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> Protein (NX_Q7Z4I7)
Protein (NX_Q7Z4I7)
Protein
Gene SymbolLIMS2 to neXtProt (NX_Q7Z4I7)
DescriptionLIM and senescent cell antigen-like-containing domain protein 2
Chromosome2
Location2q14.3 (128395956 ~ 128439360) to Ensembl
Sequene Features : Isoforms 5, Variants 45, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of integrin-mediated signaling pathway
.negative regulation of hepatocyte proliferation
.negative regulation of neural precursor cell proliferation
  + 4 more...
.zinc ion binding .focal adhesion
.plasma membrane
.cytosol
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 45 3
2014-09-19protein level
5 36 3
2014-05-27protein level
5 36 3
2014-02-25protein level
5 35 3
2013-12-09protein level
5 23 3
2013-11-01protein level
5 22 3
2013-09-12protein level
5 22 3
2013-08-17protein level
5 22 3
2013-07-15protein level
5 16 3
2013-06-11protein level
5 16 3
2013-02-12protein level
3 7 6
2012-12-20protein level
3 6 6
2012-10-30protein level
3 6 6
2012-10-07protein level
3 6 2
2012-08-24protein level
3 4 2
2012-07-28protein level
3 4 2
2012-06-08protein level
3 5 2
2012-05-07protein level
3 5 2
2012-04-10protein level
3 5 2
2012-01-13protein level
3 3 2
2011-12-20protein level
3 3 2
2011-11-11protein level
3 3 2
2011-08-23protein level
3 3 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q7Z4I7-1
1 8 6 38889.4566
NX_Q7Z4I7-2
2 8 6 41483.9014
NX_Q7Z4I7-3
1 8 6 38399.2733
NX_Q7Z4I7-4
0 3 5 21600.4811
NX_Q7Z4I7-5
2 8 6 41197.6797
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10257651,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
2 EBI-10257651,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
3 EBI-10257651,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
4 EBI-10257651,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
5 EBI-10257651,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
6 EBI-10257651,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
7 EBI-10257651,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
8 EBI-10257651,EBI-947779 RCHY1  
  .error-free translesion synthesis
.protein autoubiquitination
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 5 more...
.protein homodimerization activity
.ligase activity
.zinc ion binding
  + 2 more...
.nuclear speck
.cytoplasm
.nucleoplasm
  + 2 more...
9 EBI-10257651,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
blood98
bone83
brain40
cervix41
connective tissue33
embryonic tissue14
esophagus99
eye23
heart134
intestine125
kidney9
liver38
lung35
lymph node22
mammary gland72
muscle9
nerve193
ovary9
pancreas32
placenta31
prostate68
skin23
spleen149
stomach94
testis20
thymus75
trachea19
umbilical cord72
uterus81
vascular38
Health State
TissuesTPM*
normal54
cervical tumor28
chondrosarcoma36
colorectal tumor44
gastrointestinal tumor42
germ cell tumor22
glioma139
leukemia127
liver tumor10
lung tumor9
non-neoplasia41
pancreatic tumor28
primitive neuroectodermal tumor of the CNS7
prostate cancer38
skin tumor7
soft tissue/muscle tissue tumor15
uterine tumor33
Developmental Stage
TissuesTPM*
adult45
embryoid body14
neonate32
fetus55
infant42
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue45.5
adrenal gland9.8
appendix18.9
cerebral cortex13.1
colon23
duodenum13.2
esophagus36.7
gallbladder30
heart muscle72.8
kidney16.1
liver13.3
lung53.4
lymph node17
ovary6
pancreas3.7
placenta21.5
prostate50.4
salivary gland14.9
skin11.3
small intestine15.9
spleen60.5
stomach8
testis7.2
thyroid gland12.7
urinary bladder50.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607908, gene) Lim and senescent cell antigen-like domains 2; LIMS2OMIM


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