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> Protein (NX_Q7Z7G1)
Protein (NX_Q7Z7G1)
Protein
Gene SymbolCLNK to neXtProt (NX_Q7Z7G1)
DescriptionCytokine-dependent hematopoietic cell linker
Chromosome4
Location4p16.1 (10488019 ~ 10686489) to Ensembl
Sequene Features : Isoforms 3, Variants 67, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.intracellular signal transduction
.positive regulation of signal transduction
.transmembrane receptor protein tyrosine kinase signaling pathway
.immune response
.SH3/SH2 adaptor activity .intracellular
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 67 2
2014-09-19protein level
3 53 2
2014-05-27protein level
3 53 2
2014-02-25protein level
3 53 2
2013-12-09protein level
3 36 2
2013-11-01protein level
3 36 2
2013-09-12transcript level
3 36 2
2013-08-17transcript level
3 36 2
2013-07-15transcript level
3 26 2
2013-06-11transcript level
3 26 2
2013-02-12transcript level
3 9 6
2012-12-20transcript level
3 6 6
2012-10-30transcript level
3 14 6
2012-10-07transcript level
3 14 2
2012-08-24transcript level
3 12 2
2012-07-28transcript level
3 12 2
2012-06-08transcript level
3 14 2
2012-05-07transcript level
3 14 2
2012-04-10transcript level
3 14 2
2012-01-13transcript level
3 6 2
2011-12-20transcript level
3 6 2
2011-11-11transcript level
3 6 2
2011-08-23transcript level
3 6 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q7Z7G1-1
0 26 0 49523.0338
NX_Q7Z7G1-2
0 12 0 19403.9693
NX_Q7Z7G1-3
1 24 0 45440.7052
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-7878194,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
2 EBI-7878194,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood24
brain1
kidney9
muscle9
spleen37
Health State
TissuesTPM*
normal1
kidney tumor29
leukemia31
Developmental Stage
TissuesTPM*
adult4
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix1.2
kidney4.3
lymph node3
spleen1.6
Tissues
TissuesExpression level
adrenal glandLow
appendixLow
bone marrowMedium
cerebellumLow
cerebral cortexLow
cervix, uterineLow
colonLow
duodenumLow
endometrium 1Low
endometrium 2Low
epididymisLow
fallopian tubeLow
gallbladderLow
heart muscleMedium
kidneyLow
lungLow
lymph nodeHigh
nasopharynxLow
pancreasMedium
prostateLow
rectumLow
seminal vesicleLow
skeletal muscleLow
skin 1Medium
small intestineLow
soft tissue 1Low
soft tissue 2Low
stomach 1Low
stomach 2Low
testisLow
thyroid glandLow
tonsilHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*611434, gene) Cytokine-dependent hematopoietic cell linker; CLNKOMIM


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