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> Protein (NX_Q86TM6)
Protein (NX_Q86TM6)
Protein
Gene SymbolSYVN1 to neXtProt (NX_Q86TM6)
DescriptionE3 ubiquitin-protein ligase synoviolin
Chromosome11
Location11q13.1 (64889252 ~ 64902004) to Ensembl
Sequene Features : Isoforms 3, Variants 67, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.cellular protein metabolic process
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 6 more...
.ubiquitin protein ligase activity
.acid-amino acid ligase activity
.zinc ion binding
.integral component of membrane
.membrane
.endoplasmic reticulum membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 67 1
2014-09-19protein level
3 49 1
2014-05-27protein level
3 49 1
2014-02-25protein level
3 47 1
2013-12-09protein level
3 41 1
2013-11-01protein level
3 40 1
2013-09-12protein level
3 40 1
2013-08-17protein level
3 40 1
2013-07-15protein level
3 29 1
2013-06-11protein level
3 29 1
2013-02-12protein level
3 11 3
2012-12-20protein level
3 10 3
2012-10-30protein level
3 12 3
2012-10-07protein level
3 12 1
2012-08-24protein level
3 7 1
2012-07-28protein level
3 7 1
2012-06-08protein level
3 10 1
2012-05-07protein level
3 10 1
2012-04-10protein level
3 10 1
2012-01-13protein level
3 4 1
2011-12-20protein level
3 4 1
2011-11-11protein level
3 4 1
2011-08-23protein level
3 4 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q86TM6-1
1 20 0 67640.1289
NX_Q86TM6-2
1 18 0 61691.0578
NX_Q86TM6-3
0 21 0 67569.092
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-947849,EBI-371750 ERN1  
  .peptidyl-serine trans-autophosphorylation
.insulin metabolic process
.positive regulation of endoplasmic reticulum unfolded protein response
  + 23 more...
.Hsp90 protein binding
.ADP binding
.protein homodimerization activity
  + 7 more...
.IRE1-RACK1-PP2A complex
.IRE1-TRAF2-ASK1 complex
.Ire1 complex
  + 6 more...
2 EBI-947849,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites25
blood57
bone83
brain26
cervix41
connective tissue26
ear62
embryonic tissue37
eye76
heart22
intestine94
kidney52
larynx127
liver38
lung59
lymph90
lymph node256
mammary gland185
mouth45
muscle9
nerve128
ovary88
pancreas74
pituitary gland121
placenta49
prostate47
skin237
spleen131
stomach31
testis248
thymus12
thyroid64
tonsil176
umbilical cord145
uterus43
vascular38
Health State
TissuesTPM*
normal56
adrenal tumor79
breast (mammary gland) tumor279
cervical tumor57
chondrosarcoma181
colorectal tumor106
gastrointestinal tumor50
germ cell tumor49
glioma27
head and neck tumor52
kidney tumor72
leukemia148
liver tumor41
lung tumor48
lymphoma124
non-neoplasia41
ovarian tumor105
pancreatic tumor76
primitive neuroectodermal tumor of the CNS7
prostate cancer57
retinoblastoma43
skin tumor358
soft tissue/muscle tissue tumor15
uterine tumor77
Developmental Stage
TissuesTPM*
adult74
embryoid body57
blastocyst48
neonate64
fetus100
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue26
adrenal gland30.7
appendix50.7
bone marrow34.2
cerebral cortex17.1
colon27.3
duodenum29
esophagus19.9
gallbladder26.1
heart muscle16.7
kidney16.9
liver33.1
lung27.5
lymph node80.3
ovary31.8
pancreas32
placenta32.2
prostate26.7
salivary gland49
skin19.4
small intestine25.6
spleen48.6
stomach33.6
testis26.2
thyroid gland55.5
urinary bladder34.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
colonHigh
duodenumMedium
endometrium 1Low
endometrium 2Low
epididymisMedium
fallopian tubeHigh
gallbladderHigh
heart muscleLow
hippocampusHigh
kidneyMedium
lateral ventricleMedium
liverMedium
lungHigh
lymph nodeHigh
nasopharynxLow
ovaryLow
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleLow
skeletal muscleLow
skin 1Medium
small intestineMedium
smooth muscleLow
soft tissue 1Low
soft tissue 2Medium
spleenLow
stomach 1Low
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608046, gene) Synovial apoptosis inhibitor 1; SYVN1OMIM


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