity
.zinc ion binding
  + 2 more...
.nuclear speck
.cytoplasm
.nucleoplasm
  + 2 more...
148 EBI-945833,EBI-2908273 PIGS  
  .cellular protein metabolic process
.post-translational protein modification
.attachment of GPI anchor to protein
.C-terminal protein lipidation
.GPI-anchor transamidase activity .GPI-anchor transamidase complex
.membrane
.endoplasmic reticulum membrane
149 EBI-945833,EBI-715783 KCTD15  
  .protein homooligomerization
.multicellular organismal development
.N/A .N/A
150 EBI-945833,EBI-6427977 ZNF587  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
151 EBI-945833,EBI-2828248 P2RX4  
  .apoptotic signaling pathway
.cellular response to ATP
.regulation of excitatory postsynaptic membrane potential
  + 25 more...
.cadherin binding
.protein homodimerization activity
.zinc ion binding
  + 6 more...
.extracellular exosome
.perinuclear region of cytoplasm
.apical part of cell
  + 10 more...
152 EBI-945833,EBI-3916225 FOXB1  
  .cell migration in diencephalon
.inferior colliculus development
.mammary gland lobule development
  + 19 more...
.sequence-specific DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
153 EBI-945833,EBI-5458244 ARID3A  
  .N/A .chromatin binding
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II regulatory region sequence-specific DNA binding
.membrane raft
.Golgi apparatus
.cytoplasm
  + 2 more...
154 EBI-945833,EBI-2849569 ZFYVE21  
  .N/A .metal ion binding .cytoplasmic membrane-bounded vesicle
.focal adhesion
.endosome
155 EBI-945833,EBI-739863 KRTAP4-12  
  .N/A .N/A .keratin filament
156 EBI-945833,EBI-5457544 UTP23  
  .maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) .small ribosomal subunit rRNA binding
.poly(A) RNA binding
.small-subunit processome
.nucleolus
157 EBI-945833,EBI-739773 CRACR2A  
  .positive regulation of calcium ion transport
.activation of store-operated calcium channel activity
.immune system process
.store-operated calcium entry
.calcium ion binding .membrane
.Golgi apparatus
.cytoplasm
  + 2 more...
158 EBI-945833,EBI-741350 THAP7  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.C2H2 zinc finger domain binding
.protein N-terminus binding
.metal ion binding
.DNA binding
.nuclear speck
.chromosome
159 EBI-945833,EBI-741574 MXD3  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .nucleus
160 EBI-945833,EBI-748391 SCNM1  
  .RNA splicing
.mRNA processing
.metal ion binding
.enzyme binding
.nuclear speck
.nucleolus
.nucleus
161 EBI-945833,EBI-10185730 KRTAP9-4  
  .N/A .N/A .keratin filament
162 EBI-945833,EBI-1044640 KRTAP9-2  
  .N/A .N/A .keratin filament
163 EBI-945833,EBI-10302392 KRTAP4-11  
  .N/A .N/A .keratin filament
164 EBI-945833,EBI-10302547 KRTAP4-7  
  .hair cycle
.aging
.N/A .keratin filament
165 EBI-945833,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
166 EBI-945833,EBI-9996449 KRTAP3-1  
  .N/A .structural molecule activity .keratin filament
167 EBI-945833,EBI-1993677 ASPSCR1  
  .membrane organization
.regulation of glucose import
.glucose homeostasis
.intracellular protein transport
.N/A .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.endoplasmic reticulum-Golgi intermediate compartment membrane
  + 7 more...
168 EBI-945833,EBI-10303490 SEMA4C  
  .semaphorin-plexin signaling pathway
.muscle cell differentiation
.positive regulation of stress-activated MAPK cascade
  + 3 more...
.receptor activity .postsynaptic membrane
.synaptic vesicle membrane
.cell junction
  + 3 more...
169 EBI-945833,EBI-743787 YIPF3  
  .cell differentiation .N/A .intracellular membrane-bounded organelle
.transport vesicle
.integral component of membrane
  + 3 more...
170 EBI-945833,EBI-10303636 TINAGL1  
  .endosomal transport
.cell adhesion
.immune response
.polysaccharide binding
.cysteine-type peptidase activity
.extracellular matrix structural constituent
.scavenger receptor activity
.extracellular exosome
.cytoplasm
.extracellular space
.extracellular region
171 EBI-945833,EBI-748452 PCED1A  
  .N/A .N/A .N/A
172 EBI-945833,EBI-3918847 HSD3B7  
  .small molecule metabolic process
.bile acid metabolic process
.bile acid biosynthetic process
.cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity
.3-beta-hydroxy-delta5-steroid dehydrogenase activity
.integral component of membrane
.endoplasmic reticulum membrane
173 EBI-945833,EBI-947551 CHRD  
  .positive regulation of cell adhesion
.negative regulation of osteoblast differentiation
.floor plate development
  + 9 more...
