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> Protein (NX_Q7Z434)
Protein (NX_Q7Z434)
Protein
Gene SymbolMAVS to neXtProt (NX_Q7Z434)
DescriptionMitochondrial antiviral-signaling protein
Chromosome20
Location20p13 (3827487 ~ 3849280) to Ensembl
Sequene Features : Isoforms 6, Variants 90, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of peroxisome organization
.positive regulation of IP-10 production
.positive regulation of chemokine (C-C motif) ligand 5 production
  + 22 more...
.CARD domain binding
.protein kinase binding
.signal transducer activity
.mitochondrial membrane
.integral component of membrane
.peroxisomal membrane
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 90 11
2014-09-19protein level
6 59 11
2014-05-27protein level
6 56 11
2014-02-25protein level
6 56 11
2013-12-09protein level
6 38 11
2013-11-01protein level
6 36 11
2013-09-12protein level
6 36 11
2013-08-17protein level
4 33 11
2013-07-15protein level
4 24 14
2013-06-11protein level
4 24 14
2013-02-12protein level
3 20 15
2012-12-20protein level
3 18 15
2012-10-30protein level
3 23 15
2012-10-07protein level
3 23 15
2012-08-24protein level
3 23 15
2012-07-28protein level
3 27 15
2012-06-08protein level
3 18 15
2012-05-07protein level
3 18 15
2012-04-10protein level
3 18 15
2012-01-13protein level
3 18 15
2011-12-20protein level
3 37 15
2011-11-11protein level
3 37 14
2011-08-23protein level
3 37 14
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q7Z434-1
2 18 0 56492.9294
NX_Q7Z434-2
1 5 0 15985.1441
NX_Q7Z434-3
4 2 0 17031.4141
NX_Q7Z434-4
1 13 0 40443.1159
NX_Q7Z434-5
3 4 0 14376.0614
NX_Q7Z434-6
4 1 0 15002.5951
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-995373,EBI-353779 DDX3X  
  .negative regulation of intrinsic apoptotic signaling pathway
.positive regulation of G1/S transition of mitotic cell cycle
.intrinsic apoptotic signaling pathway
  + 28 more...
.mRNA 5'-UTR binding
.poly(A) RNA binding
.CTPase activity
  + 14 more...
.extracellular exosome
.nuclear speck
.cytoplasmic stress granule
  + 4 more...
2 EBI-995373,EBI-358522 RIPK2  
  .cellular response to muramyl dipeptide
.cellular response to peptidoglycan
.cellular response to lipoteichoic acid
  + 57 more...
.CARD domain binding
.protein homodimerization activity
.LIM domain binding
  + 4 more...
.protein complex
.vesicle
.cytoskeleton
  + 2 more...
3 EBI-995373,EBI-995350 DDX58  
  .positive regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 17 more...
.identical protein binding
.zinc ion binding
.ATP binding
  + 4 more...
.ruffle membrane
.actin cytoskeleton
.tight junction
  + 2 more...
4 EBI-995373,EBI-375543 ABL1  
  .regulation of response to DNA damage stimulus
.negative regulation of cellular senescence
.negative regulation of endothelial cell apoptotic process
  + 73 more...
.proline-rich region binding
.mitogen-activated protein kinase binding
.manganese ion binding
  + 12 more...
.perinuclear region of cytoplasm
.nuclear membrane
.cell leading edge
  + 8 more...
5 EBI-995373,EBI-1057697 STAT1  
  .negative regulation of metanephric nephron tubule epithelial cell differentiation
.metanephric mesenchymal cell differentiation
.metanephric mesenchymal cell proliferation involved in metanephros development
  + 37 more...
.protein homodimerization activity
.identical protein binding
.enzyme binding
  + 7 more...
.dendrite
.axon
.cytosol
  + 5 more...
6 EBI-995373,EBI-347552 BAG6  
  .tail-anchored membrane protein insertion into ER membrane
.intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
.protein stabilization
  + 17 more...
.proteasome binding
.ribosome binding
.ubiquitin protein ligase binding
.polyubiquitin binding
.BAT3 complex
.intracellular membrane-bounded organelle
.cytosol
  + 3 more...
7 EBI-995373,EBI-347528 C1QBP  
  .positive regulation of dendritic cell chemotaxis
.positive regulation of trophoblast cell migration
.positive regulation of substrate adhesion-dependent cell spreading
  + 25 more...
.mitochondrial ribosome binding
.adrenergic receptor binding
.kininogen binding
  + 5 more...
.membrane
.cell surface
.plasma membrane
  + 7 more...
8 EBI-995373,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
9 EBI-995373,EBI-3931258 IRF5  
  .type I interferon signaling pathway
.interferon-gamma-mediated signaling pathway
.defense response to virus
  + 9 more...
