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> Protein (NX_Q7Z6J4)
Protein (NX_Q7Z6J4)
Protein
Gene SymbolFGD2 to neXtProt (NX_Q7Z6J4)
DescriptionFYVE, RhoGEF and PH domain-containing protein 2
Chromosome6
Location6p21.2 (36973422 ~ 36996846) to Ensembl
Sequene Features : Isoforms 4, Variants 104, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.apoptotic signaling pathway
.regulation of small GTPase mediated signal transduction
.neurotrophin TRK receptor signaling pathway
  + 8 more...
.metal ion binding
.small GTPase binding
.Rho guanyl-nucleotide exchange factor activity
.guanyl-nucleotide exchange factor activity
.ruffle membrane
.early endosome membrane
.lamellipodium
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 104 0
2014-09-19protein level
4 83 0
2014-05-27transcript level
4 83 0
2014-02-25transcript level
4 84 0
2013-12-09transcript level
4 59 0
2013-11-01transcript level
4 56 0
2013-09-12transcript level
4 56 0
2013-08-17protein level
4 56 0
2013-07-15protein level
4 41 0
2013-06-11protein level
4 41 0
2013-02-12protein level
4 25 0
2012-12-20protein level
4 25 0
2012-10-30protein level
4 33 0
2012-10-07protein level
4 33 0
2012-08-24transcript level
4 31 0
2012-07-28transcript level
4 31 0
2012-06-08transcript level
4 1 0
2012-05-07transcript level
4 1 0
2012-04-10transcript level
4 1 0
2012-01-13transcript level
4 1 0
2011-12-20transcript level
4 1 0
2011-11-11transcript level
4 1 0
2011-08-23transcript level
4 1 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q7Z6J4-1
20 10 0 74844.6299
NX_Q7Z6J4-2
2 5 0 20179.9492
NX_Q7Z6J4-4
1 4 0 16075.6965
NX_Q7Z6J4-5
4 2 0 13815.9786
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1057190,EBI-740929 KLHL12  
  .negative regulation of canonical Wnt signaling pathway
.COPII vesicle coating
.Wnt signaling pathway
  + 2 more...
.N/A .Cul3-RING ubiquitin ligase complex
.ER to Golgi transport vesicle
.cytosol
.Golgi membrane
2 EBI-1057190,EBI-9675724 TMEM239  
  .N/A .N/A .integral component of membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
blood32
brain9
eye4
intestine12
lung8
lymph22
lymph node11
placenta10
spleen187
thymus12
tonsil117
Health State
TissuesTPM*
normal9
leukemia74
lung tumor9
lymphoma13
non-neoplasia31
Developmental Stage
TissuesTPM*
adult6
neonate32
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.2
adrenal gland8
appendix50.2
bone marrow5.2
cerebral cortex4.3
colon8.4
duodenum11.3
esophagus4.9
gallbladder12.1
heart muscle2.9
kidney1.8
liver4
lung15.1
lymph node57.2
ovary2.8
pancreas2.2
placenta6.9
prostate2.9
salivary gland3.9
skin3.8
small intestine16
spleen103.2
stomach11.2
testis3.2
thyroid gland7.9
urinary bladder15.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605091, gene) Fyve, rhogef, and ph domain-containing protein 2; FGD2OMIM


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