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> Protein (NX_Q7Z6B7)
Protein (NX_Q7Z6B7)
Protein
Gene SymbolSRGAP1 to neXtProt (NX_Q7Z6B7)
DescriptionSLIT-ROBO Rho GTPase-activating protein 1
Chromosome12
Location12q14.2 (64238073 ~ 64541613) to Ensembl
Sequene Features : Isoforms 2, Variants 145, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of small GTPase mediated signal transduction
.negative regulation of cell migration
.cell migration
  + 3 more...
.Rac GTPase binding
.GTPase activator activity
.cytosol
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 145 8
2014-09-19protein level
2 115 8
2014-05-27protein level
2 115 8
2014-02-25protein level
2 115 8
2013-12-09protein level
2 95 8
2013-11-01protein level
2 92 8
2013-09-12protein level
2 92 8
2013-08-17protein level
2 92 8
2013-07-15protein level
2 55 8
2013-06-11protein level
2 55 8
2013-02-12protein level
2 19 22
2012-12-20protein level
2 20 22
2012-10-30protein level
2 27 22
2012-10-07protein level
2 27 11
2012-08-24protein level
2 25 11
2012-07-28protein level
2 25 11
2012-06-08protein level
2 26 11
2012-05-07protein level
2 17 11
2012-04-10protein level
2 17 11
2012-01-13protein level
2 16 11
2011-12-20protein level
2 16 11
2011-11-11protein level
2 16 10
2011-08-23protein level
2 16 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q7Z6B7-1
3 39 8 124185.971
NX_Q7Z6B7-2
2 39 8 121517.4794
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2481729,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
bladder33
bone55
bone marrow20
brain28
connective tissue33
embryonic tissue4
eye43
heart11
intestine30
kidney80
liver38
lung32
lymph node11
mammary gland13
mouth60
muscle28
nerve64
ovary29
pancreas28
placenta3
prostate10
skin123
spleen18
stomach31
testis16
thyroid128
trachea19
uterus17
vascular19
Health State
TissuesTPM*
normal28
bladder carcinoma56
breast (mammary gland) tumor21
chondrosarcoma72
colorectal tumor53
gastrointestinal tumor42
germ cell tumor30
glioma55
head and neck tumor44
kidney tumor188
liver tumor41
non-neoplasia20
ovarian tumor39
pancreatic tumor9
prostate cancer9
skin tumor199
soft tissue/muscle tissue tumor31
uterine tumor22
Developmental Stage
TissuesTPM*
adult31
embryoid body14
blastocyst32
fetus75
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.8
adrenal gland2.3
appendix2.3
cerebral cortex3.3
colon3.4
duodenum2.4
esophagus2.3
gallbladder3.9
heart muscle1.3
kidney2.6
lung4.5
ovary3.1
pancreas2.1
placenta1.7
prostate1.2
salivary gland3.4
small intestine1.7
spleen2.5
stomach2.1
testis5.4
thyroid gland4.7
urinary bladder1.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606523, gene) Slit-robo rho gtpase-activating protein 1; SRGAP1OMIM


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