.sequence-specific DNA binding transcription factor activity
.regulatory region DNA binding
.cytosol
.cytoplasm
.nucleus
10 EBI-995373,EBI-1048119 UBE4A  
  .ubiquitin-dependent protein catabolic process
.protein polyubiquitination
.ubiquitin-ubiquitin ligase activity
.ligase activity
.cytoplasm
.ubiquitin ligase complex
11 EBI-995373,EBI-307369 IKBKE  
  .innate immune response
.positive regulation of I-kappaB kinase/NF-kappaB signaling
.NIK/NF-kappaB signaling
  + 9 more...
.IkappaB kinase activity
.ATP binding
.NF-kappaB-inducing kinase activity
.mitochondrial membrane
.PML body
.endosome membrane
  + 4 more...
12 EBI-995373,EBI-2800345 TMEM173  
  .cellular response to exogenous dsRNA
.defense response to virus
.positive regulation of transcription from RNA polymerase II promoter
  + 11 more...
.cyclic-GMP-AMP binding
.protein homodimerization activity
.identical protein binding
  + 3 more...
.perinuclear region of cytoplasm
.cytoplasmic vesicle membrane
.integral component of membrane
  + 5 more...
13 EBI-995373,EBI-1048197 MFN1  
  .mitochondrial fusion .GTP binding
.GTPase activity
.integral component of membrane
.mitochondrial outer membrane
.mitochondrion
14 EBI-995373,EBI-6253230 NLRP3  
  .cellular response to lipopolysaccharide
.defense response to virus
.protein oligomerization
  + 20 more...
.peptidoglycan binding
.ATP binding
.NLRP3 inflammasome complex
.cytosol
.cytoplasm
15 EBI-995373,EBI-6115771 IFIH1  
  .innate immune response
.regulation of apoptotic process
.cytoplasmic pattern recognition receptor signaling pathway in response to virus
  + 8 more...
.ribonucleoprotein complex binding
.zinc ion binding
.ATP binding
  + 4 more...
.cytosol
.nucleus
16 EBI-995373,EBI-751501 KCNIP3  
  .regulation of potassium ion transmembrane transport
.protein localization to plasma membrane
.behavioral response to pain
  + 8 more...
.sequence-specific DNA binding
.potassium channel regulator activity
.calcium ion binding
  + 4 more...
.axon terminus
.protein-DNA complex
.dendrite
  + 5 more...
17 EBI-995373,EBI-6115729 OAS3  
  .regulation of ribonuclease activity
.type I interferon signaling pathway
.interferon-gamma-mediated signaling pathway
  + 5 more...
.metal ion binding
.ATP binding
.double-stranded RNA binding
.2'-5'-oligoadenylate synthetase activity
.intracellular membrane-bounded organelle
.plasma membrane
.cytosol
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites75
bladder33
blood114
bone111
bone marrow20
brain63
cervix144
connective tissue26
embryonic tissue70
eye43
heart22
intestine155
kidney75
larynx42
liver48
lung56
lymph67
lymph node11
mammary gland178
mouth166
muscle103
nerve257
ovary137
pancreas93
pituitary gland60
placenta91
prostate94
salivary gland49
skin99
spleen112
stomach83
testis25
thymus225
thyroid150
trachea154
umbilical cord72
uterus73
vascular116
Health State
TissuesTPM*
normal59
bladder carcinoma56
breast (mammary gland) tumor247
cervical tumor202
chondrosarcoma60
colorectal tumor231
gastrointestinal tumor92
germ cell tumor60
glioma167
head and neck tumor134
kidney tumor159
leukemia84
liver tumor52
lung tumor87
lymphoma110
non-neoplasia41
ovarian tumor196
pancreatic tumor133
primitive neuroectodermal tumor of the CNS23
prostate cancer105
skin tumor135
soft tissue/muscle tissue tumor79
uterine tumor33
Developmental Stage
TissuesTPM*
adult98
embryoid body128
blastocyst48
neonate96
fetus50
infant42
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.2
adrenal gland8.1
appendix13.3
bone marrow8.4
cerebral cortex8.4
colon16.3
duodenum14.2
esophagus14.3
gallbladder9.3
heart muscle12.6
kidney10.8
liver3.1
lung11.5
lymph node10.4
ovary14.3
pancreas8.8
placenta11
prostate10.6
salivary gland10.5
skin12.5
small intestine13.5
spleen12.8
stomach11
testis6.7
thyroid gland14.9
urinary bladder11.9
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumMedium
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleMedium
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1Low
soft tissue 2Medium
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609676, gene) Mitochondrial antiviral signaling protein; MAVSOMIM


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