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> Protein (NX_Q7Z589)
Protein (NX_Q7Z589)
Protein
Gene SymbolEMSY to neXtProt (NX_Q7Z589)
DescriptionProtein EMSY
Chromosome11
Location11q13.5 (76155967 ~ 76264069) to Ensembl
Sequene Features : Isoforms 7, Variants 28, PTMs 21 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.chromatin modification
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA repair
.N/A .nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
7 28 21
2014-09-19protein level
7 112 21
2014-05-27protein level
7 110 21
2014-02-25protein level
3 109 21
2013-12-09protein level
3 91 21
2013-11-01protein level
3 88 21
2013-09-12protein level
3 88 15
2013-08-17protein level
3 88 15
2013-07-15protein level
3 62 11
2013-06-11protein level
3 62 11
2013-02-12protein level
3 29 18
2012-12-20protein level
3 26 18
2012-10-30protein level
3 33 18
2012-10-07protein level
3 33 10
2012-08-24protein level
3 28 10
2012-07-28protein level
3 28 10
2012-06-08protein level
3 31 10
2012-05-07protein level
3 16 10
2012-04-10protein level
3 16 10
2012-01-13protein level
3 11 10
2011-12-20protein level
3 11 10
2011-11-11protein level
3 11 10
2011-08-23protein level
3 11 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q7Z589-1
0 62 0 141380.0953
NX_Q7Z589-2
1 53 0 123838.1379
NX_Q7Z589-3
0 4 0 9346.112
NX_Q7Z589-4
1 60 0 141546.224
NX_Q7Z589-5
0 62 0 141479.1634
NX_Q7Z589-6
1 56 0 131094.9536
NX_Q7Z589-7
0 62 0 143103.9872
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-6598631,EBI-745608 ZNF646  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
2 EBI-6598631,EBI-10173632 DDIT3  
  .negative regulation of determination of dorsal identity
.positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
  + 32 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.leucine zipper domain binding
  + 8 more...
.CHOP-ATF3 complex
.CHOP-ATF4 complex
.CHOP-C/EBP complex
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
bone13
bone marrow41
brain13
cervix82
connective tissue13
embryonic tissue18
eye47
heart44
intestine25
kidney42
liver19
lung14
lymph node66
mammary gland33
mouth30
muscle9
ovary39
pancreas32
parathyroid48
pharynx24
placenta81
prostate21
salivary gland49
skin14
spleen56
stomach31
testis18
thymus25
thyroid21
trachea77
uterus25
Health State
TissuesTPM*
normal31
bladder carcinoma56
breast (mammary gland) tumor10
cervical tumor28
chondrosarcoma12
colorectal tumor44
gastrointestinal tumor33
germ cell tumor11
glioma18
head and neck tumor22
kidney tumor29
leukemia10
liver tumor20
non-neoplasia41
ovarian tumor39
primitive neuroectodermal tumor of the CNS15
soft tissue/muscle tissue tumor15
uterine tumor33
Developmental Stage
TissuesTPM*
adult32
embryoid body42
blastocyst16
fetus37
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.8
adrenal gland8.1
appendix8.8
bone marrow8.2
cerebral cortex7.3
colon7.8
duodenum5.1
esophagus6
gallbladder7.1
heart muscle7.7
kidney6.7
liver3.5
lung8
lymph node9.1
ovary12.5
pancreas4.4
placenta12.6
prostate7.4
salivary gland6.1
skin6
small intestine5.7
spleen8.1
stomach6.2
testis10.7
thyroid gland9.4
urinary bladder10
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608574, gene) Emsy geneOMIM


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