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> Protein (NX_Q7Z494)
Protein (NX_Q7Z494)
Protein
Gene SymbolNPHP3 to neXtProt (NX_Q7Z494)
DescriptionNephrocystin-3
Chromosome3
Location3q22.1 (132276986 ~ 132441303) to Ensembl
Sequene Features : Isoforms 7, Variants 141, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of planar cell polarity pathway involved in neural tube closure
.regulation of Wnt signaling pathway, planar cell polarity pathway
.negative regulation of canonical Wnt signaling pathway
  + 18 more...
.N/A .primary cilium
.cilium
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
7 141 1
2014-09-19protein level
7 111 1
2014-05-27protein level
7 110 1
2014-02-25protein level
7 109 1
2013-12-09protein level
7 86 1
2013-11-01protein level
7 83 1
2013-09-12protein level
7 83 1
2013-08-17protein level
7 83 1
2013-07-15protein level
7 55 1
2013-06-11protein level
7 55 1
2013-02-12protein level
7 36 6
2012-12-20protein level
7 35 6
2012-10-30protein level
7 41 6
2012-10-07protein level
7 41 1
2012-08-24protein level
7 33 1
2012-07-28protein level
7 33 1
2012-06-08protein level
7 10 1
2012-05-07protein level
7 10 1
2012-04-10protein level
7 10 1
2012-01-13protein level
7 10 0
2011-12-20protein level
7 10 0
2011-11-11protein level
7 10 0
2011-08-23protein level
7 10 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q7Z494-1
1 58 0 150768.9431
NX_Q7Z494-2
1 32 0 72967.3509
NX_Q7Z494-3
1 21 0 71056.9289
NX_Q7Z494-4
2 5 0 19126.5988
NX_Q7Z494-5
1 8 0 26325.4223
NX_Q7Z494-6
0 26 0 79082.152
NX_Q7Z494-7
2 5 0 15788.1174
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2804263,EBI-3937015 CEP164  
  .cell division
.cilium assembly
.mitotic nuclear division
  + 4 more...
.N/A .ciliary transition fiber
.cytosol
.centriole
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
blood24
brain22
ear124
embryonic tissue32
eye38
heart11
intestine21
kidney9
liver9
lung8
lymph node22
mammary gland33
mouth15
nerve64
ovary9
pancreas18
placenta14
prostate26
salivary gland49
skin18
spleen93
testis18
thymus50
thyroid21
trachea57
uterus34
vascular77
Health State
TissuesTPM*
normal26
breast (mammary gland) tumor21
colorectal tumor44
germ cell tumor18
head and neck tumor14
kidney tumor14
leukemia10
liver tumor10
lymphoma13
ovarian tumor13
prostate cancer9
skin tumor15
soft tissue/muscle tissue tumor23
uterine tumor33
Developmental Stage
TissuesTPM*
adult21
embryoid body71
neonate32
fetus30
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.9
adrenal gland16.3
appendix13.2
bone marrow5.5
cerebral cortex8.2
colon8.9
duodenum8.6
esophagus9.1
gallbladder15.6
heart muscle8.1
kidney9.3
liver5.3
lung17.2
lymph node13.2
ovary35.1
pancreas6.1
placenta13.7
prostate18.1
salivary gland8.9
skin22
small intestine10.3
spleen15.5
stomach8.7
testis10
thyroid gland17.2
urinary bladder10.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#208540, phenotype) Renal-hepatic-pancreatic dysplasia; RHPDOMIM
2(#267010, phenotype) Meckel syndrome, type 7; MKS7OMIM
3(#604387, phenotype) Nephronophthisis 3; NPHP3OMIM
4(*608002, gene) Nephrocystin 3; NPHP3OMIM


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