.cytokine binding
.heparin binding
.extracellular space
174 EBI-945833,EBI-724478 PTPN23  
  .positive regulation of early endosome to late endosome transport
.positive regulation of adherens junction organization
.positive regulation of homophilic cell adhesion
  + 5 more...
.protein kinase binding
.protein tyrosine phosphatase activity
.extracellular exosome
.ciliary basal body
.cytoplasmic membrane-bounded vesicle
  + 5 more...
175 EBI-945833,EBI-2801103 SMOC1  
  .limb development
.regulation of osteoblast differentiation
.extracellular matrix organization
  + 4 more...
.extracellular matrix binding
.calcium ion binding
.basement membrane
176 EBI-945833,EBI-3923092 CST9L  
  .N/A .cysteine-type endopeptidase inhibitor activity .extracellular region
177 EBI-945833,EBI-741626 FAM124B  
  .N/A .N/A .N/A
178 EBI-945833,EBI-10307654 TMEM231  
  .cilium assembly
.smoothened signaling pathway
.N/A .ciliary membrane
.TCTN-B9D complex
.ciliary transition zone
.integral component of membrane
179 EBI-945833,EBI-10311198 SLC6A20  
  .transmembrane transport
.proline transport
.glycine transport
  + 3 more...
.amino acid transmembrane transporter activity
.neurotransmitter:sodium symporter activity
.apical plasma membrane
.integral component of plasma membrane
.plasma membrane
180 EBI-945833,EBI-1053902 MRPL40  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 3 more...
.poly(A) RNA binding .mitochondrial ribosome
.mitochondrial inner membrane
.mitochondrion
  + 2 more...
181 EBI-945833,EBI-9679045 DMRT3  
  .male sex differentiation
.regulation of odontogenesis of dentin-containing tooth
.ventral spinal cord interneuron specification
  + 4 more...
.protein heterodimerization activity
.metal ion binding
.protein homodimerization activity
  + 2 more...
.nucleus
182 EBI-945833,EBI-2826725 PVRL3  
  .retina morphogenesis in camera-type eye
.cell-cell junction organization
.adherens junction organization
  + 5 more...
.cell adhesion molecule binding
.protein homodimerization activity
.postsynaptic membrane
.apical junction complex
.integral component of membrane
  + 2 more...
183 EBI-945833,EBI-748927 NPDC1  
  .N/A .N/A .integral component of membrane
184 EBI-945833,EBI-769257 PLSCR4  
  .cellular response to lipopolysaccharide
.phospholipid scrambling
.CD4 receptor binding
.enzyme binding
.phospholipid scramblase activity
.calcium ion binding
.extracellular exosome
.integral component of membrane
.plasma membrane
185 EBI-945833,EBI-10313866 C19orf66  
  .N/A .N/A .N/A
186 EBI-945833,EBI-399076 MRGBP  
  .regulation of growth
.chromatin modification
.regulation of transcription, DNA-templated
  + 2 more...
.N/A .H4/H2A histone acetyltransferase complex
.nucleoplasm
.nucleus
187 EBI-945833,EBI-743375 CHCHD3  
  .mitochondrial fusion
.inner mitochondrial membrane organization
.negative regulation of transcription from RNA polymerase II promoter
.protein complex scaffold
.phosphatase binding
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.extracellular exosome
.mitochondrial inner membrane
.mitochondrion
  + 2 more...
188 EBI-945833,EBI-8799578 GFOD1  
  .N/A .oxidoreductase activity .extracellular region
189 EBI-945833,EBI-356763 HSPBP1  
  .negative regulation of catalytic activity
.positive regulation of proteasomal ubiquitin-dependent protein catabolic process
.positive regulation of protein ubiquitination
.protein folding
.enzyme inhibitor activity .N/A
190 EBI-945833,EBI-745520 ZNF581  
  .transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleus
191 EBI-945833,EBI-10319095 XCL2  
  .cell chemotaxis
.blood circulation
.signal transduction
.immune response
.chemokine activity .extracellular space
.extracellular region
192 EBI-945833,EBI-357355 UXT  
  .centrosome organization
.mitochondrion transport along microtubule
.microtubule cytoskeleton organization
.negative regulation of transcription from RNA polymerase II promoter
.beta-tubulin binding
.microtubule binding
.chromatin binding
.RNA polymerase II transcription corepressor activity
.cytoskeleton
.centrosome
.cytoplasm
.nucleus
193 EBI-945833,EBI-8636823 CTSZ  
  .epithelial tube branching involved in lung morphogenesis
.proteolysis involved in cellular protein catabolic process
.cellular protein metabolic process
  + 2 more...
