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> Protein (NX_Q86SE9)
Protein (NX_Q86SE9)
Protein
Gene SymbolPCGF5 to neXtProt (NX_Q86SE9)
DescriptionPolycomb group RING finger protein 5
Chromosome10
Location10q23.32 (92979908 ~ 93044088) to Ensembl
Sequene Features : Isoforms 2, Variants 26, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.zinc ion binding .PcG protein complex
.centrosome
.nucleolus
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 26 0
2014-09-19protein level
2 20 0
2014-05-27protein level
2 19 0
2014-02-25protein level
2 19 0
2013-12-09protein level
2 18 0
2013-11-01protein level
2 17 0
2013-09-12protein level
2 17 0
2013-08-17protein level
2 17 0
2013-07-15protein level
2 8 0
2013-06-11protein level
2 8 0
2013-02-12protein level
2 0 0
2012-12-20protein level
2 0 0
2012-10-30protein level
2 0 0
2012-10-07protein level
2 0 0
2012-08-24protein level
2 0 0
2012-07-28protein level
2 0 0
2012-06-08protein level
2 0 0
2012-05-07protein level
2 1 0
2012-04-10protein level
2 1 0
2012-01-13protein level
2 0 0
2011-12-20protein level
2 0 0
2011-11-11protein level
2 0 0
2011-08-23protein level
2 0 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q86SE9-1
11 1 0 29694.4135
NX_Q86SE9-2
1 1 0 5774.7411
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2827999,EBI-752313 RING1  
  .camera-type eye morphogenesis
.negative regulation of transcription, DNA-templated
.cellular protein metabolic process
  + 5 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.chromatin binding
.PRC1 complex
.PcG protein complex
.nuclear speck
  + 4 more...
2 EBI-2827999,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
3 EBI-2827999,EBI-10208579 BCOR  
  .negative regulation of tooth mineralization
.specification of axis polarity
.palate development
  + 9 more...
.transcription regulatory region DNA binding
.histone deacetylase binding
.heat shock protein binding
  + 2 more...
.nucleus
4 EBI-2827999,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
5 EBI-2827999,EBI-912440 PRMT6  
  .negative regulation of transcription, DNA-templated
.histone H4-R3 methylation
.histone H3-R2 methylation
  + 6 more...
.histone methyltransferase activity (H2A-R3 specific)
.histone methyltransferase activity (H3-R2 specific)
.histone methyltransferase activity (H4-R3 specific)
  + 5 more...
.cytosol
.nucleoplasm
.nucleus
6 EBI-2827999,EBI-722416 RNF2  
  .cellular protein metabolic process
.post-translational protein modification
.negative regulation of sequence-specific DNA binding transcription factor activity
  + 8 more...
.RING-like zinc finger domain binding
.ligase activity
.zinc ion binding
  + 2 more...
.MLL1 complex
.PRC1 complex
.PcG protein complex
  + 6 more...
7 EBI-2827999,EBI-712912 CBX8  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 3 more...
.methylated histone binding
.ubiquitin-protein transferase activity
.single-stranded RNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites25
blood89
bone55
bone marrow61
brain43
cervix20
connective tissue26
ear124
embryonic tissue9
eye43
heart11
intestine43
kidney61
liver29
lung47
lymph node155
mammary gland39
mouth15
muscle47
ovary39
pancreas51
parathyroid97
pituitary gland60
placenta24
prostate5
skin28
stomach83
testis78
thymus25
thyroid42
trachea135
uterus51
vascular58
Health State
TissuesTPM*
normal48
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma24
colorectal tumor35
gastrointestinal tumor75
germ cell tumor37
glioma27
head and neck tumor22
kidney tumor29
leukemia84
liver tumor41
lung tumor9
lymphoma27
non-neoplasia41
ovarian tumor65
pancreatic tumor85
primitive neuroectodermal tumor of the CNS7
skin tumor39
soft tissue/muscle tissue tumor15
uterine tumor88
Developmental Stage
TissuesTPM*
adult49
blastocyst16
neonate32
fetus48
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue19.9
adrenal gland31.6
appendix24.7
bone marrow57.1
cerebral cortex24.1
colon36.8
duodenum35.2
esophagus23.4
gallbladder23.2
heart muscle45.7
kidney30.2
liver23.8
lung23.7
lymph node29
ovary17.3
pancreas13.1
placenta18.9
prostate17
salivary gland22.1
skin13.5
small intestine34.6
spleen25.3
stomach25.4
testis34.3
thyroid gland31.6
urinary bladder24.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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