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> Protein (NX_Q7Z6Z7)
Protein (NX_Q7Z6Z7)
Protein
Gene SymbolHUWE1 to neXtProt (NX_Q7Z6Z7)
DescriptionE3 ubiquitin-protein ligase HUWE1
ChromosomeX
LocationXp11.22 (53559057 ~ 53713673) to Ensembl
Sequene Features : Isoforms 3, Variants 442, PTMs 84 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of protein targeting to mitochondrion
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.cell differentiation
  + 4 more...
.poly(A) RNA binding
.ligase activity
.ubiquitin-protein transferase activity
.DNA binding
.extracellular exosome
.membrane
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 442 84
2014-09-19protein level
3 328 84
2014-05-27protein level
3 328 84
2014-02-25protein level
3 326 82
2013-12-09protein level
3 305 83
2013-11-01protein level
3 288 70
2013-09-12protein level
3 288 70
2013-08-17protein level
3 288 69
2013-07-15protein level
3 158 39
2013-06-11protein level
3 158 39
2013-02-12protein level
3 61 129
2012-12-20protein level
3 60 129
2012-10-30protein level
3 67 129
2012-10-07protein level
3 67 43
2012-08-24protein level
3 21 43
2012-07-28protein level
3 21 43
2012-06-08protein level
3 29 43
2012-05-07protein level
3 29 43
2012-04-10protein level
3 29 43
2012-01-13protein level
3 22 43
2011-12-20protein level
3 22 43
2011-11-11protein level
3 22 39
2011-08-23protein level
3 22 39
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q7Z6Z7-1
0 185 0 481587.2844
NX_Q7Z6Z7-2
1 184 0 479895.412
NX_Q7Z6Z7-3
1 183 0 480714.8407
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-625934,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-625934,EBI-352682 HSPB1  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
.platelet aggregation
  + 17 more...
.poly(A) RNA binding
.ubiquitin binding
.identical protein binding
  + 3 more...
.extracellular exosome
.Z disc
.focal adhesion
  + 8 more...
3 EBI-625934,EBI-723290 USP4  
  .regulation of proteasomal protein catabolic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
.protein localization to cell surface
  + 4 more...
.metal ion binding
.identical protein binding
.adenosine receptor binding
  + 2 more...
.plasma membrane
.lysosome
.cytoplasm
.nucleus
4 EBI-625934,EBI-625922 CDKN2A  
  .negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of protein targeting to mitochondrion
.negative regulation of proteolysis involved in cellular protein catabolic process
  + 33 more...
.MDM2/MDM4 family protein binding
.ubiquitin-protein transferase inhibitor activity
.transcription factor binding
  + 2 more...
.protein complex
.mitochondrion
.nucleolus
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland91
ascites25
bladder334
blood220
bone125
bone marrow41
brain153
cervix268
connective tissue67
ear372
embryonic tissue187
esophagus49
eye134
heart100
intestine452
kidney147
larynx1406
liver131
lung262
lymph293
lymph node278
mammary gland310
mouth302
muscle159
nerve64
ovary197
pancreas107
parathyroid97
pharynx196
pituitary gland847
placenta219
prostate348
skin137
spleen74
stomach10
testis128
thymus150
thyroid128
tonsil58
trachea115
umbilical cord871
uterus112
vascular58
Health State
TissuesTPM*
normal167
adrenal tumor158
bladder carcinoma511
breast (mammary gland) tumor257
cervical tumor376
chondrosarcoma217
colorectal tumor826
esophageal tumor57
gastrointestinal tumor50
germ cell tumor197
glioma102
head and neck tumor440
kidney tumor217
leukemia317
liver tumor124
lung tumor126
lymphoma221
non-neoplasia93
ovarian tumor196
pancreatic tumor142
primitive neuroectodermal tumor of the CNS47
prostate cancer558
retinoblastoma193
skin tumor143
soft tissue/muscle tissue tumor103
uterine tumor99
Developmental Stage
TissuesTPM*
adult315
embryoid body157
blastocyst260
neonate128
fetus183
infant85
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue25.5
adrenal gland32.5
appendix28.4
bone marrow26.5
cerebral cortex28.6
colon27
duodenum21.1
esophagus22.1
gallbladder24.7
heart muscle24.3
kidney31.7
liver18.3
lung25.4
lymph node32.2
ovary46.7
pancreas16.5
placenta27
prostate28
salivary gland25.1
skin61.5
small intestine20.4
spleen30.9
stomach26.3
testis39.1
thyroid gland31.7
urinary bladder26.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Low
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungLow
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateLow
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*300697, gene) Hect, uba, and wwe domains-containing protein 1; HUWE1OMIM
2(#300705, phenotype) Mental retardation, x-linked 17; MRX17OMIM
3(#300706, phenotype) Mental retardation, x-linked, syndromic, turner type; MRXSTOMIM


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