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> Protein (NX_Q7Z6E9)
Protein (NX_Q7Z6E9)
Protein
Gene SymbolRBBP6 to neXtProt (NX_Q7Z6E9)
DescriptionE3 ubiquitin-protein ligase RBBP6
Chromosome16
Location16p12.1 (24549014 ~ 24584184) to Ensembl
Sequene Features : Isoforms 4, Variants 204, PTMs 31 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.somite development
.embryonic organ development
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 2 more...
.poly(A) RNA binding
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.microtubule organizing center
.cytoplasm
.nucleolus
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 204 31
2014-09-19protein level
4 143 31
2014-05-27protein level
4 142 34
2014-02-25protein level
4 142 33
2013-12-09protein level
4 112 33
2013-11-01protein level
4 107 31
2013-09-12protein level
4 107 31
2013-08-17protein level
4 107 31
2013-07-15protein level
4 60 31
2013-06-11protein level
4 60 31
2013-02-12protein level
4 27 85
2012-12-20protein level
4 25 85
2012-10-30protein level
4 35 85
2012-10-07protein level
4 35 36
2012-08-24protein level
4 35 36
2012-07-28protein level
4 34 36
2012-06-08protein level
4 37 36
2012-05-07protein level
4 29 36
2012-04-10protein level
4 29 36
2012-01-13protein level
4 17 36
2011-12-20protein level
4 17 36
2011-11-11protein level
4 17 32
2011-08-23protein level
4 17 30
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q7Z6E9-1
1 58 0 201441.1167
NX_Q7Z6E9-2
0 58 0 197166.8547
NX_Q7Z6E9-3
1 4 0 13226.8007
NX_Q7Z6E9-4
1 33 0 105971.1705
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2117026,EBI-398885 SRSF7  
  .negative regulation of mRNA splicing, via spliceosome
.mRNA 3'-end processing
.gene expression
  + 6 more...
.poly(A) RNA binding
.zinc ion binding
.nucleotide binding
.extracellular exosome
.cytoplasm
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites50
bladder66
blood49
bone125
bone marrow61
brain44
cervix82
connective tissue73
ear124
embryonic tissue136
esophagus49
eye71
heart55
intestine64
kidney128
larynx127
liver63
lung89
lymph node167
mammary gland66
mouth45
muscle65
ovary9
pancreas46
parathyroid194
pituitary gland121
placenta208
prostate153
skin28
spleen93
stomach94
testis91
thymus75
thyroid64
umbilical cord145
uterus90
vascular19
Health State
TissuesTPM*
normal91
bladder carcinoma113
breast (mammary gland) tumor64
cervical tumor115
chondrosarcoma108
colorectal tumor79
esophageal tumor57
gastrointestinal tumor84
germ cell tumor174
glioma158
head and neck tumor44
kidney tumor72
leukemia127
liver tumor62
lung tumor9
non-neoplasia82
ovarian tumor13
pancreatic tumor19
prostate cancer202
skin tumor15
soft tissue/muscle tissue tumor71
uterine tumor99
Developmental Stage
TissuesTPM*
adult113
embryoid body100
blastocyst195
neonate64
fetus111
infant42
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue24.5
adrenal gland29.2
appendix27
bone marrow96.2
cerebral cortex20
colon20.1
duodenum17.3
esophagus19.8
gallbladder26.2
heart muscle17.1
kidney16.8
liver13.2
lung22.4
lymph node28.5
ovary36.9
pancreas7
placenta39.7
prostate29.6
salivary gland14.3
skin25.5
small intestine20.8
spleen31.7
stomach21.6
testis39.3
thyroid gland23
urinary bladder22.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600938, gene) Retinoblastoma-binding protein 6; RBBP6OMIM


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