.cysteine-type peptidase activity
.cysteine-type endopeptidase activity
.extracellular exosome
.intracellular membrane-bounded organelle
.plasma membrane
  + 3 more...
194 EBI-945833,EBI-750394 SLC25A10  
  .sulfide oxidation, using sulfide:quinone oxidoreductase
.transmembrane transport
.small molecule metabolic process
  + 9 more...
.dicarboxylic acid transmembrane transporter activity .integral component of membrane
.mitochondrial inner membrane
.nucleus
195 EBI-945833,EBI-713677 CRCT1  
  .N/A .N/A .N/A
196 EBI-945833,EBI-1759386 SLC23A1  
  .transepithelial L-ascorbic acid transport
.dehydroascorbic acid transport
.small molecule metabolic process
  + 12 more...
.sodium-dependent L-ascorbate transmembrane transporter activity
.dehydroascorbic acid transporter activity
.L-ascorbic acid transporter activity
  + 3 more...
.extracellular exosome
.intracellular organelle
.apical plasma membrane
  + 6 more...
197 EBI-945833,EBI-741528 CHIC2  
  .Golgi to plasma membrane transport .N/A .plasma membrane
.Golgi-associated vesicle
198 EBI-945833,EBI-717201 SPG7  
  .anterograde axon cargo transport
.nervous system development
.mitochondrion organization
.proteolysis
.unfolded protein binding
.zinc ion binding
.peptidase activity
  + 2 more...
.mitochondrial membrane
.integral component of membrane
.mitochondrion
199 EBI-945833,EBI-4291090 GNE  
  .carbohydrate phosphorylation
.cellular protein metabolic process
.post-translational protein modification
  + 6 more...
.metal ion binding
.N-acylmannosamine kinase activity
.UDP-N-acetylglucosamine 2-epimerase activity
  + 2 more...
.cytosol
.cytoplasm
200 EBI-945833,EBI-10326419 R3HDM2  
  .N/A .poly(A) RNA binding .nucleus
201 EBI-945833,EBI-718719 CARHSP1  
  .regulation of mRNA stability
.intracellular signal transduction
.regulation of transcription, DNA-templated
.phosphatase binding
.mRNA 3'-UTR binding
.DNA binding
.extracellular exosome
.P granule
.cytosol
.cytoplasmic mRNA processing body
202 EBI-945833,EBI-10327976 NEU2  
  .small molecule metabolic process
.cellular protein metabolic process
.post-translational protein modification
  + 6 more...
.exo-alpha-(2->8)-sialidase activity
.exo-alpha-(2->6)-sialidase activity
.exo-alpha-(2->3)-sialidase activity
.cytosol
.cytoplasm
203 EBI-945833,EBI-1045409 GTF3C5  
  .tRNA transcription from RNA polymerase III promoter
.5S class rRNA transcription from RNA polymerase III type 1 promoter
.skeletal muscle cell differentiation
  + 3 more...
.DNA binding .nucleoplasm
.transcription factor TFIIIC complex
204 EBI-945833,EBI-1048886 NUBP2  
  .small molecule metabolic process
.iron-sulfur cluster assembly
.4 iron, 4 sulfur cluster binding
.metal ion binding
.ATP binding
.nucleotide binding
.spindle pole centrosome
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
blood32
bone55
brain12
cervix103
connective tissue26
ear124
embryonic tissue9
eye9
heart78
intestine38
kidney4
larynx42
liver4
lung29
lymph node22
mammary gland112
mouth15
muscle28
ovary29
pancreas51
pharynx49
placenta60
prostate58
salivary gland148
skin23
stomach52
testis64
trachea19
umbilical cord72
uterus25
vascular19
Health State
TissuesTPM*
normal6
adrenal tumor79
breast (mammary gland) tumor53
cervical tumor86
chondrosarcoma60
colorectal tumor17
gastrointestinal tumor42
germ cell tumor11
glioma27
head and neck tumor7
kidney tumor14
leukemia42
lymphoma13
non-neoplasia10
ovarian tumor13
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
prostate cancer9
skin tumor7
soft tissue/muscle tissue tumor23
uterine tumor22
Developmental Stage
TissuesTPM*
adult6
embryoid body14
blastocyst16
neonate32
fetus10
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue14.7
adrenal gland6.1
appendix10.5
bone marrow11.3
cerebral cortex7.7
colon9.4
duodenum5
esophagus19
gallbladder14.4
heart muscle9.7
kidney9.2
liver9.5
lung12.9
lymph node13.3
ovary14.6
pancreas6.6
placenta11.2
prostate17.8
salivary gland8.2
skin22.5
small intestine6.6
spleen16.6
stomach7.3
testis33.4
thyroid gland16
urinary bladder10.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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