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> Protein (NX_Q7Z7H8)
Protein (NX_Q7Z7H8)
Protein
Gene SymbolMRPL10 to neXtProt (NX_Q7Z7H8)
Description39S ribosomal protein L10, mitochondrial
Chromosome17
Location17q21.32 (45900638 ~ 45908900) to Ensembl
Sequene Features : Isoforms 2, Variants 38, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 4 more...
.poly(A) RNA binding
.structural constituent of ribosome
.ribonucleoprotein complex
.mitochondrial large ribosomal subunit
.mitochondrial inner membrane
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 38 0
2014-09-19protein level
2 33 0
2014-05-27protein level
2 33 0
2014-02-25protein level
2 33 0
2013-12-09protein level
2 24 0
2013-11-01protein level
2 22 0
2013-09-12protein level
2 22 0
2013-08-17protein level
2 22 0
2013-07-15protein level
2 16 0
2013-06-11protein level
2 16 0
2013-02-12protein level
2 7 0
2012-12-20protein level
2 7 0
2012-10-30protein level
1 5 0
2012-10-07protein level
1 5 0
2012-08-24protein level
1 4 0
2012-07-28protein level
1 4 0
2012-06-08protein level
1 4 0
2012-05-07protein level
1 4 0
2012-04-10protein level
1 4 0
2012-01-13protein level
1 1 0
2011-12-20protein level
1 1 0
2011-11-11protein level
1 1 0
2011-08-23protein level
1 1 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q7Z7H8-1
2 10 0 29263.5964
NX_Q7Z7H8-2
1 10 0 30287.9672
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-723524,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
2 EBI-723524,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
3 EBI-723524,EBI-740929 KLHL12  
  .negative regulation of canonical Wnt signaling pathway
.COPII vesicle coating
.Wnt signaling pathway
  + 2 more...
.N/A .Cul3-RING ubiquitin ligase complex
.ER to Golgi transport vesicle
.cytosol
.Golgi membrane
4 EBI-723524,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
5 EBI-723524,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
ascites75
bladder33
blood163
bone153
brain48
cervix247
connective tissue26
embryonic tissue51
eye81
heart55
intestine94
kidney61
liver53
lung125
lymph135
lymph node66
mammary gland52
mouth15
muscle37
ovary88
pancreas89
parathyroid48
pharynx24
pituitary gland121
placenta120
prostate52
salivary gland98
skin104
spleen18
stomach62
testis27
thymus37
trachea19
umbilical cord290
uterus34
vascular38
Health State
TissuesTPM*
normal54
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor42
cervical tumor289
chondrosarcoma120
colorectal tumor115
gastrointestinal tumor67
germ cell tumor75
glioma37
head and neck tumor14
kidney tumor116
leukemia137
liver tumor52
lung tumor184
lymphoma138
non-neoplasia72
ovarian tumor52
pancreatic tumor180
primitive neuroectodermal tumor of the CNS149
prostate cancer48
retinoblastoma86
skin tumor159
soft tissue/muscle tissue tumor47
uterine tumor44
Developmental Stage
TissuesTPM*
adult65
embryoid body14
blastocyst81
neonate128
fetus55
infant85
juvenile161
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue26.4
adrenal gland20.8
appendix18.5
bone marrow19.4
cerebral cortex19.1
colon23
duodenum22.6
esophagus25.8
gallbladder24.2
heart muscle42.7
kidney26.3
liver12.3
lung19.9
lymph node29.5
ovary50.9
pancreas13.3
placenta23.6
prostate21.1
salivary gland16.6
skin13.1
small intestine19.4
spleen23.6
stomach20.1
testis17.6
thyroid gland26.7
urinary bladder32
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowLow
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleHigh
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverHigh
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaMedium
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Low
soft tissue 2Medium
spleenHigh
stomach 1Medium
stomach 2High
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*611825, gene) Mitochondrial ribosomal protein l10; MRPL10OMIM


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