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> Protein (NX_Q7Z4N8)
Protein (NX_Q7Z4N8)
Protein
Gene SymbolP4HA3 to neXtProt (NX_Q7Z4N8)
DescriptionProlyl 4-hydroxylase subunit alpha-3
Chromosome11
Location11q13.4 (73946846 ~ 74022702) to Ensembl
Sequene Features : Isoforms 3, Variants 74, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .L-ascorbic acid binding
.oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
.iron ion binding
.procollagen-proline 4-dioxygenase activity
.endoplasmic reticulum lumen
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 74 2
2014-09-19protein level
3 48 2
2014-05-27protein level
3 48 2
2014-02-25protein level
2 47 2
2013-12-09protein level
2 34 2
2013-11-01protein level
2 30 2
2013-09-12protein level
2 30 2
2013-08-17protein level
2 30 2
2013-07-15protein level
2 22 2
2013-06-11protein level
2 22 2
2013-02-12protein level
2 12 3
2012-12-20protein level
2 11 3
2012-10-30protein level
2 17 3
2012-10-07protein level
2 17 2
2012-08-24protein level
2 15 2
2012-07-28protein level
2 15 2
2012-06-08protein level
2 16 2
2012-05-07protein level
2 16 2
2012-04-10protein level
2 16 2
2012-01-13protein level
2 3 2
2011-12-20protein level
2 3 2
2011-11-11protein level
2 3 2
2011-08-23protein level
2 3 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q7Z4N8-1
4 19 0 61088.023
NX_Q7Z4N8-2
0 11 0 28682.7348
NX_Q7Z4N8-3
6 19 0 67548.2252
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10181968,EBI-740220 HGS  
  .positive regulation of exosomal secretion
.protein localization to membrane
.membrane organization
  + 13 more...
.metal ion binding
.protein domain specific binding
.extracellular exosome
.intracellular membrane-bounded organelle
.multivesicular body membrane
  + 6 more...
2 EBI-10181968,EBI-714790 WDR62  
  .neurogenesis
.cerebral cortex development
.N/A .cytoplasm
.nucleoplasm
.nucleus
.spindle pole
3 EBI-10181968,EBI-747793 ZC3H12A  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to lipopolysaccharide
.positive regulation of fat cell differentiation
  + 12 more...
.metal ion binding
.endonuclease activity
.plasma membrane
.cytoplasm
.nucleoplasm
4 EBI-10181968,EBI-10178410 NUTM1  
  .N/A .N/A .cytoplasm
.nucleus
5 EBI-10181968,EBI-465804 DTNBP1  
  .membrane organization
.regulation of dopamine receptor signaling pathway
.platelet dense granule organization
  + 11 more...
.N/A .postsynaptic membrane
.dendritic spine
.neuron projection
  + 14 more...
6 EBI-10181968,EBI-5651487 MAGEC2  
  .positive regulation of ubiquitin-protein transferase activity
.cellular protein catabolic process
.ubiquitin protein ligase binding .cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone marrow20
connective tissue26
ear62
eye9
intestine8
kidney4
larynx42
lung8
mammary gland13
mouth45
pancreas4
placenta14
prostate21
skin4
stomach10
testis18
uterus17
vascular38
Health State
TissuesTPM*
normal8
breast (mammary gland) tumor10
chondrosarcoma60
gastrointestinal tumor8
germ cell tumor3
head and neck tumor29
pancreatic tumor9
Developmental Stage
TissuesTPM*
adult10
neonate32
fetus5
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.5
appendix5
gallbladder6.9
lymph node1.1
placenta4.7
prostate4.3
testis2.1
thyroid gland2.1
urinary bladder9.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608987, gene) Procollagen-proline, 2-oxoglutarate-4-dioxygenase, alpha subunit,OMIM


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